CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ISL2
(
Homo sapiens
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSG00000159556
T209868_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and neuron differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ISL2
M03177_2.00
Homo sapiens
YTAAKTGB
VCAMTTAR
SELEX
Jolma et al.(2013)
ISL2_1
(Direct)
(Direct)
ISL2
M05204_2.00
Homo sapiens
NTAAKTGS
SCAMTTAN
SELEX
Yin et al.(2017)
ISL2_eDBD_HT-SELEX
(Direct)
(Direct)
ISL2
M05205_2.00
Homo sapiens
NTAAKTGN
NCAMTTAN
SELEX
Yin et al.(2017)
ISL2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Isl2
M00458_2.00
Mus musculus
NWDWDNN
NNHWHWN
PBM
Berger et al.(2008)
Isl2_3430
0.867
1.000
ISL1
M04908_2.00
Homo sapiens
BTAAKTGS
SCAMTTAV
SELEX
Yin et al.(2017)
ISL1_eDBD_HT-SELEX
0.867
1.000
ISL1
M04910_2.00
Homo sapiens
NTAAKTGS
SCAMTTAN
SELEX
Yin et al.(2017)
ISL1_FL_HT-SELEX
0.867
1.000
ISL1
M09128_2.00
Homo sapiens
NYWRAKKGV
BCMMTYWRN
Misc
Kulakovskiy et al.(2013)
ISL1_HUMAN.H11MO.0.A
0.867
1.000
Isl1
M09209_2.00
Mus musculus
NYWRAKKGV
BCMMTYWRN
Misc
Kulakovskiy et al.(2013)
ISL1_MOUSE.H11MO.0.A
0.867
1.000
Isl1
M09578_2.00
Mus musculus
YTAAKKGV
BCMMTTAR
Misc
Heinz et al.(2010)
Neuron-Isl1_GSE31456
0.867
1.000
ISL1
M10634_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ISL1_Q3
0.867
1.000
ISL1
M10635_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ISL1_Q6
0.867
1.000
ISL1
M04909_2.00
Homo sapiens
BTAAKTGS
SCAMTTAV
SELEX
Yin et al.(2017)
ISL1_eDBD_Methyl-HT-SELEX
0.867
1.000
ISL1
M04911_2.00
Homo sapiens
BTAAKTGS
SCAMTTAV
SELEX
Yin et al.(2017)
ISL1_FL_Methyl-HT-SELEX
0.867
1.000
ISL2B_ONCTS
M10798_2.00
Oncorhynchus tshawytscha
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ISL2_02
0.866
0.982
ISL2B_ONCTS
M10799_2.00
Oncorhynchus tshawytscha
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ISL2_03
0.866
0.982
ISL2B_ONCTS
M10800_2.00
Oncorhynchus tshawytscha
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ISL2_04
0.866
0.982
ISL2B_ONCTS
M10801_2.00
Oncorhynchus tshawytscha
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ISL2_05
0.866
0.982
tup
M06498_2.00
Drosophila melanogaster
WTAATKG
CMATTAW
B1H
Mathelier et al.(2014)
MA0248.1
0.864
0.965
tup
M06270_2.00
Drosophila melanogaster
SWTAATKG
CMATTAWS
B1H
Zhu et al.(2011)
Tup_Cell_FBgn0003896
0.864
0.965
tup
M06271_2.00
Drosophila melanogaster
NYTAATKRV
BYMATTARN
B1H
Zhu et al.(2011)
tup_SOLEXA_10_FBgn0003896
0.864
0.965
tup
M06272_2.00
Drosophila melanogaster
YTAATKR
YMATTAR
B1H
Zhu et al.(2011)
Tup_SOLEXA_FBgn0003896
0.864
0.965
CBG04010
M01242_2.00
Caenorhabditis briggsae
NNKTAATDDMN
NKHHATTAMNN
PBM
Lambert et al.(2019)
pTH11489
0.835
0.772
NEMVEDRAFT_v1g81309
M02152_2.00
Nematostella vectensis
NTAATDNNN
NNNHATTAN
PBM
Weirauch et al.(2014)
pTH5477
0.636
0.351
NOTO
M03241_2.00
Homo sapiens
NNTAATKWRN
NYWMATTANN
SELEX
Jolma et al.(2013)
NOTO_1
0.631
0.368
NOTO
M05390_2.00
Homo sapiens
BTAATKRV
BYMATTAV
SELEX
Yin et al.(2017)
NOTO_eDBD_HT-SELEX
0.631
0.368
NOTO
M05391_2.00
Homo sapiens
BTMATKRV
BYMATKAV
SELEX
Yin et al.(2017)
NOTO_eDBD_Methyl-HT-SELEX
0.631
0.368
PHOX2B
M00278_2.00
Homo sapiens
NNNNNRY
RYNNNNN
PBM
Barrera et al.(2016)
PHOX2B_Q143R
0.623
0.368
Noto
M02101_2.00
Mus musculus
NNHHATDDNN
NNHHATDDNN
PBM
Weirauch et al.(2014)
pTH6268
0.613
0.351
VSX1
M00269_2.00
Homo sapiens
NNWAAYNNN
NNNRTTWNN
PBM
Barrera et al.(2016)
VSX1_REF
0.608
0.386
Vsx1
M00459_2.00
Mus musculus
NNTAATDDN
NHHATTANN
PBM
Berger et al.(2008)
Vsx1_1728
0.608
0.386
Vsx1
M03267_2.00
Mus musculus
NTAATTRN
NYAATTAN
SELEX
Jolma et al.(2013)
Vsx1_1
0.608
0.386
VSX1
M00266_2.00
Homo sapiens
NNTAAYNNN
NNNRTTANN
PBM
Barrera et al.(2016)
VSX1_G160D
0.608
0.386
Sebox
M02097_2.00
Mus musculus
NHTTAATTAN
NTAATTAADN
PBM
Weirauch et al.(2014)
pTH6379
0.605
0.421
ceh-5
M02179_2.00
Caenorhabditis elegans
NNTAATDDN
NHHATTANN
PBM
Weirauch et al.(2014)
pTH6562
0.604
0.368
SHOX
M02095_2.00
Homo sapiens
NTAATTRN
NYAATTAN
PBM
Weirauch et al.(2014)
pTH5805
0.601
0.404
Shox2
M00439_2.00
Mus musculus
NTAATDDN
NHHATTAN
PBM
Berger et al.(2008)
Shox2_2641
0.601
0.404
SHOX
M03232_2.00
Homo sapiens
NTAATTRN
NYAATTAN
SELEX
Jolma et al.(2013)
SHOX_1
0.601
0.404
SHOX2
M03204_2.00
Homo sapiens
BTAATTRN
NYAATTAV
SELEX
Jolma et al.(2013)
SHOX2_1
0.601
0.404
Shox2
M03263_2.00
Mus musculus
NTAATTRN
NYAATTAN
SELEX
Jolma et al.(2013)
Shox2_1
0.601
0.404
CG5369
M03876_2.00
Drosophila melanogaster
TAATTHVATTA
TAATBDAATTA
SELEX
Nitta et al.(2015)
CG5369_1
0.601
0.404
CG5369
M03877_2.00
Drosophila melanogaster
TAATTRNNTAATBN
NVATTANNYAATTA
SELEX
Nitta et al.(2015)
CG5369_2
0.601
0.404
CG5369
M03878_2.00
Drosophila melanogaster
TAATTVRATWA
TWATYBAATTA
SELEX
Nitta et al.(2015)
CG5369_3
0.601
0.404
SHOX
M05366_2.00
Homo sapiens
NTAATTRV
BYAATTAN
SELEX
Yin et al.(2017)
SHOX_eDBD_HT-SELEX
0.601
0.404
Shox2
M10772_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SHOX2_05
0.601
0.404
SHOX
M05367_2.00
Homo sapiens
NTAATTRV
BYAATTAN
SELEX
Yin et al.(2017)
SHOX_eDBD_Methyl-HT-SELEX_1
0.601
0.404
SHOX
M05368_2.00
Homo sapiens
NTAAYGAN
NTCRTTAN
SELEX
Yin et al.(2017)
SHOX_eDBD_Methyl-HT-SELEX_2
0.601
0.404
C4B866_NEMVE
M02052_2.00
Nematostella vectensis
NNTTAATTARNN
NNYTAATTAANN
PBM
Weirauch et al.(2014)
pTH6176
0.600
0.421
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000290759
Homeodomain
192
248
TRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK
Links
Other
Homeodomain
family TFs
Other
Homo sapiens
TFs
604 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy