CIS-BP Database: Catalog of Inferred Sequence Binding Preferences

TF Information

ENSXMAG00000003977 *(Xiphophorus maculatus)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00046 (Homeobox)	IPR001356	ENSXMAG00000003977	T217159_2.00	Ensembl (2018-Dec-8)	Link out
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Dmbx1 M00441_2.00	Mus musculus	NTAATCYNN	NNRGATTAN	PBM Berger et al.(2008) Dmbx1_2277	0.867	1.000
DMBX1 M03236_2.00	Homo sapiens	NHTAATCCBN	NVGGATTADN	SELEX Jolma et al.(2013) DMBX1_1	0.867	1.000
DMBX1 M05383_2.00	Homo sapiens	NTAATCSN	NSGATTAN	SELEX Yin et al.(2017) DMBX1_eDBD_HT-SELEX	0.867	1.000
DMBX1 M05384_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Yin et al.(2017) DMBX1_eDBD_Methyl-HT-SELEX	0.867	1.000
ceh-53 M00679_2.00	Caenorhabditis elegans	HTAATCYN	NRGATTAD	PBM Narasimhan et al.(2015) pTH10699	0.817	0.649
CRX M00274_2.00	Homo sapiens	NMTAATCCSN	NSGGATTAKN	PBM Barrera et al.(2016) CRX_REF	0.775	0.667
Crx M00489_2.00	Mus musculus	NWAAKMBN	NVKMTTWN	PBM Berger et al.(2008) Crx_3485	0.775	0.667
CRX M04949_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) CRX_FL_HT-SELEX	0.775	0.667
Crx M08139_2.00	Mus musculus	YTAATCCYCYY	RRGRGGATTAR	ChIP-seq Mathelier et al.(2014) MA0467.1	0.775	0.667
CRX M09132_2.00	Homo sapiens	BYTAATCCBHYYN	NRRDVGGATTARV	Misc Kulakovskiy et al.(2013) CRX_HUMAN.H11MO.0.B	0.775	0.667
Crx M09208_2.00	Mus musculus	BYTAATCCBHYYN	NRRDVGGATTARV	Misc Kulakovskiy et al.(2013) CRX_MOUSE.H11MO.0.A	0.775	0.667
Crx M09577_2.00	Mus musculus	NYTAATCC	GGATTARN	Misc Heinz et al.(2010) Retina-Crx_GSE20012	0.775	0.667
CRX M10647_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$CRX_Q4_01	0.775	0.667
CRX M10648_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$CRX_Q4_02	0.775	0.667
CRX M04950_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Yin et al.(2017) CRX_FL_Methyl-HT-SELEX	0.775	0.667
Gsc M02120_2.00	Drosophila melanogaster	NTAATCYN	NRGATTAN	PBM Weirauch et al.(2014) pTH5511	0.772	0.702
Gsc M03817_2.00	Drosophila melanogaster	TAATCCB	VGGATTA	SELEX Nitta et al.(2015) Gsc_1	0.772	0.702
Gsc M03818_2.00	Drosophila melanogaster	TAATCGGATTA	TAATCCGATTA	SELEX Nitta et al.(2015) Gsc_2	0.772	0.702
Gsc M03819_2.00	Drosophila melanogaster	TAATCYNHTAATCBN	NVGATTADNRGATTA	SELEX Nitta et al.(2015) Gsc_3	0.772	0.702
Gsc M03820_2.00	Drosophila melanogaster	TAATCGGATTA	TAATCCGATTA	SELEX Nitta et al.(2015) Gsc_4	0.772	0.702
Gsc M03821_2.00	Drosophila melanogaster	TAATCYNWTWATCYB	VRGATWAWNRGATTA	SELEX Nitta et al.(2015) Gsc_5	0.772	0.702
Gsc M05873_2.00	Drosophila melanogaster	TAATCSNHTWA	TWADNSGATTA	SMiLE-seq Isakova et al.(2017) Gsc	0.772	0.702
Gsc M06509_2.00	Drosophila melanogaster	TAATCY	RGATTA	B1H Mathelier et al.(2014) MA0190.1	0.772	0.702
Gsc M06297_2.00	Drosophila melanogaster	VNTAATCY	RGATTANB	B1H Zhu et al.(2011) Gsc_Cell_FBgn0010323	0.772	0.702
Gsc M06298_2.00	Drosophila melanogaster	NTAATCY	RGATTAN	B1H Zhu et al.(2011) Gsc_SOLEXA_FBgn0010323	0.772	0.702
ceh-37 M00674_2.00	Caenorhabditis elegans	HTAATCYN	NRGATTAD	PBM Narasimhan et al.(2015) pTH10716	0.769	0.596
CRX M00275_2.00	Homo sapiens	NMTAATCCSN	NSGGATTAKN	PBM Barrera et al.(2016) CRX_V66I	0.765	0.649
