POU2F2 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSG00000028277 T238188_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU2F2
M02742_2.00		 Homo sapiens
TGAATATTCA
TGAATATTCA		 SELEX
Jolma et al.(2010)
POU2F2_monomer		 (Direct) (Direct)
POU2F2
M02743_2.00		 Homo sapiens
TATKCAMATH
DATKTGMATA		 SELEX
Jolma et al.(2010)
POU2F2_secondary_motif		 (Direct) (Direct)
POU2F2
M03298_2.00		 Homo sapiens
DTATGYWAATN
NATTWRCATAH		 SELEX
Jolma et al.(2013)
POU2F2_1		 (Direct) (Direct)
POU2F2
M03299_2.00		 Homo sapiens
HHTRMATATKCAHN
NDTGMATATKYADD		 SELEX
Jolma et al.(2013)
POU2F2_2		 (Direct) (Direct)
POU2F2
M05444_2.00		 Homo sapiens
DVRTTWBSNWAAYBN
NVRTTWNSVWAAYBH		 SELEX
Yin et al.(2017)
POU2F2_eDBD_HT-SELEX_1		 (Direct) (Direct)
POU2F2
M05445_2.00		 Homo sapiens
NTWAYKHATGCD
HGCATDMRTWAN		 SELEX
Yin et al.(2017)
POU2F2_eDBD_HT-SELEX_2		 (Direct) (Direct)
POU2F2
M05446_2.00		 Homo sapiens
NYATGCWAATN
NATTWGCATRN		 SELEX
Yin et al.(2017)
POU2F2_eDBD_HT-SELEX_3		 (Direct) (Direct)
POU2F2
M05447_2.00		 Homo sapiens
DTRMATATKYAD
HTRMATATKYAH		 SELEX
Yin et al.(2017)
POU2F2_eDBD_HT-SELEX_4		 (Direct) (Direct)
POU2F2
M05448_2.00		 Homo sapiens
NNGCVTAWTBNN
NNVAWTABGCNN		 SELEX
Yin et al.(2017)
POU2F2_eDBD_HT-SELEX_5		 (Direct) (Direct)
POU2F2
M05449_2.00		 Homo sapiens
DTATGCWAATK
MATTWGCATAH		 SELEX
Yin et al.(2017)
POU2F2_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU2F2
M05450_2.00		 Homo sapiens
WWGCATAATBHN
NDVATTATGCWW		 SELEX
Yin et al.(2017)
POU2F2_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
POU2F2
M05451_2.00		 Homo sapiens
WWRMATATKYWW
WWRMATATKYWW		 SELEX
Yin et al.(2017)
POU2F2_eDBD_Methyl-HT-SELEX_3		 (Direct) (Direct)
POU2F2
M05452_2.00		 Homo sapiens
DTATGCGCATAH
DTATGCGCATAH		 SELEX
Yin et al.(2017)
POU2F2_eDBD_Methyl-HT-SELEX_4		 (Direct) (Direct)
POU2F2
M07972_2.00		 Homo sapiens
NYATGCAAAT
ATTTGCATRN		 ChIP-seq
Gerstein et al.(2012)
GM12878_OCT2_HudsonAlpha		 (Direct) (Direct)
POU2F2
M07973_2.00		 Homo sapiens
NYATGCAAAT
ATTTGCATRN		 ChIP-seq
Gerstein et al.(2012)
GM12878_POU2F2_HudsonAlpha		 (Direct) (Direct)
POU2F2
M07974_2.00		 Homo sapiens
NYATGCAAATNNN
NNNATTTGCATRN		 ChIP-seq
Gerstein et al.(2012)
GM12891_OCT2_HudsonAlpha		 (Direct) (Direct)
POU2F2
M07975_2.00		 Homo sapiens
NYATGCAAATNNN
NNNATTTGCATRN		 ChIP-seq
Gerstein et al.(2012)
GM12891_POU2F2_HudsonAlpha		 (Direct) (Direct)
POU2F2
M08140_2.00		 Homo sapiens
DHATGCAAATNHN
NDNATTTGCATDH		 ChIP-seq
Mathelier et al.(2014)
MA0507.1		 (Direct) (Direct)
POU2F2
M09218_2.00		 Homo sapiens
NYATGCAWATN
NATWTGCATRN		 Misc
Kulakovskiy et al.(2013)
PO2F2_HUMAN.H11MO.0.A		 (Direct) (Direct)
POU2F2
M10819_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$OCT2_Q6		 (Direct) (Direct)
POU2F2
M10820_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU2F2_06		 (Direct) (Direct)
POU2F2
M10821_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU2F2_09		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pou2f1
M00803_2.00 		Mus musculus
NHATWWNHNN
NNDNWWATDN		 PBM
Weirauch et al.(2013)
pTH4325 		0.958 0.958
Pou2f2
M00544_2.00 		Mus musculus
NNNATTAN
NTAATNNN		 PBM
Berger et al.(2008)
Pou2f2_3748 		1.000 1.000
Pou1f1
M02238_2.00 		Mus musculus
NTAATKHNN
NNDMATTAN		 PBM
Weirauch et al.(2014)
pTH6507 		0.678 0.579
acj6
M02241_2.00 		Drosophila melanogaster
VTMATTAA
TTAATKAB		 PBM
Weirauch et al.(2014)
