nkx2-8 (Xenopus tropicalis)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox) IPR001356 XB-GENE-853981 T230624_2.00 Misc (2018-Jan-19)

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.837 0.912
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.837 0.912
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.837 0.912
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.837 0.912
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.837 0.912
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.837 0.912
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.837 0.895
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.814 0.860
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.814 0.860
NKX2-2
M10681_2.00 		Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01 		0.814 0.860
NKX2-2
M10682_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01 		0.814 0.860
NKX2-2
M10683_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3 		0.814 0.860
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.805 0.895
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.805 0.895
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.805 0.895
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.798 0.825
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.798 0.825
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.798 0.825
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.798 0.825
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.798 0.825
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.766 0.772
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.761 0.807
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.761 0.807
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.761 0.807
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.761 0.807
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.761 0.807
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.761 0.807
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.761 0.807
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.761 0.807
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.761 0.807
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.750 0.789
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.743 0.754
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.715 0.789
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.715 0.789
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.715 0.789
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.715 0.789
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.715 0.789
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.715 0.789
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.715 0.789
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.715 0.789
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.715 0.789
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.715 0.789
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.715 0.789
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.715 0.789
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.715 0.789
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.715 0.789
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.715 0.772
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.715 0.772
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.715 0.754
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.715 0.754
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.715 0.754
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.715 0.754
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.715 0.754
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.715 0.754
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.715 0.754
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.710 0.632
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.710 0.772
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.694 0.719
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.694 0.632
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.694 0.632
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.694 0.632
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.694 0.632
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.694 0.632
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.694 0.632
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.682 0.772
Q24782_9CNID
M02206_2.00 		Eleutheria dichotoma
TTAATTAA
TTAATTAA		 PBM
Weirauch et al.(2014)
pTH5486 		0.607 0.491
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
AAH61321 Homeodomain 83 139

