unc-86 (Caenorhabditis elegans)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		WBGene00006818 T238867_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mechanosensory behavior; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15 and autosomal dominant nonsyndromic deafness 52. Orthologous to several human genes including POU4F2 (POU class 4 homeobox 2) and POU4F3 (POU class 4 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
unc-86
M02244_2.00		 Caenorhabditis elegans
ATGCATAH
DTATGCAT		 PBM
Weirauch et al.(2014)
pTH8341		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.993 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02244_2.00 POU 54 128
M02244_2.00 Homeodomain 150 206

DNA Binding Domains

Protein ID Domain From To Sequence
C30A5.7a POU 120 194
C30A5.7a Homeodomain 216 272
C30A5.7b POU 158 232
C30A5.7b Homeodomain 254 310

Links

Other Homeodomain,POU family TFs
Other Caenorhabditis elegans TFs

4 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE25126 Caenorhabditis remanei CRE25126 I 1.000
CBN19903 Caenorhabditis brenneri CBN19903 I 1.000
CBG16662 Caenorhabditis briggsae CBG16662 I 1.000