pTH6053 		0.654 0.491
POU6F1
M02094_2.00 		Homo sapiens
VNTAATTANB
VNTAATTANB		 PBM
Weirauch et al.(2014)
pTH6519 		0.621 0.491
pdm3
M02127_2.00 		Drosophila melanogaster
CTAATTAN
NTAATTAG		 PBM
Weirauch et al.(2014)
pTH6769 		0.600 0.456
Pou2f2
M03322_2.00 		Mus musculus
HWTGMATATKCAWR
YWTGMATATKCAWD		 SELEX
Jolma et al.(2013)
Pou2f2_1 		1.000 1.000
Pou2f2
M03323_2.00 		Mus musculus
TATGCAAAT
ATTTGCATA		 SELEX
Jolma et al.(2013)
Pou2f2_2 		1.000 1.000
Pou2f2
M09224_2.00 		Mus musculus
NYATGCAWATN
NATWTGCATRN		 Misc
Kulakovskiy et al.(2013)
PO2F2_MOUSE.H11MO.0.B 		1.000 1.000
Pou2f2
M09589_2.00 		Mus musculus
ATATGCAAAT
ATTTGCATAT		 Misc
Heinz et al.(2010)
Bcell-Oct2_GSE21512 		1.000 1.000
For this family, TFs with SR scores > 0.993 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000339369 POU 182 253
ENSP00000339369 Homeodomain 282 338
ENSP00000373992 POU 182 253
ENSP00000373992 Homeodomain 282 338
ENSP00000431603 POU 198 269
ENSP00000431603 Homeodomain 298 354
ENSP00000436988 POU 198 269
ENSP00000436988 Homeodomain 298 354
ENSP00000437224 POU 182 253
ENSP00000437224 Homeodomain 282 338
ENSP00000452930 POU 200 271
ENSP00000452930 Homeodomain 300 356
ENSP00000453255 POU 204 275
ENSP00000453255 Homeodomain 304 360
ENSP00000454179 POU 143 214
ENSP00000454179 Homeodomain 243 299
ENSP00000471890 Homeodomain 3 59
ENSP00000475664 POU 192 262
ENSP00000476062 POU 157 220

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

91 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
POU2F2 Gorilla gorilla ENSGGOG00000011088 I 1.000
POU2F2 Loxodonta africana ENSLAFG00000009508 I 1.000
ENSMEUG00000016676 Macropus eugenii ENSMEUG00000016676 I 1.000
POU2F2 Microcebus murinus ENSMICG00000015156 I 1.000
POU2F2 Echinops telfairi ENSETEG00000009259 I 1.000
POU2F2 Equus caballus ENSECAG00000004906 I 1.000
ENSCHOG00000005106 Choloepus hoffmanni ENSCHOG00000005106 I 1.000
POU2F2 Canis familiaris ENSCAFG00000004911 I 1.000
POU2F2 Callithrix jacchus ENSCJAG00000012753 I 1.000
ENSCSAG00000003479 Chlorocebus sabaeus ENSCSAG00000003479 I 1.000
ENSDNOG00000046180 Dasypus novemcinctus ENSDNOG00000046180 I 1.000
POU2F2 Macaca mulatta ENSMMUG00000013376 I 1.000
Pou2f2 Mus musculus ENSMUSG00000008496 D 1.000
ENSBTAP00000011279-D1 Bos grunniens ENSBTAP00000011279-D1 I 1.000
POU2F2 Tursiops truncatus ENSTTRG00000008331 I 1.000
ENSMMUP00000031584 Macaca fascicularis ENSMMUP00000031584 I 1.000
Myotis_brandtii_POU2F2_10007123 Myotis brandtii Myotis_brandtii_POU2F2_10007123 I 1.000
POU2F2 Pteropus vampyrus ENSPVAG00000010621 I 1.000
ENSSTOG00000021390 Ictidomys tridecemlineatus ENSSTOG00000021390 I 1.000
ENSSHAG00000009106 Sarcophilus harrisii ENSSHAG00000009106 I 1.000
POU2F2 Procavia capensis ENSPCAG00000008356 I 1.000
ENSPANG00000008094 Papio anubis ENSPANG00000008094 I 1.000
ENSPPYG00000010036 Pongo abelii ENSPPYG00000010036 I 1.000
POU2F2 Pan troglodytes ENSPTRG00000011045 I 1.000
Pou2f2 Rattus norvegicus ENSRNOG00000055650 I 1.000
ENSAMEG00000004811 Ailuropoda melanoleuca ENSAMEG00000004811 I 1.000
POU2F2 Oryctolagus cuniculus ENSOCUG00000021776 I 1.000
CAA36119 Xenopus laevis CAA36119 I 0.974
ENSTSYG00000009143 Tarsius syrichta ENSTSYG00000009143 I 0.972
ENSPPYG00000003972 Pongo abelii ENSPPYG00000003972 I 0.972
POU2F3 Pan troglodytes ENSPTRG00000004391 I 0.972
AMAM009299 Anopheles maculatus AMAM009299 I 0.962
