| NCBI Gene Info:Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Involved in several processes, including defense response to other organism; positive regulation of cellular biosynthetic process; and positive regulation of defense response to virus by host. Located in cytoplasm and nucleus. Is expressed in adult Malpighian tubule and organism. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bloch-Sulzberger syndrome; Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma) and OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022] |