Tbx3 (Rattus norvegicus)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSRNOG00000008706 T340428_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbx3
M00834_2.00 		Mus musculus
NHNDCACNHN
NDNGTGHNDN		 PBM
Weirauch et al.(2013)
pTH3998 		0.920 1.000
TBX3
M05801_2.00 		Homo sapiens
NDSGTGTBRN
NYVACACSHN		 SELEX
Yin et al.(2017)
TBX3_eDBD_HT-SELEX 		0.920 1.000
TBX3
M09426_2.00 		Homo sapiens
DVDGGTGBNAR
YTNVCACCHBH		 Misc
Kulakovskiy et al.(2013)
TBX3_HUMAN.H11MO.0.C 		0.920 1.000
Tbx3
M09429_2.00 		Mus musculus
RRGGTGBBR
YVVCACCYY		 Misc
Kulakovskiy et al.(2013)
TBX3_MOUSE.H11MO.0.B 		0.920 1.000
TBX3
M05802_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX3_eDBD_Methyl-HT-SELEX 		0.920 1.000
Tbx2
M00830_2.00 		Mus musculus
NYVDCACBHN
NDVGTGHBRN		 PBM
Weirauch et al.(2013)
pTH3751 		0.906 0.950
TBX2
M03556_2.00 		Homo sapiens
GGTGTKADDWNTVACACB
VGTGTBANWHHTMACACC		 SELEX
Jolma et al.(2013)
TBX2_1 		0.906 0.950
TBX2
M03557_2.00 		Homo sapiens
NAGGTGTBAWN
NWTVACACCTN		 SELEX
Jolma et al.(2013)
TBX2_2 		0.906 0.950
TBX2
M05799_2.00 		Homo sapiens
NNVRCRCNNN
NNNGYGYBNN		 SELEX
Yin et al.(2017)
TBX2_eDBD_HT-SELEX 		0.906 0.950
Tbx2
M08044_2.00 		Mus musculus
GCHYBCTGGGADHTGTAGTYH
DRACTACADHTCCCAGVRDGC		 ChIP-seq
Chen et al.(2011)
SRP001585_Tbx2 		0.906 0.950
TBX2
M11381_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX2_Q2 		0.906 0.950
TBX2
M11382_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX2_Q5 		0.906 0.950
TBX2
M05800_2.00 		Homo sapiens
NNVRCRCBNN
NNVGYGYBNN		 SELEX
Yin et al.(2017)
TBX2_eDBD_Methyl-HT-SELEX 		0.906 0.950
TBX2
M02495_2.00 		Gasterosteus aculeatus
NNVDCACNHN
NDNGTGHBNN		 PBM
Weirauch et al.(2014)
pTH9182 		0.875 0.939
TBX2
M02496_2.00 		Takifugu rubripes
DAGGTGTBRN
NYVACACCTH		 PBM
Weirauch et al.(2014)
pTH9289 		0.875 0.934
XP_008203914.1
M01029_2.00 		Nasonia vitripennis
AGGTGTBA
TVACACCT		 PBM
SebePedros et al.(2013)
pTH9336 		0.840 0.856
estExt_fgenesh2_pg.C_1570024
M01030_2.00 		Branchiostoma floridae
NHNDCACNHN
NDNGTGHNDN		 PBM
SebePedros et al.(2013)
pTH9244 		0.819 0.718
Tbx5
M00833_2.00 		Mus musculus
AGGTGTBA
TVACACCT		 PBM
Weirauch et al.(2013)
pTH3775 		0.797 0.641
TBX5
M03552_2.00 		Homo sapiens
AGGTGTBA
TVACACCT		 SELEX
Jolma et al.(2013)
TBX5_1 		0.797 0.641
TBX5
M03553_2.00 		Homo sapiens
AGGTGTKANWWNTVACACCT
AGGTGTBANWWNTMACACCT		 SELEX
Jolma et al.(2013)
TBX5_2 		0.797 0.641
Tbx5
M09649_2.00 		Mus musculus
AGGTGHBA
TVDCACCT		 Misc
Heinz et al.(2010)
HL1-Tbx5.biotin_GSE21529 		0.797 0.641
TBX5
M11374_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_01 		0.797 0.641
TBX5
M11375_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_02 		0.797 0.641
Tbx5
M11387_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_05 		0.797 0.641
TBX5
M11376_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_Q2 		0.797 0.641
TBX5
M11377_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_Q5 		0.797 0.641
XP_001195863
M02498_2.00 		Strongylocentrotus purpuratus
AGGTGTBA
TVACACCT		 PBM
Weirauch et al.(2014)
pTH9340 		0.794 0.707
Tbx4
M00831_2.00 		Mus musculus
AGGTGTBA
TVACACCT		 PBM
Weirauch et al.(2013)
pTH3973 		0.783 0.641
TBX4
M03558_2.00 		Homo sapiens
AGGTGTBA
TVACACCT		 SELEX
Jolma et al.(2013)
TBX4_1 		0.783 0.641
TBX4
M03559_2.00 		Homo sapiens
AGGTGTBANWWNTVACACBT
AVGTGTBANWWNTVACACCT		 SELEX
Jolma et al.(2013)
TBX4_2 		0.783 0.641
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000011552 T-box 105 305
ENSRNOP00000074567 T-box 105 285

Links

Other T-box family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

329 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action