TBX5 (Homo sapiens)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSG00000089225 T339886_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TBX5
M03552_2.00		 Homo sapiens
AGGTGTBA
TVACACCT		 SELEX
Jolma et al.(2013)
TBX5_1		 (Direct) (Direct)
TBX5
M03553_2.00		 Homo sapiens
AGGTGTKANWWNTVACACCT
AGGTGTBANWWNTMACACCT		 SELEX
Jolma et al.(2013)
TBX5_2		 (Direct) (Direct)
TBX5
M11374_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_01		 (Direct) (Direct)
TBX5
M11375_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_02		 (Direct) (Direct)
TBX5
M11376_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_Q2		 (Direct) (Direct)
TBX5
M11377_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_Q5		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbx5
M00833_2.00 		Mus musculus
AGGTGTBA
TVACACCT		 PBM
Weirauch et al.(2013)
pTH3775 		0.920 1.000
Tbx5
M09649_2.00 		Mus musculus
AGGTGHBA
TVDCACCT		 Misc
Heinz et al.(2010)
HL1-Tbx5.biotin_GSE21529 		0.920 1.000
Tbx5
M11387_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX5_05 		0.920 1.000
Tbx4
M00831_2.00 		Mus musculus
AGGTGTBA
TVACACCT		 PBM
Weirauch et al.(2013)
pTH3973 		0.899 0.934
TBX4
M03558_2.00 		Homo sapiens
AGGTGTBA
TVACACCT		 SELEX
Jolma et al.(2013)
TBX4_1 		0.899 0.934
TBX4
M03559_2.00 		Homo sapiens
AGGTGTBANWWNTVACACBT
AVGTGTBANWWNTVACACCT		 SELEX
Jolma et al.(2013)
TBX4_2 		0.899 0.934
XP_008203914.1
M01029_2.00 		Nasonia vitripennis
AGGTGTBA
TVACACCT		 PBM
SebePedros et al.(2013)
pTH9336 		0.804 0.615
Tbx2
M00830_2.00 		Mus musculus
NYVDCACBHN
NDVGTGHBRN		 PBM
Weirauch et al.(2013)
pTH3751 		0.799 0.654
TBX2
M03556_2.00 		Homo sapiens
GGTGTKADDWNTVACACB
VGTGTBANWHHTMACACC		 SELEX
Jolma et al.(2013)
TBX2_1 		0.799 0.654
TBX2
M03557_2.00 		Homo sapiens
NAGGTGTBAWN
NWTVACACCTN		 SELEX
Jolma et al.(2013)
TBX2_2 		0.799 0.654
TBX2
M05799_2.00 		Homo sapiens
NNVRCRCNNN
NNNGYGYBNN		 SELEX
Yin et al.(2017)
TBX2_eDBD_HT-SELEX 		0.799 0.654
Tbx2
M08044_2.00 		Mus musculus
GCHYBCTGGGADHTGTAGTYH
DRACTACADHTCCCAGVRDGC		 ChIP-seq
Chen et al.(2011)
SRP001585_Tbx2 		0.799 0.654
TBX2
M11381_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX2_Q2 		0.799 0.654
TBX2
M11382_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX2_Q5 		0.799 0.654
TBX2
M05800_2.00 		Homo sapiens
NNVRCRCBNN
NNVGYGYBNN		 SELEX
Yin et al.(2017)
TBX2_eDBD_Methyl-HT-SELEX 		0.799 0.654
Tbx3
M00834_2.00 		Mus musculus
NHNDCACNHN
NDNGTGHNDN		 PBM
Weirauch et al.(2013)
