CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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POU5F1B
(
Homo sapiens
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSG00000212993
T209944_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
POU5F1B
M01509_2.00
Homo sapiens
HHWBYRN
NYRVWDD
PBM
Yin et al.(2017b)
POU5F1_5mCG
(Direct)
(Direct)
POU5F1B
M01510_2.00
Homo sapiens
NHWWBND
HNVWWDN
PBM
Yin et al.(2017b)
POU5F1_Cytosine
(Direct)
(Direct)
POU5F1B
M03239_2.00
Homo sapiens
TATGYWAAT
ATTWRCATA
SELEX
Jolma et al.(2013)
POU5F1P1_1
(Direct)
(Direct)
POU5F1B
M03240_2.00
Homo sapiens
WTGMATATKCAW
WTGMATATKCAW
SELEX
Jolma et al.(2013)
POU5F1P1_2
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M01509_2.00
POU
19
90
ALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD
M01509_2.00
Homeodomain
109
164
KRKRTSIENRVRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVWFCNRRQKGKR
M01510_2.00
POU
19
90
ALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD
M01510_2.00
Homeodomain
109
164
KRKRTSIENRVRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVWFCNRRQKGKR
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000419298
Homeodomain
231
286
KRKRTSIENRVRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVWFCNRRQKGKR
Links
Other
Homeodomain
family TFs
Other
Homo sapiens
TFs
0 Related TFs
">No related TF found