CRX M00273_2.00	Homo sapiens	NNYTAATCCVN	NBGGATTARNN	PBM Barrera et al.(2016) CRX_R90W	0.765	0.649
Otx1 M00396_2.00	Mus musculus	NTAAKCYN	NRGMTTAN	PBM Berger et al.(2008) Otx1_2325	0.764	0.649
Otx2 M00418_2.00	Mus musculus	NTAAKMBN	NVKMTTAN	PBM Berger et al.(2008) Otx2_3441	0.764	0.649
OTX1 M03116_2.00	Homo sapiens	NNTAAKCGGATTANN	NNTAATCCGMTTANN	SELEX Jolma et al.(2013) OTX1_1	0.764	0.649
OTX1 M03117_2.00	Homo sapiens	NTAATCSB	VSGATTAN	SELEX Jolma et al.(2013) OTX1_2	0.764	0.649
OTX2 M03197_2.00	Homo sapiens	NHTAAKCGGATTANN	NNTAATCCGMTTADN	SELEX Jolma et al.(2013) OTX2_1	0.764	0.649
OTX2 M03198_2.00	Homo sapiens	HTAATCCB	VGGATTAD	SELEX Jolma et al.(2013) OTX2_2	0.764	0.649
Otx1 M03249_2.00	Mus musculus	NNTAAKCGGATTANN	NNTAATCCGMTTANN	SELEX Jolma et al.(2013) Otx1_1	0.764	0.649
Otx1 M03250_2.00	Mus musculus	NTAATCCN	NGGATTAN	SELEX Jolma et al.(2013) Otx1_2	0.764	0.649
oc M03808_2.00	Drosophila melanogaster	HTAATCCB	VGGATTAD	SELEX Nitta et al.(2015) oc_1	0.764	0.649
OTX1 M05022_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) OTX1_eDBD_HT-SELEX	0.764	0.649
OTX1 M05024_2.00	Homo sapiens	NTAATCCNNN	NNNGGATTAN	SELEX Yin et al.(2017) OTX1_FL_HT-SELEX	0.764	0.649
OTX2 M05251_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) OTX2_FL_HT-SELEX	0.764	0.649
oc M06502_2.00	Drosophila melanogaster	TAATCC	GGATTA	B1H Mathelier et al.(2014) MA0234.1	0.764	0.649
oc M06282_2.00	Drosophila melanogaster	WTAATCC	GGATTAW	B1H Zhu et al.(2011) Oc_Cell_FBgn0004102	0.764	0.649
oc M06283_2.00	Drosophila melanogaster	NTAATCCB	VGGATTAN	B1H Zhu et al.(2011) Oc_SOLEXA_FBgn0004102	0.764	0.649
OTX2 M09153_2.00	Homo sapiens	BYTAATCCYYN	NRRGGATTARV	Misc Kulakovskiy et al.(2013) OTX2_HUMAN.H11MO.0.A	0.764	0.649
Otx2 M09183_2.00	Mus musculus	HTAATCCYNYNN	NNRNRGGATTAD	Misc Kulakovskiy et al.(2013) OTX2_MOUSE.H11MO.0.A	0.764	0.649
Otx2 M09569_2.00	Mus musculus	NHTAATCCHB	VDGGATTADN	Misc Heinz et al.(2010) EpiLC-Otx2_GSE56098	0.764	0.649
oc M09681_2.00	Drosophila melanogaster	HTAATCCN	NGGATTAD	Misc Kulakovskiy et al.(2009) oc	0.764	0.649
OTX1 M10673_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$OTX1_Q5	0.764	0.649
OTX2 M10727_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$OTX2_Q3_01	0.764	0.649
OTX2 M10728_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$OTX2_Q3	0.764	0.649
OTX1 M05023_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) OTX1_eDBD_Methyl-HT-SELEX	0.764	0.649
OTX1 M05025_2.00	Homo sapiens	HTAATCCNHN	NDNGGATTAD	SELEX Yin et al.(2017) OTX1_FL_Methyl-HT-SELEX	0.764	0.649
OTX2 M05252_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) OTX2_FL_Methyl-HT-SELEX	0.764	0.649
PITX2 M00311_2.00	Homo sapiens	TTAATCCY	RGGATTAA	PBM Barrera et al.(2016) PITX2_R108H	0.760	0.684
NEMVEDRAFT_v1g113057 M02144_2.00	Nematostella vectensis	NYTAATCCBN	NVGGATTARN	PBM Weirauch et al.(2014) pTH6135	0.755	0.579
PITX2 M00313_2.00	Homo sapiens	NWAAKHYN	NRDMTTWN	PBM Barrera et al.(2016) PITX2_REF	0.755	0.667
Pitx1 M00415_2.00	Mus musculus	NTAATCYNN	NNRGATTAN	PBM Berger et al.(2008) Pitx1_2312	0.755	0.667
Pitx3 M00428_2.00	Mus musculus	NTAAKCYN	NRGMTTAN	PBM Berger et al.(2008) Pitx3_3497	0.755	0.667
Pitx2 M00440_2.00	Mus musculus	NTAATCCN	NGGATTAN	PBM Berger et al.(2008) Pitx2_2274	0.755	0.667
PITX1 M03082_2.00	Homo sapiens	NHTAATCCN	NGGATTADN	SELEX Jolma et al.(2013) PITX1_1	0.755	0.667
PITX1 M03083_2.00	Homo sapiens	NHTAATCCN	NGGATTADN	SELEX Jolma et al.(2013) PITX1_2	0.755	0.667
PITX1 M03084_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Jolma et al.(2013) PITX1_3	0.755	0.667
PITX3 M03111_2.00	Homo sapiens	NHTAATCCN	NGGATTADN	SELEX Jolma et al.(2013) PITX3_1	0.755	0.667
PITX1 M04928_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) PITX1_eDBD_HT-SELEX	0.755	0.667
PITX1 M04930_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) PITX1_FL_HT-SELEX	0.755	0.667
PITX2 M05229_2.00	Homo sapiens	NTAAKCCN	NGGMTTAN	SELEX Yin et al.(2017) PITX2_eDBD_HT-SELEX	0.755	0.667
PITX2 M05231_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) PITX2_FL_HT-SELEX	0.755	0.667
PITX3 M04997_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) PITX3_eDBD_HT-SELEX	0.755	0.667
Pitx1 M09182_2.00	Mus musculus	NYWAAKCCYH	DRGGMTTWRN	Misc Kulakovskiy et al.(2013) PITX1_MOUSE.H11MO.0.C	0.755	0.667
PITX1 M10640_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX1_Q4	0.755	0.667
PITX1 M10641_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX1_Q6	0.755	0.667
PITX2 M10720_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX2_Q2	0.755	0.667
PITX2 M10721_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX2_Q4	0.755	0.667
PITX2 M10722_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX2_Q6	0.755	0.667
PITX3 M10660_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX3_Q2	0.755	0.667
PITX3 M10661_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX3_Q3_01	0.755	0.667
PITX3 M10662_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PITX3_Q3	0.755	0.667
PITX2 M00312_2.00	Homo sapiens	NNNTATWAATTNN	NNAATTWATANNN	PBM Barrera et al.(2016) PITX2_R130W	0.755	0.667
PITX2 M00314_2.00	Homo sapiens	NTAATMYN	NRKATTAN	PBM Barrera et al.(2016) PITX2_T114P	0.755	0.667
PITX1 M04929_2.00	Homo sapiens	NTAAKCCN	NGGMTTAN	SELEX Yin et al.(2017) PITX1_eDBD_Methyl-HT-SELEX	0.755	0.667
PITX1 M04931_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Yin et al.(2017) PITX1_FL_Methyl-HT-SELEX	0.755	0.667
PITX2 M05230_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Yin et al.(2017) PITX2_eDBD_Methyl-HT-SELEX	0.755	0.667
PITX2 M05232_2.00	Homo sapiens	YTAATCCY	RGGATTAR	SELEX Yin et al.(2017) PITX2_FL_Methyl-HT-SELEX	0.755	0.667
PITX3 M04998_2.00	Homo sapiens	NTAATCCN	NGGATTAN	SELEX Yin et al.(2017) PITX3_eDBD_Methyl-HT-SELEX	0.755	0.667
PITX2 M00310_2.00	Homo sapiens	HTAATCYN	NRGATTAD	PBM Barrera et al.(2016) PITX2_L100Q	0.755	0.649
Ptx1 M02123_2.00	Drosophila melanogaster	NTAATCYNN	NNRGATTAN	PBM Weirauch et al.(2014) pTH5644	0.755	0.667
Ptx1 M00562_2.00	Drosophila melanogaster	NYTAATCCBN	NVGGATTARN	PBM Busser et al.(2012a) Ptx1	0.755	0.667
Ptx1 M03842_2.00	Drosophila melanogaster	NTAATCCN	NGGATTAN	SELEX Nitta et al.(2015) Ptx1_1	0.755	0.667
Ptx1 M03843_2.00	Drosophila melanogaster	NTAATCCN	NGGATTAN	SELEX Nitta et al.(2015) Ptx1_2	0.755	0.667