pTH3998 		0.797 0.637
TBX3
M05801_2.00 		Homo sapiens
NDSGTGTBRN
NYVACACSHN		 SELEX
Yin et al.(2017)
TBX3_eDBD_HT-SELEX 		0.797 0.637
TBX3
M09426_2.00 		Homo sapiens
DVDGGTGBNAR
YTNVCACCHBH		 Misc
Kulakovskiy et al.(2013)
TBX3_HUMAN.H11MO.0.C 		0.797 0.637
Tbx3
M09429_2.00 		Mus musculus
RRGGTGBBR
YVVCACCYY		 Misc
Kulakovskiy et al.(2013)
TBX3_MOUSE.H11MO.0.B 		0.797 0.637
TBX3
M05802_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX3_eDBD_Methyl-HT-SELEX 		0.797 0.637
XP_001195863
M02498_2.00 		Strongylocentrotus purpuratus
AGGTGTBA
TVACACCT		 PBM
Weirauch et al.(2014)
pTH9340 		0.793 0.692
estExt_fgenesh2_pg.C_1570024
M01030_2.00 		Branchiostoma floridae
NHNDCACNHN
NDNGTGHNDN		 PBM
SebePedros et al.(2013)
pTH9244 		0.787 0.681
TBX2
M02495_2.00 		Gasterosteus aculeatus
NNVDCACNHN
NDNGTGHBNN		 PBM
Weirauch et al.(2014)
pTH9182 		0.767 0.637
TBX2
M02496_2.00 		Takifugu rubripes
DAGGTGTBRN
NYVACACCTH		 PBM
Weirauch et al.(2014)
pTH9289 		0.767 0.632
Tbx20
M00835_2.00 		Mus musculus
NRRGTGTBAN
NTVACACYYN		 PBM
Weirauch et al.(2013)
pTH3777 		0.754 0.610
TBX20
M03565_2.00 		Homo sapiens
AGGTGTKARVGYGTGA
TCACRCBYTMACACCT		 SELEX
Jolma et al.(2013)
TBX20_1 		0.754 0.610
TBX20
M03566_2.00 		Homo sapiens
AGGTGTGAAWDTSACACBT
AVGTGTSAHWTTCACACCT		 SELEX
Jolma et al.(2013)
TBX20_2 		0.754 0.610
TBX20
M03567_2.00 		Homo sapiens
NNNDAGGTGTGAAND
HNTTCACACCTHNNN		 SELEX
Jolma et al.(2013)
TBX20_3 		0.754 0.610
TBX20
M03568_2.00 		Homo sapiens
DAGGTGTGAWR
YWTCACACCTH		 SELEX
Jolma et al.(2013)
TBX20_4 		0.754 0.610
TBX20
M03569_2.00 		Homo sapiens
AGGTGTKANGKTGTSA
TSACAMCNTMACACCT		 SELEX
Jolma et al.(2013)
TBX20_5 		0.754 0.610
TBX20
M05813_2.00 		Homo sapiens
DAGGTGTKARSGTGTGAA
TTCACACSYTMACACCTH		 SELEX
Yin et al.(2017)
TBX20_eDBD_HT-SELEX_1 		0.754 0.610
TBX20
M05814_2.00 		Homo sapiens
NAGGTGTGAAWTTCACACCTN
NAGGTGTGAAWTTCACACCTN		 SELEX
Yin et al.(2017)
TBX20_eDBD_HT-SELEX_2 		0.754 0.610
TBX20
M05817_2.00 		Homo sapiens
DRRGTGTBADVGYGTBAN
NTVACRCBHTVACACYYH		 SELEX
Yin et al.(2017)
TBX20_FL_HT-SELEX_1 		0.754 0.610
TBX20
M05818_2.00 		Homo sapiens
WTCACACYTAGGTGTKAM
KTMACACCTARGTGTGAW		 SELEX
Yin et al.(2017)
TBX20_FL_HT-SELEX_2 		0.754 0.610
Tbx20
M09430_2.00 		Mus musculus
NDSTGNTGACAGSN
NSCTGTCANCASHN		 Misc
Kulakovskiy et al.(2013)
TBX20_MOUSE.H11MO.0.C 		0.754 0.610
Tbx20
M09650_2.00 		Mus musculus
SCTGTCADCASN
NSTGHTGACAGS		 Misc
Heinz et al.(2010)
Heart-Tbx20_GSE29636 		0.754 0.610
TBX20
