POU2F3 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSG00000137709 T238192_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU2F3
M03306_2.00		 Homo sapiens
TATGYWAAT
ATTWRCATA		 SELEX
Jolma et al.(2013)
POU2F3_1		 (Direct) (Direct)
POU2F3
M03307_2.00		 Homo sapiens
WTRMATAWKYAW
WTRMWTATKYAW		 SELEX
Jolma et al.(2013)
POU2F3_2		 (Direct) (Direct)
POU2F3
M05467_2.00		 Homo sapiens
BNAYGCTDAYS
SRTHAGCRTNV		 SELEX
Yin et al.(2017)
POU2F3_eDBD_HT-SELEX		 (Direct) (Direct)
POU2F3
M05468_2.00		 Homo sapiens
NYATGYWAATN
NATTWRCATRN		 SELEX
Yin et al.(2017)
POU2F3_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU2F3
M05469_2.00		 Homo sapiens
NNATRCGMATRH
DYATKCGYATNN		 SELEX
Yin et al.(2017)
POU2F3_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pou2f1
M00803_2.00 		Mus musculus
NHATWWNHNN
NNDNWWATDN		 PBM
Weirauch et al.(2013)
pTH4325 		0.979 0.979
For this family, TFs with SR scores > 0.993 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000260264 POU 188 259
ENSP00000260264 Homeodomain 284 340
ENSP00000441687 POU 186 257
ENSP00000441687 Homeodomain 282 338
ENSP00000453150 POU 1 48

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

21 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
POU2F3 Bos taurus ENSBTAG00000021340 I 1.000
ENSNLEG00000007403 Nomascus leucogenys ENSNLEG00000007403 I 1.000
ENSPANG00000005039 Papio anubis ENSPANG00000005039 I 1.000
ENSSTOG00000015839 Ictidomys tridecemlineatus ENSSTOG00000015839 I 1.000
ENSP00000260264 Macaca fascicularis ENSP00000260264 I 1.000
ENSP00000260264-D1 Bos grunniens ENSP00000260264-D1 I 1.000
POU2F3 Macaca mulatta ENSMMUG00000012251 I 1.000
ENSOARG00000016819 Ovis aries ENSOARG00000016819 I 1.000
POU2F3 Cavia porcellus ENSCPOG00000010476 I 1.000
POU2F3 Loxodonta africana ENSLAFG00000007476 I 1.000
ENSCSAG00000002476 Chlorocebus sabaeus ENSCSAG00000002476 I 1.000
POU2F3 Callithrix jacchus ENSCJAG00000014166 I 1.000
POU2F3 Gorilla gorilla ENSGGOG00000008715 I 1.000
POU2F3 Equus caballus ENSECAG00000019818 I 1.000
ENSXMAG00000019380 Xiphophorus maculatus ENSXMAG00000019380 I 0.979
GPUH_0002653201 Gongylonema pulchrum GPUH_0002653201 I 0.833
pou5f3 Tetraodon nigroviridis ENSTNIG00000003465 I 0.812
SNAPOd2T00011770001 Oikopleura dioica SNAPOd2T00011770001 I 0.800
maker-nMf.1.1.scaf02834-augustus-gene-0.10 Meloidogyne floridensis maker-nMf.1.1.scaf02834-augustus-gene-0.10 I 0.771
snap_masked-nMf.1.1.scaf03688-processed-gene-0.4 Meloidogyne floridensis snap_masked-nMf.1.1.scaf03688-processed-gene-0.4 N 0.750