Ptx1 M03844_2.00	Drosophila melanogaster	NCGHTAATCCN	NGGATTADCGN	SELEX Nitta et al.(2015) Ptx1_3	0.755	0.667
Ptx1 M06521_2.00	Drosophila melanogaster	YTAATCC	GGATTAR	B1H Mathelier et al.(2014) MA0201.1	0.755	0.667
Ptx1 M06319_2.00	Drosophila melanogaster	YTAATCC	GGATTAR	B1H Zhu et al.(2011) Ptx1_Cell_FBgn0020912	0.755	0.667
Ptx1 M06320_2.00	Drosophila melanogaster	NYTAATCC	GGATTARN	B1H Zhu et al.(2011) Ptx1_SOLEXA_FBgn0020912	0.755	0.667
CRX M00270_2.00	Homo sapiens	NWDAKNN	NNMTHWN	PBM Barrera et al.(2016) CRX_E80A	0.755	0.649
ceh-36 M00673_2.00	Caenorhabditis elegans	NWAATCYN	NRGATTWN	PBM Narasimhan et al.(2015) pTH10730	0.753	0.632
HBX4_ECHGR M02195_2.00	Echinococcus granulosus	NHTAATCYNN	NNRGATTADN	PBM Weirauch et al.(2014) pTH6301	0.753	0.561
CBG01820 M01241_2.00	Caenorhabditis briggsae	NTAATCCN	NGGATTAN	PBM Lambert et al.(2019) pTH11454	0.747	0.561
CRX M00271_2.00	Homo sapiens	NHDAKNN	NNMTHDN	PBM Barrera et al.(2016) CRX_R41Q	0.742	0.649
CRX M00272_2.00	Homo sapiens	NNHNATNN	NNATNDNN	PBM Barrera et al.(2016) CRX_R41W	0.742	0.649
Gsc M00411_2.00	Mus musculus	NNTAATYBN	NVRATTANN	PBM Berger et al.(2008) Gsc_2327	0.741	0.632
GSC M03146_2.00	Homo sapiens	NHTAATCCNH	DNGGATTADN	SELEX Jolma et al.(2013) GSC_1	0.741	0.632
GSC M05134_2.00	Homo sapiens	NTAATCCB	VGGATTAN	SELEX Yin et al.(2017) GSC_eDBD_HT-SELEX	0.741	0.632
GSC M05136_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Yin et al.(2017) GSC_FL_HT-SELEX	0.741	0.632
gsc M09584_2.00	Xenopus tropicalis	NTAATCYN	NRGATTAN	Misc Heinz et al.(2010) FrogEmbryos-GSC_DRA000576	0.741	0.632
GSC M05135_2.00	Homo sapiens	HTAATCCB	VGGATTAD	SELEX Yin et al.(2017) GSC_eDBD_Methyl-HT-SELEX	0.741	0.632
GSC M05137_2.00	Homo sapiens	HTAATCCN	NGGATTAD	SELEX Yin et al.(2017) GSC_FL_Methyl-HT-SELEX	0.741	0.632
GSC2 M03080_2.00	Homo sapiens	NHTAATCCBH	DVGGATTADN	SELEX Jolma et al.(2013) GSC2_1	0.739	0.596
GSC2 M04920_2.00	Homo sapiens	NTAATNNN	NNNATTAN	SELEX Yin et al.(2017) GSC2_eDBD_HT-SELEX	0.739	0.596
GSC2 M04921_2.00	Homo sapiens	NTAATCYN	NRGATTAN	SELEX Yin et al.(2017) GSC2_eDBD_Methyl-HT-SELEX	0.739	0.596
DPRX M03237_2.00	Homo sapiens	NHTAATCYNN	NNRGATTADN	SELEX Jolma et al.(2013) DPRX_1	0.691	0.404
DPRX M03238_2.00	Homo sapiens	NRGMTAATCYN	NRGATTAKCYN	SELEX Jolma et al.(2013) DPRX_2	0.691	0.404
DPRX M05388_2.00	Homo sapiens	VGMTAATCYN	NRGATTAKCB	SELEX Yin et al.(2017) DPRX_eDBD_HT-SELEX	0.691	0.404
DPRX M05389_2.00	Homo sapiens	AGATMATCYN	NRGATKATCT	SELEX Yin et al.(2017) DPRX_eDBD_Methyl-HT-SELEX	0.691	0.404
Obox6 M00490_2.00	Mus musculus	NTAATCYNN	NNRGATTAN	PBM Berger et al.(2008) Obox6_3440	0.620	0.386
AGAP006642 M02035_2.00	Anopheles gambiae	NHTAATCY	RGATTADN	PBM Weirauch et al.(2014) pTH6201	0.615	0.316
dve M02122_2.00	Drosophila melanogaster	NTAATCCV	BGGATTAN	PBM Weirauch et al.(2014) pTH6218	0.615	0.316
dharma M02080_2.00	Danio rerio	NNRAKCY	RGMTYNN	PBM Weirauch et al.(2014) pTH6530	0.613	0.509
For this family, TFs with SR scores > 0.599* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSXMAP00000003984	Homeodomain	67	123	RRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRK

Links
Other Homeodomain family TFs
Other *Xiphophorus maculatus* TFs

1139 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action
AAEL007450	Aedes aegypti	AAEL007450	I
AATE006351	Anopheles atroparvus	AATE006351	I
ACOM030734	Anopheles coluzzii	ACOM030734	I
ACUA009853	Anopheles culicifacies	ACUA009853	I
ADAC003639	Anopheles darlingi	ADAC003639	I
AFAF010941	Anopheles farauti	AFAF010941	I
AFUN006321	Anopheles funestus	AFUN006321	I
ODDA	Anopheles gambiae	AGAP007972	I
ODDB	Anopheles gambiae	AGAP012585	I
AMAM023036	Anopheles maculatus	AMAM023036	I
AMEC015679	Anopheles melas	AMEC015679	I
AMEC006880	Anopheles melas	AMEC006880	I
AMEM014670	Anopheles merus	AMEM014670	I
AQUA000694	Anopheles quadriannulatus	AQUA000694	I
ASTEI01737	Anopheles stephensi	ASTEI01737	I
CpipJ_CPIJ010649	Culex pipiens	CpipJ_CPIJ010649	I
CPIJ010649	Culex quinquefasciatus	CPIJ010649	I
GF14661	Drosophila ananassae	FBgn0091688	I
GG24424	Drosophila erecta	FBgn0116556	I
GH13191	Drosophila grimshawi	FBgn0120668	I
odd	Drosophila melanogaster	FBgn0002985	D
GI17766	Drosophila mojavensis	FBgn0140507	I
GA17731	Drosophila pseudoobscura	FBgn0077741	I
GM18135	Drosophila sechellia	FBgn0173042	I
GD22743	Drosophila simulans	FBgn0194139	I
GJ17592	Drosophila virilis	FBgn0204762	I
GK15475	Drosophila willistoni	FBgn0217480	I
GE14830	Drosophila yakuba	FBgn0232422	I
LLOJ001734	Lutzomyia longipalpis	LLOJ001734	I
MESCA009141	Megaselia scalaris	MESCA009141	I
MDOA000040	Musca domestica	MDOA000040	I
MDOA004014	Musca domestica	MDOA004014	I
MDOA008133	Musca domestica	MDOA008133	I

ENSXMAG00000003977 (Xiphophorus maculatus) Homeodomain

TF Information

Directly determined binding motifs

Motifs from related TFs

DNA Binding Domains

Links

1139 Related TFs

ENSXMAG00000003977 **(Xiphophorus maculatus)
Homeodomain**