egg (Drosophila melanogaster)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01429 (MBD) IPR001739 FBgn0086908 T260522_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables histone methyltransferase activity (H3-K9 specific). Involved in female germ-line stem cell asymmetric division; histone H3-K9 methylation; and regulation of gene expression. Located in cytoplasm; nucleus; and polytene chromosome. Colocalizes with chromocenter. Is expressed in several structures, including dorsal ectoderm anlage; extended germ band embryo; germ layer; ovary; and stage 5 embryo. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to several human genes including SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
egg
M03917_2.00		 Drosophila melanogaster
HWWHAAGGTGATAHWH
DWDTATCACCTTDWWD		 SELEX
Nitta et al.(2015)
egg_1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0111689 MBD 819 887

Links

Other MBD family TFs
Other Drosophila melanogaster TFs

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10 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action