ENSSARG00000008273 Sorex araneus ENSSARG00000008273 I 0.958
ENSGMOG00000000005 Gadus morhua ENSGMOG00000000005 I 0.944
ENSORLG00000014257 Oryzias latipes ENSORLG00000014257 I 0.944
ENSVPAG00000010276 Vicugna pacos ENSVPAG00000010276 I 0.941
ENSSHAG00000018562 Sarcophilus harrisii ENSSHAG00000018562 I 0.847
AMAM009961 Anopheles maculatus AMAM009961 I 0.837
MESCA009897 Megaselia scalaris MESCA009897 I 0.826
GPUH_0002653201 Gongylonema pulchrum GPUH_0002653201 I 0.812
ENSCSAVG00000007148 Ciona savignyi ENSCSAVG00000007148 I 0.811
SBAD_0000845701 Soboliphyme baturini SBAD_0000845701 I 0.806
L898_g22690 Steinernema monticolum L898_g22690 I 0.797
L892_g6561 Steinernema scapterisci L892_g6561 I 0.797
L889_g16900 Steinernema feltiae L889_g16900 I 0.797
L596_g16531 Steinernema carpocapsae L596_g16531 I 0.797
L893_g4672 Steinernema glaseri L893_g4672 I 0.797
BGIBMGA010300 Bombyx mori BGIBMGA010300 I 0.795
ENSCING00000013609 Ciona intestinalis ENSCING00000013609 I 0.795
TTRE_0000958901 Trichuris trichiura TTRE_0000958901 I 0.781
D918_02683 Trichuris suis D918_02683 I 0.775
Pou3f3 Mus musculus ENSMUSG00000045515 D 0.764
pou3f3b Oryzias latipes ENSORLG00000001901 I 0.764
ENSDORG00000005303 Dipodomys ordii ENSDORG00000005303 I 0.764
ENSMLUG00000001011 Myotis lucifugus ENSMLUG00000001011 I 0.761
ceh-18 Caenorhabditis elegans WBGene00000441 D 0.761
TELCIR_24859 Teladorsagia circumcincta TELCIR_24859 I 0.757
OESDEN_22180 Oesophagostomum dentatum OESDEN_22180 I 0.757
pou5f3 Tetraodon nigroviridis ENSTNIG00000003465 I 0.750
GPUH_0000960301 Gongylonema pulchrum GPUH_0000960301 I 0.750
HelroG138303 Helobdella robusta HelroG138303 I 0.746
Sjc_0006200 Schistosoma japonicum Sjc_0006200 I 0.746
BXY_0883500 Bursaphelenchus xylophilus BXY_0883500 I 0.746
SBAD_0000673901 Soboliphyme baturini SBAD_0000673901 I 0.740
CGOC_0000363501 Cylicostephanus goldi CGOC_0000363501 N 0.734
ENSXMAG00000019380 Xiphophorus maculatus ENSXMAG00000019380 I 0.732
ENSOANG00000013329 Ornithorhynchus anatinus ENSOANG00000013329 I 0.728
pou2f1b Danio rerio ENSDARG00000007996 I 0.719
snap_masked-nMf.1.1.scaf03688-processed-gene-0.4 Meloidogyne floridensis snap_masked-nMf.1.1.scaf03688-processed-gene-0.4 N 0.719
Brh_R009827 Buceros rhinoceros Brh_R009827 I 0.703
AMAM021613 Anopheles maculatus AMAM021613 I 0.686
L596_g13343 Steinernema carpocapsae L596_g13343 I 0.672
GPUH_0000951201 Gongylonema pulchrum GPUH_0000951201 I 0.671
EFV49290 Trichinella spiralis EFV49290 I 0.666
Cmyd_10006628 Chelonia mydas Cmyd_10006628 I 0.663
Ogr05710 Ophisaurus gracilis Ogr05710 I 0.663
L798_02028 Zootermopsis nevadensis L798_02028 I 0.654
L898_g18190 Steinernema monticolum L898_g18190 I 0.654
Cflo_05860--XP_394134.2_APIME Camponotus floridanus Cflo_05860--XP_394134.2_APIME I 0.654
DAPPUDRAFT_9350 Daphnia pulex DAPPUDRAFT_9350 I 0.654
PPAI004106 Phlebotomus papatasi PPAI004106 I 0.654
acj6 Drosophila melanogaster FBgn0000028 D 0.654
DAPPUDRAFT_9412 Daphnia pulex DAPPUDRAFT_9412 N 0.653
POU5F1 Callithrix jacchus ENSCJAG00000019789 I 0.641
POU6F1 Homo sapiens ENSG00000184271 D 0.621
pdm3 Drosophila melanogaster FBgn0261588 D 0.600
BGIBMGA005254 Bombyx mori BGIBMGA005254 I 0.600
CpipJ_CPIJ003414 Culex pipiens CpipJ_CPIJ003414 I 0.600
ACUA020432 Anopheles culicifacies ACUA020432 I 0.600
CPIJ003414 Culex quinquefasciatus CPIJ003414 I 0.600