DUX4 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000260596 T209956_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
DUX4
M08135_2.00		 Homo sapiens
TAAYYYAATCA
TGATTRRRTTA		 ChIP-seq
Mathelier et al.(2014)
MA0468.1		 (Direct) (Direct)
DUX4
M09167_2.00		 Homo sapiens
TAAYYYAATCA
TGATTRRRTTA		 Misc
Kulakovskiy et al.(2013)
DUX4_HUMAN.H11MO.0.A		 (Direct) (Direct)
DUX4
M10757_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$DUX4_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
DUX3_HUMAN
M10633_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$DUX3_01 		0.751 0.866
DUX1_HUMAN
M10631_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$DUX1_01 		0.749 0.884
DUX1_HUMAN
M10632_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$DUX1_02 		0.749 0.884
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000455112 Homeodomain 20 76
ENSP00000455112 Homeodomain 95 149
ENSP00000456539 Homeodomain 20 76
ENSP00000456539 Homeodomain 95 149
ENSP00000458065 Homeodomain 20 76
ENSP00000458065 Homeodomain 95 149
ENSP00000483555 Homeodomain 20 76
ENSP00000483555 Homeodomain 95 149

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

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31 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action