Links

Other Homeodomain family TFs
Other Xenopus tropicalis TFs

797 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
F775_00942 Aegilops tauschii F775_00942 N
F775_07224 Aegilops tauschii F775_07224 I
F775_12735 Aegilops tauschii F775_12735 N
F775_16517 Aegilops tauschii F775_16517 N
F775_52611 Aegilops tauschii F775_52611 N
BRADI1G52187 Brachypodium distachyon BRADI1G52187 I
BRADI3G13117 Brachypodium distachyon BRADI3G13117 N
BRADI5G27467 Brachypodium distachyon BRADI5G27467 N
MLOC_19933 Hordeum vulgare MLOC_19933 N
MLOC_67250 Hordeum vulgare MLOC_67250 N
MLOC_66083 Hordeum vulgare MLOC_66083 N
MLOC_53086 Hordeum vulgare MLOC_53086 I
LPERR08G00380 Leersia perrieri LPERR08G00380 N
LPERR06G00240 Leersia perrieri LPERR06G00240 I
LPERR04G16200 Leersia perrieri LPERR04G16200 I
GSMUA_Achr3G22360_001 Musa acuminata GSMUA_Achr3G22360_001 N
GSMUA_Achr8G11590_001 Musa acuminata GSMUA_Achr8G11590_001 I
OBART08G00290 Oryza barthii OBART08G00290 N
OBART06G00240 Oryza barthii OBART06G00240 I
OBART04G20020 Oryza barthii OBART04G20020 I
OB04G27030 Oryza brachyantha OB04G27030 I
OB06G10310 Oryza brachyantha OB06G10310 I
OB08G10370 Oryza brachyantha OB08G10370 N
ORGLA04G0171200 Oryza glaberrima ORGLA04G0171200 I
ORGLA04G0270600 Oryza glaberrima ORGLA04G0270600 I
ORGLA06G0002300 Oryza glaberrima ORGLA06G0002300 I
OGLUM04G19900 Oryza glumaepatula OGLUM04G19900 I
OGLUM04G30580 Oryza glumaepatula OGLUM04G30580 I
OGLUM06G00210 Oryza glumaepatula OGLUM06G00210 I
OGLUM08G00350 Oryza glumaepatula OGLUM08G00350 N
BGIOSGA014034 Oryza indica BGIOSGA014034 I
BGIOSGA027807 Oryza indica BGIOSGA027807 N
BGIOSGA022108 Oryza indica BGIOSGA022108 I
BGIOSGA014649 Oryza indica BGIOSGA014649 I
OMERI03G30800 Oryza meridionalis OMERI03G30800 I
OMERI04G25730 Oryza meridionalis OMERI04G25730 I
OMERI06G00230 Oryza meridionalis OMERI06G00230 I
OMERI08G00600 Oryza meridionalis OMERI08G00600 N
ONIVA08G00280 Oryza nivara ONIVA08G00280 N
ONIVA04G18230 Oryza nivara ONIVA04G18230 I
ONIVA04G29890 Oryza nivara ONIVA04G29890 I
ONIVA06G00260 Oryza nivara ONIVA06G00260 I
OPUNC06G00220 Oryza punctata OPUNC06G00220 I
OPUNC08G00360 Oryza punctata OPUNC08G00360 N
OPUNC04G17680 Oryza punctata OPUNC04G17680 I
ORUFI08G00330 Oryza rufipogon ORUFI08G00330 N
ORUFI06G00250 Oryza rufipogon ORUFI06G00250 I
ORUFI04G21580 Oryza rufipogon ORUFI04G21580 I
ORUFI04G32410 Oryza rufipogon ORUFI04G32410 I
OS08G0103900 Oryza sativa OS08G0103900 N
OS06G0104200 Oryza sativa OS06G0104200 I
OS04G0691300 Oryza sativa OS04G0691300 I
OS04G0536500 Oryza sativa OS04G0536500 I
Pavir.J31179 Panicum virgatum Pavir.J31179 N
Pavir.Da02426 Panicum virgatum Pavir.Da02426 I
Pavir.Gb00744 Panicum virgatum Pavir.Gb00744 I
Pavir.J07126 Panicum virgatum Pavir.J07126 I
Pavir.J20890 Panicum virgatum Pavir.J20890 N
Pavir.J26987 Panicum virgatum Pavir.J26987 I
e_gw1.70.85.1 Physcomitrella patens e_gw1.70.85.1 N
SELMODRAFT_402243 Selaginella moellendorffii SELMODRAFT_402243 I
SELMODRAFT_408624 Selaginella moellendorffii SELMODRAFT_408624 I
Si014149m.g Setaria italica Si014149m.g N
Si010504m.g Setaria italica Si010504m.g I
Si006829m.g Setaria italica Si006829m.g I
Sb06g023780 Sorghum bicolor Sb06g023780 I
Sb10g000460 Sorghum bicolor Sb10g000460 I
Sb07g000470 Sorghum bicolor Sb07g000470 N
Sb06g034010 Sorghum bicolor Sb06g034010 N
Traes_2AL_8EE7F34F6 Triticum aestivum Traes_2AL_8EE7F34F6 N
Traes_7DS_7F0AF83B0 Triticum aestivum Traes_7DS_7F0AF83B0 I
Traes_7DL_DF64397D7 Triticum aestivum Traes_7DL_DF64397D7 N
Traes_7AS_6398221B7 Triticum aestivum Traes_7AS_6398221B7 I
Traes_4AL_F853C8660 Triticum aestivum Traes_4AL_F853C8660 I
Traes_2DL_607AD3522 Triticum aestivum Traes_2DL_607AD3522 N
Traes_2BL_0AED4E377 Triticum aestivum Traes_2BL_0AED4E377 N
Traes_2AL_F001B4F26 Triticum aestivum Traes_2AL_F001B4F26 N
Traes_2AL_CB84F42D2 Triticum aestivum Traes_2AL_CB84F42D2 N
Traes_2AL_C0670BBDD Triticum aestivum Traes_2AL_C0670BBDD N
Traes_2BL_CBFB7D720 Triticum aestivum Traes_2BL_CBFB7D720 N
TRIUR3_24878 Triticum urartu TRIUR3_24878 N
TRIUR3_24879 Triticum urartu TRIUR3_24879 N
TRIUR3_10971 Triticum urartu TRIUR3_10971 N
TRIUR3_10969 Triticum urartu TRIUR3_10969 N
TRIUR3_08851 Triticum urartu TRIUR3_08851 I
TRIUR3_06372 Triticum urartu TRIUR3_06372 N
GRMZM2G440219 Zea mays GRMZM2G440219 I
GRMZM2G041668 Zea mays GRMZM2G041668 I
GRMZM2G048826 Zea mays GRMZM2G048826 N
GRMZM2G052239 Zea mays GRMZM2G052239 I
GRMZM2G178998 Zea mays GRMZM2G178998 I
GRMZM2G354151 Zea mays GRMZM2G354151 I
AC212859.3_FG008 Zea mays AC212859.3_FG008 N