CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Ovol2
(
Mus musculus
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSMUSG00000037279
T101139_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; regulation of SMAD protein signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Ovol2
M08993_2.00
Mus musculus
HCCGTTAN
NTAACGGD
Misc
Kulakovskiy et al.(2013)
OVOL2_MOUSE.H11MO.0.C
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
OVOL2
M00235_2.00
Homo sapiens
NCCGYTANNN
NNNTARCGGN
PBM
Barrera et al.(2016)
OVOL2_REF
0.813
0.967
OVOL2
M04445_2.00
Homo sapiens
NNHCCGYTANNHN
NDNNTARCGGDNN
SELEX
Yin et al.(2017)
OVOL2_eDBD_HT-SELEX
0.813
0.967
OVOL2
M04447_2.00
Homo sapiens
DDWCCGTTABNHN
NDNVTAACGGWHH
SELEX
Yin et al.(2017)
OVOL2_FL_HT-SELEX
0.813
0.967
OVOL2
M10207_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MOVOB_01
0.813
0.967
OVOL2
M04446_2.00
Homo sapiens
NNWCCGTTANNHN
NDNNTAACGGWNN
SELEX
Yin et al.(2017)
OVOL2_eDBD_Methyl-HT-SELEX
0.813
0.967
OVOL2
M04448_2.00
Homo sapiens
DDWCCGTTABNHN
NDNVTAACGGWHH
SELEX
Yin et al.(2017)
OVOL2_FL_Methyl-HT-SELEX
0.813
0.967
OVOL2
M00234_2.00
Homo sapiens
NCCGYTANNN
NNNTARCGGN
PBM
Barrera et al.(2016)
OVOL2_D228E
0.758
0.957
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000044026
C2H2 ZF
118
140
HNCDLCGKSFRLQRMLNRHLKCH
ENSMUSP00000044026
C2H2 ZF
146
168
HLCTFCGKGFNDTFDLKRHVRTH
ENSMUSP00000044026
C2H2 ZF
174
197
YKCEVCNKAFTQRCSLESHLKKIH
ENSMUSP00000044026
C2H2 ZF
213
236
YVCEDCGYTGPTQEDLYLHVNSDH
ENSMUSP00000099460
C2H2 ZF
85
107
HNCDLCGKSFRLQRMLNRHLKCH
ENSMUSP00000099460
C2H2 ZF
113
135
HLCTFCGKGFNDTFDLKRHVRTH
ENSMUSP00000099460
C2H2 ZF
141
164
YKCEVCNKAFTQRCSLESHLKKIH
ENSMUSP00000099460
C2H2 ZF
180
203
YVCEDCGYTGPTQEDLYLHVNSDH
Links
Other
C2H2 ZF
family TFs
Other
Mus musculus
TFs
53 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy