Plag1 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000003282 T100979_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; positive regulation of gene expression; and positive regulation of glial cell proliferation. Acts upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PLAG1
M06465_2.00 		Homo sapiens
CCCCCKWDGGCCCC
GGGGCCHWMGGGGG		 B1H
Mathelier et al.(2014)
MA0163.1 		0.823 0.969
PLAG1
M10286_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PLAG1_01 		0.823 0.969
PLAG1
M10287_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PLAG1_02 		0.823 0.969
PLAG1
M10288_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PLAG1_08 		0.823 0.969
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000003369 C2H2 ZF 34 56
ENSMUSP00000003369 C2H2 ZF 62 86
ENSMUSP00000003369 C2H2 ZF 92 114
ENSMUSP00000003369 C2H2 ZF 121 143
ENSMUSP00000003369 C2H2 ZF 150 172
ENSMUSP00000003369 C2H2 ZF 185 207
ENSMUSP00000003369 C2H2 ZF 213 236

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

54 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action