CIS-BP Database: Catalog of Inferred Sequence Binding Preferences

TF Information

EGR4 *(Loxodonta africana)* C2H2 ZF
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00096 (zf-C2H2)	IPR007087	ENSLAFG00000008635	T097304_2.00	Ensembl (2018-Dec-8)	Link out
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
EGR4 M02889_2.00	Homo sapiens	NHMCGCCCACGCAHHN	NDDTGCGTGGGCGKDN	SELEX Jolma et al.(2013) EGR4_1	0.827	1.000
EGR4 M02890_2.00	Homo sapiens	NHMCGCCCACGCAHWH	DWDTGCGTGGGCGKDN	SELEX Jolma et al.(2013) EGR4_2	0.827	1.000
EGR4 M04461_2.00	Homo sapiens	HMCGCCCACGCAH	DTGCGTGGGCGKD	SELEX Yin et al.(2017) EGR4_eDBD_HT-SELEX	0.827	1.000
EGR4 M10216_2.00	Homo sapiens	MCRCCCACGCAW	WTGCGTGGGYGK	Transfac Matys et al.(2006) V$NGFIC_01	0.827	1.000
EGR4 M04462_2.00	Homo sapiens	HMCGCCCMCGCRH	DYGCGKGGGCGKD	SELEX Yin et al.(2017) EGR4_eDBD_Methyl-HT-SELEX	0.827	1.000
Egr1 M01864_2.00	Mus musculus	CCCMCGYNN	NNRCGKGGG	PBM Weirauch et al.(2014) pTH5337	0.804	0.812
Egr1 M00375_2.00	Mus musculus	NCCYMCDNN	NNHGKRGGN	PBM Berger et al.(2006) Zif268	0.804	0.812
EGR1 M02883_2.00	Homo sapiens	NMCGCCCMCGCANN	NNTGCGKGGGCGKN	SELEX Jolma et al.(2013) EGR1_1	0.804	0.812
EGR1 M02884_2.00	Homo sapiens	HMCGCCCACGCAHW	WDTGCGTGGGCGKD	SELEX Jolma et al.(2013) EGR1_2	0.804	0.812
Egr1 M02932_2.00	Mus musculus	HHMCGCCCMCBCAHHH	DDDTGVGKGGGCGKDD	SELEX Jolma et al.(2013) Egr1_1	0.804	0.812
EGR1 M04437_2.00	Homo sapiens	NNCRCCCMCRCNN	NNGYGKGGGYGNN	SELEX Yin et al.(2017) EGR1_eDBD_HT-SELEX	0.804	0.812
Egr1 M05860_2.00	Mus musculus	NNMCRCCCMCGCN	NGCGKGGGYGKNN	SMiLE-seq Isakova et al.(2017) EGR1	0.804	0.812
EGR1 M07927_2.00	Homo sapiens	NVBNNNNBCCGCCCMCGCNB	VNGCGKGGGCGGVNNNNVBN	ChIP-seq Gerstein et al.(2012) GM12878_EGR1_HudsonAlpha	0.804	0.812
EGR1 M07928_2.00	Homo sapiens	BNCCGCCCMCGCNBB	VVNGCGKGGGCGGNV	ChIP-seq Gerstein et al.(2012) H1-hESC_EGR1_HudsonAlpha	0.804	0.812
EGR1 M07929_2.00	Homo sapiens	NNNNNNBNNCCRCCCMCGCN	NGCGKGGGYGGNNVNNNNNN	ChIP-seq Gerstein et al.(2012) K562_EGR1_HudsonAlpha	0.804	0.812
EGR1 M08882_2.00	Homo sapiens	BHNCCDCCCMCDCHBNB	VNVDGHGKGGGHGGNDV	Misc Kulakovskiy et al.(2013) EGR1_HUMAN.H11MO.0.A	0.804	0.812
Egr1 M08996_2.00	Mus musculus	YYCCRCCCMCGCNB	VNGCGKGGGYGGRR	Misc Kulakovskiy et al.(2013) EGR1_MOUSE.H11MO.0.A	0.804	0.812
EGR1 M09506_2.00	Homo sapiens	CRCCCMCRCA	TGYGKGGGYG	Misc Heinz et al.(2010) K562-Egr1_GSE32465	0.804	0.812
EGR1 M10188_2.00	Homo sapiens	MCGCCYACGCAW	WTGCGTRGGCGK	Transfac Matys et al.(2006) V$EGR1_01	0.804	0.812
EGR1 M10189_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_02	0.804	0.812
EGR1 M10190_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_09	0.804	0.812
EGR1 M10191_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_11	0.804	0.812
EGR1 M10192_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_12	0.804	0.812
EGR1 M10193_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_13	0.804	0.812
EGR1 M10194_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_15	0.804	0.812
EGR1 M10195_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_Q3	0.804	0.812
EGR1 M10196_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR1_Q6	0.804	0.812
EGR1 M04438_2.00	Homo sapiens	NHCDCCCMCNYNN	NNRNGKGGGHGDN	SELEX Yin et al.(2017) EGR1_eDBD_Methyl-HT-SELEX	0.804	0.812
Egr3 M00776_2.00	Mus musculus	HHDCCCMCDN	NHGKGGGHDD	PBM Weirauch et al.(2013) pTH2820	0.796	0.783
