| NCBI Gene Info:Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in aortic valve disease 2; colorectal cancer; craniosynostosis; pancreatic adenocarcinoma; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Apr 2022] |