| NCBI Gene Info:Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including anal depressor muscle; body wall musculature; coelomocyte; intestine; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022] |