CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
Home
Tools
View cart
Bulk downloads
Database stats
Contact us
Help
Update Log
FAQ
Links
How to cite
unc-62
(
Caenorhabditis elegans
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
WBGene00006796
T224647_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; muscle cell differentiation; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within lipid homeostasis. Located in chromatin and nucleus. Is expressed in several structures, including body wall musculature; hypodermis; neurons; reproductive system; and vulval precursor cell. Used to study leukemia and restless legs syndrome. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to several human genes including MEIS1 (Meis homeobox 1) and MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
unc-62
M02185_2.00
Caenorhabditis elegans
NHDAHANNN
NNNTDTHDN
PBM
Weirauch et al.(2014)
pTH5781
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
MEIS3
M03093_2.00
Homo sapiens
DTGACANN
NNTGTCAH
SELEX
Jolma et al.(2013)
MEIS3_1
0.842
0.842
CBG24578
M02065_2.00
Caenorhabditis briggsae
NNNTGACAKSTN
NASMTGTCANNN
PBM
Weirauch et al.(2014)
pTH6524
0.866
0.982
MEIS3
M03094_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
MEIS3_2
0.842
0.842
Meis1
M00407_2.00
Mus musculus
NTGACADNN
NNHTGTCAN
PBM
Berger et al.(2008)
Meis1_2335
0.778
0.818
MEIS3
M04951_2.00
Homo sapiens
TGWCABVTGWCA
TGWCABVTGWCA
SELEX
Yin et al.(2017)
MEIS3_eDBD_HT-SELEX
0.842
0.842
Meis2
M00437_2.00
Mus musculus
NTGACANNN
NNNTGTCAN
PBM
Berger et al.(2008)
Mrg1_2246
0.778
0.818
MEIS3
M04952_2.00
Homo sapiens
YGWCABVTGWCR
YGWCABVTGWCR
SELEX
Yin et al.(2017)
MEIS3_eDBD_Methyl-HT-SELEX
0.842
0.842
Meis3
M00488_2.00
Mus musculus
NTGACANNN
NNNTGTCAN
PBM
Berger et al.(2008)
Mrg2_2302
0.778
0.818
Q5EVH4_OIKDI
M02227_2.00
Oikopleura dioica
NTGACAKN
NMTGTCAN
PBM
Weirauch et al.(2014)
pTH6041
0.767
0.737
MEIS1
M03165_2.00
Homo sapiens
NTGACAN
NTGTCAN
SELEX
Jolma et al.(2013)
MEIS1_1
0.778
0.818
KNAT7
M01064_2.00
Arabidopsis thaliana
TGACRKST
ASMYGTCA
PBM
Sullivan et al.(2014)
pTH9798
0.671
0.500
MEIS2
M03147_2.00
Homo sapiens
WTGACAGSTGTCAM
KTGACASCTGTCAW
SELEX
Jolma et al.(2013)
MEIS2_1
0.778
0.818
MEIS2
M03148_2.00
Homo sapiens
DTGACAGS
SCTGTCAH
SELEX
Jolma et al.(2013)
MEIS2_2
0.778
0.818
KNAT4
M01238_2.00
Arabidopsis thaliana
NNGACNNNN
NNNNGTCNN
PBM
Lambert et al.(2019)
pTH9968
0.667
0.526
Meis2
M03261_2.00
Mus musculus
NTGACAN
NTGTCAN
SELEX
Jolma et al.(2013)
Meis2_1
0.778
0.818
KNAT3
M02051_2.00
Arabidopsis thaliana
NNNGACVBNN
NNVBGTCNNN
PBM
Weirauch et al.(2014)
pTH7600
0.667
0.526
HOS66
M02156_2.00
Oryza sativa
NNNNDHNN
NNDHNNNN
PBM
Weirauch et al.(2014)
pTH8332
0.632
0.500
Meis2
M03262_2.00
Mus musculus
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
Meis2_2
0.778
0.818
ATH1
M10627_2.00
Arabidopsis thaliana
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$ATH1_01
0.604
0.579
Meis3
M03279_2.00
Mus musculus
NTGACAN
NTGTCAN
SELEX
Jolma et al.(2013)
Meis3_1
0.778
0.818
Meis3
M03280_2.00
Mus musculus
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
Meis3_2
0.778
0.818
MEIS2
M02740_2.00
Homo sapiens
TGACASSTGTC
GACASSTGTCA
SELEX
Jolma et al.(2010)
MEIS2_dimer
0.778
0.818
MEIS2
M02741_2.00
Homo sapiens
GGACAKNT
ANMTGTCC
SELEX
Jolma et al.(2010)
MEIS2_monomer