M11385_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX20_05 		0.754 0.610
TBX20
M05815_2.00 		Homo sapiens
DAGGTGTKAASGYGTKAA
TTMACRCSTTMACACCTH		 SELEX
Yin et al.(2017)
TBX20_eDBD_Methyl-HT-SELEX_1 		0.754 0.610
TBX20
M05816_2.00 		Homo sapiens
DASGTGTGAWWWTCACACCTH
DAGGTGTGAWWWTCACACSTH		 SELEX
Yin et al.(2017)
TBX20_eDBD_Methyl-HT-SELEX_2 		0.754 0.610
TBX20
M05819_2.00 		Homo sapiens
DRGGYGTBARVGYGTKAN
NTMACRCBYTVACRCCYH		 SELEX
Yin et al.(2017)
TBX20_FL_Methyl-HT-SELEX_1 		0.754 0.610
TBX20
M05820_2.00 		Homo sapiens
TTMACRCCTAVGTGTGAA
TTCACACBTAGGYGTKAA		 SELEX
Yin et al.(2017)
TBX20_FL_Methyl-HT-SELEX_2 		0.754 0.610
Eomes
M00215_2.00 		Mus musculus
RDGTGYBANN
NNTVRCACHY		 PBM
Badis et al.(2009)
Eomes_0921 		0.739 0.549
EOMES
M03563_2.00 		Homo sapiens
DAGGTGTGAWNNN
NNNWTCACACCTH		 SELEX
Jolma et al.(2013)
EOMES_1 		0.739 0.544
EOMES
M03564_2.00 		Homo sapiens
TVACACNTNNNDRNGTGTGA
TCACACNYHNNNANGTGTBA		 SELEX
Jolma et al.(2013)
EOMES_2 		0.739 0.544
EOMES
M02752_2.00 		Homo sapiens
AGGTGTGAW
WTCACACCT		 SELEX
Jolma et al.(2010)
EOMES_monomer 		0.739 0.544
EOMES
M05807_2.00 		Homo sapiens
DAGGTGTGAN
NTCACACCTH		 SELEX
Yin et al.(2017)
EOMES_eDBD_HT-SELEX 		0.739 0.544
EOMES
M09647_2.00 		Homo sapiens
ARGTGWKAAN
NTTMWCACYT		 Misc
Heinz et al.(2010)
H9-Eomes_GSE26097 		0.739 0.544
EOMES
M05808_2.00 		Homo sapiens
NABGTGYKAH
DTMRCACVTN		 SELEX
Yin et al.(2017)
EOMES_eDBD_Methyl-HT-SELEX 		0.739 0.544
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000309913 T-box 56 238
ENSP00000337723 T-box 6 188
ENSP00000384152 T-box 56 238
ENSP00000433292 T-box 56 238

Links

Other T-box family TFs
Other Homo sapiens TFs

417 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMEG00000013799 Ailuropoda melanoleuca ENSAMEG00000013799 I
ENSAMEG00000015392 Ailuropoda melanoleuca ENSAMEG00000015392 I
Alligator_sinensis_CCG004936.1 Alligator sinensis Alligator_sinensis_CCG004936.1 I
Alligator_sinensis_CCG016555.1 Alligator sinensis Alligator_sinensis_CCG016555.1 I
ENSAPLG00000002588 Anas platyrhynchos ENSAPLG00000002588 I
ENSAPLG00000004382 Anas platyrhynchos ENSAPLG00000004382 I
CUX2 Anolis carolinensis ENSACAG00000002281 I
CUX1 Anolis carolinensis ENSACAG00000015088 I
Afo_R009437 Aptenodytes forsteri Afo_R009437 I
ENSAMXG00000006105 Astyanax mexicanus ENSAMXG00000006105 I
ENSAMXG00000008817 Astyanax mexicanus ENSAMXG00000008817 I
ENSP00000261726-D1 Bos grunniens ENSP00000261726-D1 I
ENSP00000353401-D1 Bos grunniens ENSP00000353401-D1 I
CUX2 Bos taurus ENSBTAG00000008571 I
CUX1 Bos taurus ENSBTAG00000010659 I
CUX2 Callithrix jacchus ENSCJAG00000011694 I
CUX1 Callithrix jacchus ENSCJAG00000016076 I
Aan_R003487 Calypte anna Aan_R003487 I
Aan_R010335 Calypte anna Aan_R010335 I
CUX2 Canis familiaris ENSCAFG00000008575 I
CUX1 Canis familiaris ENSCAFG00000013749 D
CUX2 Cavia porcellus ENSCPOG00000020483 I
Cmyd_10006308 Chelonia mydas Cmyd_10006308 I
Cmyd_10015658 Chelonia mydas Cmyd_10015658 I
ENSCSAG00000018062 Chlorocebus sabaeus ENSCSAG00000018062 I
cux1a Danio rerio ENSDARG00000078459 I
cux2b Danio rerio ENSDARG00000086345 I
CUX2 Dasypus novemcinctus ENSDNOG00000039959 I
ENSDNOG00000032548 Dasypus novemcinctus ENSDNOG00000032548 I
ENSECAG00000007841 Equus caballus ENSECAG00000007841 I
CUX1 Erinaceus europaeus ENSEEUG00000005128 I
CUX2 Felis catus ENSFCAG00000003176 I
CUX1 Felis catus ENSFCAG00000008074 I
ENSFALG00000009019 Ficedula albicollis ENSFALG00000009019 I
ENSFALG00000009409 Ficedula albicollis ENSFALG00000009409 I
ENSGMOG00000008990 Gadus morhua ENSGMOG00000008990 I
ENSGMOG00000017485 Gadus morhua ENSGMOG00000017485 I
ENSGALG00000001807 Gallus gallus ENSGALG00000001807 I
CUX2 Gallus gallus ENSGALG00000004598 I
ENSGACG00000009915 Gasterosteus aculeatus ENSGACG00000009915 I
cux2b Gasterosteus aculeatus ENSGACG00000013522 I
Gfo_R003142 Geospiza fortis Gfo_R003142 I
Gfo_R011360 Geospiza fortis Gfo_R011360 I
ENSGGOG00000016960 Gorilla gorilla ENSGGOG00000016960 I
CUX2 Homo sapiens ENSG00000111249 D
CUX1 Homo sapiens ENSG00000257923 D
ENSSTOG00000002242 Ictidomys tridecemlineatus ENSSTOG00000002242 I
ENSSTOG00000010390 Ictidomys tridecemlineatus ENSSTOG00000010390 I
ENSLACG00000014413 Latimeria chalumnae ENSLACG00000014413 I
ENSLACG00000017710 Latimeria chalumnae ENSLACG00000017710 I
ENSLOCG00000001531 Lepisosteus oculatus ENSLOCG00000001531 I
ENSLOCG00000007417 Lepisosteus oculatus ENSLOCG00000007417 I
CUX2 Loxodonta africana ENSLAFG00000001145 I
CUX1 Loxodonta africana ENSLAFG00000002555 I
ENSP00000261726 Macaca fascicularis ENSP00000261726 I
ENSP00000353401 Macaca fascicularis ENSP00000353401 I
CUX1 Macaca mulatta ENSMMUG00000021461 I
ENSMEUG00000004239 Macropus eugenii ENSMEUG00000004239 I
CUX1 Meleagris gallopavo ENSMGAG00000003398 I
CUX2 Meleagris gallopavo ENSMGAG00000005225 I
CUX1 Microcebus murinus ENSMICG00000010274 I
CUX2 Monodelphis domestica ENSMODG00000012254 I
CUX1 Monodelphis domestica ENSMODG00000013581 I
ENSMPUG00000002207 Mustela putorius furo ENSMPUG00000002207 I
Cux1 Mus musculus ENSMUSG00000029705 D
Cux2 Mus musculus ENSMUSG00000042589 D
Myotis_brandtii_CUX1_10015212 Myotis brandtii Myotis_brandtii_CUX1_10015212 I
Myotis_brandtii_CUX2_10011523 Myotis brandtii Myotis_brandtii_CUX2_10011523 I
CUX2 Myotis lucifugus ENSMLUG00000003239 I
CUX1 Myotis lucifugus ENSMLUG00000007264 I
ENSNLEG00000000470 Nomascus leucogenys ENSNLEG00000000470 I
ENSNLEG00000008310 Nomascus leucogenys ENSNLEG00000008310 I
CUX1 Ochotona princeps ENSOPRG00000000165 I
CUX2 Ochotona princeps ENSOPRG00000006461 I
Ogr05066 Ophisaurus gracilis Ogr05066 I
Ogr05872 Ophisaurus gracilis Ogr05872 I
ENSONIG00000003797 Oreochromis niloticus ENSONIG00000003797 I
ENSONIG00000015972 Oreochromis niloticus ENSONIG00000015972 I
CUX2 Ornithorhynchus anatinus ENSOANG00000004793 I
CUX2 Oryctolagus cuniculus ENSOCUG00000021923 I
cux2b Oryzias latipes ENSORLG00000015973 I
ENSOGAG00000009038 Otolemur garnettii ENSOGAG00000009038 I
CUX2 Otolemur garnettii ENSOGAG00000029919 I
ENSOARG00000014629 Ovis aries ENSOARG00000014629 I
ENSOARG00000017879 Ovis aries ENSOARG00000017879 I
CUX2 Pan troglodytes ENSPTRG00000005455 I
CUX1 Pan troglodytes ENSPTRG00000019531 I
ENSPANG00000016879 Papio anubis ENSPANG00000016879 I
ENSPSIG00000008210 Pelodiscus sinensis ENSPSIG00000008210 I
ENSPFOG00000005210 Poecilia formosa ENSPFOG00000005210 I
Pvit_01819 Pogona vitticeps Pvit_01819 I
Pvit_05599 Pogona vitticeps Pvit_05599 I
CUX2 Pteropus vampyrus ENSPVAG00000013176 I
CUX1 Pteropus vampyrus ENSPVAG00000017756 I
Cux2 Rattus norvegicus ENSRNOG00000001259 I
Cux1 Rattus norvegicus ENSRNOG00000001424 I
ENSSHAG00000007801 Sarcophilus harrisii ENSSHAG00000007801 I
ENSSHAG00000009458 Sarcophilus harrisii ENSSHAG00000009458 I
CUX2 Sus scrofa ENSSSCG00000009831 I
ENSSSCG00000021013 Sus scrofa ENSSSCG00000021013 I
CUX1 Taeniopygia guttata ENSTGUG00000004386 I
CUX2 Taeniopygia guttata ENSTGUG00000006470 I
CUX1 Takifugu rubripes ENSTRUG00000008546 I
cux2b Takifugu rubripes ENSTRUG00000015853 I
ENSTNIG00000007722 Tetraodon nigroviridis ENSTNIG00000007722 I
cux2b Tetraodon nigroviridis ENSTNIG00000011453 I
CUX2 Tursiops truncatus ENSTTRG00000000945 I
CUX1 Tursiops truncatus ENSTTRG00000014625 I
Tal_R013483 Tyto alba Tal_R013483 I
cux2 Xenopus tropicalis XB-GENE-487236 I
XP_002942311 Xenopus tropicalis XP_002942311 I
ENSXMAG00000004131 Xiphophorus maculatus ENSXMAG00000004131 I
ENSXMAG00000018520 Xiphophorus maculatus ENSXMAG00000018520 I