LEU3 (Saccharomyces cerevisiae)
Zinc cluster

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00172 (Zn_clus) IPR001138 YLR451W T388367_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of leucine biosynthetic process; and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
LEU3
M01590_2.00		 Saccharomyces cerevisiae
NNCGGNNNN
NNNNCCGNN		 PBM
Zhu et al.(2009)
Leu3		 (Direct) (Direct)
LEU3
M07526_2.00		 Saccharomyces cerevisiae
CCKDHDSCGS
SCGSHDHMGG		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0324.1		 (Direct) (Direct)
LEU3
M08684_2.00		 Saccharomyces cerevisiae
SCKNNNNMGS
SCKNNNNMGS		 Misc
DeBoer et al.(2011)
YLR451W_781		 (Direct) (Direct)
LEU3
M11482_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$LEU3_B		 (Direct) (Direct)
LEU3
M11483_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$LEU3_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.537 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01590_2.00 Zinc cluster 35 77

DNA Binding Domains

Protein ID Domain From To Sequence
YLR451W Zinc cluster 35 77

Links

Other Zinc cluster family TFs
Other Saccharomyces cerevisiae TFs

Invalid Input OrderBy

46 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action