0.778
0.818
MEIS2
M05138_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
MEIS2_eDBD_HT-SELEX
0.778
0.818
MEIS2
M05140_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
MEIS2_FL_HT-SELEX
0.778
0.818
hth
M06490_2.00
Drosophila melanogaster
TGACAK
MTGTCA
B1H
Mathelier et al.(2014)
MA0227.1
0.778
0.818
hth
M06252_2.00
Drosophila melanogaster
TGTCA
TGACA
B1H
Zhu et al.(2011)
Hth_Cell_FBgn0001235
0.778
0.818
hth
M06253_2.00
Drosophila melanogaster
NNTGACAD
HTGTCANN
B1H
Zhu et al.(2011)
hth_SOLEXA_2_FBgn0001235
0.778
0.818
hth
M06254_2.00
Drosophila melanogaster
NTGACA
TGTCAN
B1H
Zhu et al.(2011)
Hth_SOLEXA_FBgn0001235
0.778
0.818
MEIS1
M09148_2.00
Homo sapiens
NTGATTDATDDB
VHHATHAATCAN
Misc
Kulakovskiy et al.(2013)
MEIS1_HUMAN.H11MO.0.A
0.778
0.818
MEIS2
M09143_2.00
Homo sapiens
HTGACAGBTKTBM
KVAMAVCTGTCAD
Misc
Kulakovskiy et al.(2013)
MEIS2_HUMAN.H11MO.0.B
0.778
0.818
Meis1
M09178_2.00
Mus musculus
NTGATTDATDDB
VHHATHAATCAN
Misc
Kulakovskiy et al.(2013)
MEIS1_MOUSE.H11MO.0.A
0.778
0.818
Meis2
M09189_2.00
Mus musculus
HTGACAGBTKTBM
KVAMAVCTGTCAD
Misc
Kulakovskiy et al.(2013)
MEIS2_MOUSE.H11MO.0.B
0.778
0.818
Meis1
M09568_2.00
Mus musculus
VBTGWCASNN
NNSTGWCAVB
Misc
Heinz et al.(2010)
MastCells-Meis1_GSE48085
0.778
0.818
MEIS1
M10709_2.00
Homo sapiens
NHNTGACAGNDN
NHNCTGTCANDN
Transfac
Matys et al.(2006)
V$MEIS1_01
0.778
0.818
MEIS1
M10710_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEIS1_06
0.778
0.818
MEIS2
M05139_2.00
Homo sapiens
YGACASSYGHCR
YGDCRSSTGTCR
SELEX
Yin et al.(2017)
MEIS2_eDBD_Methyl-HT-SELEX
0.778
0.818
MEIS2
M05141_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
MEIS2_FL_Methyl-HT-SELEX
0.778
0.818
Pknox1
M00399_2.00
Mus musculus
HGACRNNN
NNNYGTCD
PBM
Berger et al.(2008)
Pknox1_2364
0.738
0.673
PKNOX1
M03178_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
PKNOX1_1
0.738
0.673
PKNOX1
M05206_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
PKNOX1_eDBD_HT-SELEX
0.738
0.673
PKNOX1
M05208_2.00
Homo sapiens
TGACAGCTGTCA
TGACAGCTGTCA
SELEX
Yin et al.(2017)
PKNOX1_FL_HT-SELEX
0.738
0.673
PKNOX1
M09150_2.00
Homo sapiens
TGABTGRCRGV
BCYGYCAVTCA
Misc
Kulakovskiy et al.(2013)
PKNX1_HUMAN.H11MO.0.B
0.738
0.673
Pknox1
M09175_2.00
Mus musculus
TGABTGRCRGV
BCYGYCAVTCA
Misc
Kulakovskiy et al.(2013)
PKNX1_MOUSE.H11MO.0.A
0.738
0.673
PKNOX1
M10712_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PREP1_Q3
0.738
0.673
PKNOX1
M05207_2.00
Homo sapiens
YGWCASSTGWCR
YGWCASSTGWCR
SELEX
Yin et al.(2017)
PKNOX1_eDBD_Methyl-HT-SELEX
0.738
0.673
PKNOX1
M05209_2.00
Homo sapiens
TGACABVTGTCA
TGACABVTGTCA
SELEX
Yin et al.(2017)
PKNOX1_FL_Methyl-HT-SELEX
0.738
0.673
Pknox2
M00468_2.00
Mus musculus
NNNGACRNNN
NNNYGTCNNN
PBM
Berger et al.(2008)
Pknox2_3077
0.738
0.655
PKNOX2
M03195_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
PKNOX2_1
0.738
0.655
Pknox2
M03270_2.00
Mus musculus
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
Pknox2_1
0.738
0.655
PKNOX2
M05246_2.00
Homo sapiens
TGACABVTGTCA
TGACABVTGTCA
SELEX
Yin et al.(2017)
PKNOX2_eDBD_HT-SELEX
0.738
0.655
PKNOX2
M05247_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
PKNOX2_eDBD_Methyl-HT-SELEX
0.738
0.655
Tgif1
M00500_2.00
Mus musculus
NNTGACANNN
NNNTGTCANN
PBM
Berger et al.(2008)
Tgif1_2342
0.652
0.509
TGIF1
M03223_2.00
Homo sapiens
TGACAGCTGTCA