EGR3 M02915_2.00	Homo sapiens	NHMCGCCCMCGCAHN	NDTGCGKGGGCGKDN	SELEX Jolma et al.(2013) EGR3_1	0.796	0.783
Egr3 M02931_2.00	Mus musculus	HMCGCCCACGCAHWN	NWDTGCGTGGGCGKD	SELEX Jolma et al.(2013) Egr3_1	0.796	0.783
EGR3 M04583_2.00	Homo sapiens	HMCGCCCACGCRH	DYGCGTGGGCGKD	SELEX Yin et al.(2017) EGR3_FL_HT-SELEX	0.796	0.783
EGR3 M08349_2.00	Homo sapiens	CDCCYCCDC	GHGGRGGHG	ChIP-seq Schmitges et al.(2016) Q06889_1-3.RCADE	0.796	0.783
EGR3 M10279_2.00	Homo sapiens	MCGCCYACGCWN	NWGCGTRGGCGK	Transfac Matys et al.(2006) V$EGR3_01	0.796	0.783
EGR3 M10280_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR3_Q3	0.796	0.783
EGR3 M10281_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR3_Q6	0.796	0.783
EGR3 M04584_2.00	Homo sapiens	NMCGCCCACGCRH	DYGCGTGGGCGKN	SELEX Yin et al.(2017) EGR3_FL_Methyl-HT-SELEX	0.796	0.783
sr M06072_2.00	Drosophila melanogaster	HVMCGCCCMCVYMH	DKRBGKGGGCGKBD	B1H Zhu et al.(2011) sr_SANGER_5_FBgn0003499	0.790	0.797
sr M06073_2.00	Drosophila melanogaster	NNMCRCCCMCVHNN	NNDBGKGGGYGKNN	B1H Zhu et al.(2011) sr_SOLEXA_5_FBgn0003499	0.790	0.797
EGR2 M00233_2.00	Homo sapiens	HDCCCMCDBN	NVHGKGGGHD	PBM Barrera et al.(2016) EGR2_REF	0.784	0.783
Egr2 M00778_2.00	Mus musculus	YRCCCMCGYN	NRCGKGGGYR	PBM Weirauch et al.(2013) pTH3091	0.784	0.783
EGR2 M02885_2.00	Homo sapiens	MCGCCCACGCD	HGCGTGGGCGK	SELEX Jolma et al.(2013) EGR2_1	0.784	0.783
EGR2 M02886_2.00	Homo sapiens	NNMCGCCCACGCDNN	NNHGCGTGGGCGKNN	SELEX Jolma et al.(2013) EGR2_2	0.784	0.783
EGR2 M04439_2.00	Homo sapiens	HMCRCCCACGCNN	NNGCGTGGGYGKD	SELEX Yin et al.(2017) EGR2_FL_HT-SELEX	0.784	0.783
EGR2 M08302_2.00	Homo sapiens	CDCCCMCDC	GHGKGGGHG	ChIP-seq Schmitges et al.(2016) P11161_1-3.RCADE	0.784	0.783
EGR2 M08884_2.00	Homo sapiens	YYCCDCCCMCDCHYHYHY	RDRDRDGHGKGGGHGGRR	Misc Kulakovskiy et al.(2013) EGR2_HUMAN.H11MO.0.A	0.784	0.783
Egr2 M08994_2.00	Mus musculus	BHYCCDCCCMCDCN	NGHGKGGGHGGRDV	Misc Kulakovskiy et al.(2013) EGR2_MOUSE.H11MO.0.A	0.784	0.783
Egr2 M09515_2.00	Mus musculus	NMCRCCCACDSN	NSHGTGGGYGKN	Misc Heinz et al.(2010) Thymocytes-Egr2_GSE34254	0.784	0.783
EGR2 M10197_2.00	Homo sapiens	MCGCCYACGCAH	DTGCGTRGGCGK	Transfac Matys et al.(2006) V$EGR2_01	0.784	0.783
EGR2 M10198_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR2_Q4	0.784	0.783
EGR2 M10199_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$EGR2_Q6	0.784	0.783
EGR2 M04440_2.00	Homo sapiens	NMCGCCCACRCRN	NYGYGTGGGCGKN	SELEX Yin et al.(2017) EGR2_FL_Methyl-HT-SELEX	0.784	0.783
EGR2 M00232_2.00	Homo sapiens	NHMCGCCYNN	NNRGGCGKDN	PBM Barrera et al.(2016) EGR2_R409W	0.782	0.768
egrh-1 M00622_2.00	Caenorhabditis elegans	CSCCCMCR	YGKGGGSG	PBM Narasimhan et al.(2015) pTH9317	0.774	0.783
For this family, TFs with SR scores > 0.755* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSLAFP00000007253	C2H2 ZF	373	397	FACPVESCVRSFARSDELNRHLRIH
ENSLAFP00000007253	C2H2 ZF	403	425	FQCRICLRNFSRSDHLTTHVRTH
ENSLAFP00000007253	C2H2 ZF	431	453	FACDVCGRRFARSDEKKRHSKVH

Links
Other C2H2 ZF family TFs
Other *Loxodonta africana* TFs

347 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action

EGR4 (Loxodonta africana) C2H2 ZF

TF Information

Directly determined binding motifs

Motifs from related TFs

DNA Binding Domains

Links

347 Related TFs

EGR4 **(Loxodonta africana)
C2H2 ZF**