TGACAGCTGTCA
SELEX
Jolma et al.(2013)
TGIF1_1
0.652
0.509
TGIF1
M05317_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Yin et al.(2017)
TGIF1_eDBD_HT-SELEX
0.652
0.509
TGIF1
M09159_2.00
Homo sapiens
TGACAGS
SCTGTCA
Misc
Kulakovskiy et al.(2013)
TGIF1_HUMAN.H11MO.0.A
0.652
0.509
Tgif1
M09211_2.00
Mus musculus
TGACAGBNV
BNVCTGTCA
Misc
Kulakovskiy et al.(2013)
TGIF1_MOUSE.H11MO.0.A
0.652
0.509
TGIF1
M10740_2.00
Homo sapiens
WHNTGACARST
ASYTGTCANDW
Transfac
Matys et al.(2006)
V$TGIF_01
0.652
0.509
TGIF1
M05318_2.00
Homo sapiens
TGACAKVTGTCA
TGACABMTGTCA
SELEX
Yin et al.(2017)
TGIF1_eDBD_Methyl-HT-SELEX
0.652
0.509
achi
M03860_2.00
Drosophila melanogaster
TGACAD
HTGTCA
SELEX
Nitta et al.(2015)
achi_1
0.632
0.491
achi
M03861_2.00
Drosophila melanogaster
TGACAGMTGTCA
TGACAKCTGTCA
SELEX
Nitta et al.(2015)
achi_2
0.632
0.491
achi
M03862_2.00
Drosophila melanogaster
TGACAGNNNNNNYGTCA
TGACRNNNNNNCTGTCA
SELEX
Nitta et al.(2015)
achi_3
0.632
0.491
vis
M03859_2.00
Drosophila melanogaster
TGACAS
STGTCA
SELEX
Nitta et al.(2015)
vis_1
0.632
0.491
vis
M06534_2.00
Drosophila melanogaster
TGACAB
BTGTCA
B1H
Mathelier et al.(2014)
MA0252.1
0.632
0.491
achi
M06535_2.00
Drosophila melanogaster
TGACAG
CTGTCA
B1H
Mathelier et al.(2014)
MA0207.1
0.632
0.491
achi
M06345_2.00
Drosophila melanogaster
TGTCADW
WHTGACA
B1H
Zhu et al.(2011)
Achi_Cell_FBgn0033749
0.632
0.491
achi
M06346_2.00
Drosophila melanogaster
HTGACA
TGTCAD
B1H
Zhu et al.(2011)
Achi_SOLEXA_FBgn0033749
0.632
0.491
vis
M06343_2.00
Drosophila melanogaster
TGTCA
TGACA
B1H
Zhu et al.(2011)
Vis_Cell_FBgn0033748
0.632
0.491
vis
M06344_2.00
Drosophila melanogaster
TGTCAD
HTGACA
B1H
Zhu et al.(2011)
Vis_SOLEXA_FBgn0033748
0.632
0.491
Tgif2
M00521_2.00
Mus musculus
NNTGACANNN
NNNTGTCANN
PBM
Berger et al.(2008)
Tgif2_3451
0.620
0.473
TGIF2
M03123_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
TGIF2_1
0.620
0.473
TGIF2
M05032_2.00
Homo sapiens
TGACABVTGTCA
TGACABVTGTCA
SELEX
Yin et al.(2017)
TGIF2_eDBD_HT-SELEX
0.620
0.473
TGIF2
M05034_2.00
Homo sapiens
DTGACANN
NNTGTCAH
SELEX
Yin et al.(2017)
TGIF2_FL_HT-SELEX
0.620
0.473
TGIF2
M05033_2.00
Homo sapiens
TGWCABVTGWCA
TGWCABVTGWCA
SELEX
Yin et al.(2017)
TGIF2_eDBD_Methyl-HT-SELEX
0.620
0.473
TGIF2
M05035_2.00
Homo sapiens
DTGACANN
NNTGTCAH
SELEX
Yin et al.(2017)
TGIF2_FL_Methyl-HT-SELEX
0.620
0.473
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M02185_2.00
Homeodomain
1
58
SRGRGIFPKQATNRLRQWLFQNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
T28F12.2a
Homeodomain
393
450
RKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2b.1
Homeodomain
356
413
RKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2b.2
Homeodomain
356
413
RKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2c
Homeodomain
1
39
MFNFQHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2e
Homeodomain
352
409
SRGRGIFPKQATNRLRQWLFQNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2f
Homeodomain
389
446
SRGRGIFPKQATNRLRQWLFQNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2g.1
Homeodomain
319
376
RKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
T28F12.2g.2
Homeodomain
319
376
RKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRI
Links
Other
Homeodomain
family TFs
Other
Caenorhabditis elegans
TFs
2051 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy