MAFK (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000198517 T025323_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
MAFK
M2296_1.02
Homo sapiens
HHNWVTCAGCANWWH

DWWNTGCTGABWNDD
ChIP-seq
Mathelier et al.(2014)
MA0496.1
(Direct)
MAFK
M3534_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MAFK_07
(Direct)
MAFK
M3535_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MAFK_Q3
(Direct)
MAFK
M4573_1.02
Homo sapiens
TGCTGASTYAKSH

DSMTRASTCAGCA
ChIP-seq
Gerstein et al.(2012)
HepG2_MAFK_Stanford
(Direct)
MAFK
M4626_1.02
Homo sapiens
SMTGASTCAGCANWW

WWNTGCTGASTCAKS
ChIP-seq
Gerstein et al.(2012)
K562_MAFK_Stanford
(Direct)
MAFK
M5609_1.02
Homo sapiens
NDWWNTGCTGAB

VTCAGCANWWHN
SELEX
Jolma et al.(2013)
MAFK_1
(Direct)
MAFK
M5610_1.02
Homo sapiens
NDNNYGCTKAVTCAGCRNNH

NDNNYGCTGABTMAGCRNNH
SELEX
Jolma et al.(2013)
MAFK_2
(Direct)
MAFK
M5611_1.02
Homo sapiens
NDWWDTGCTGAS

STCAGCAHWWHN
SELEX
Jolma et al.(2013)
MAFK_3
(Direct)
MAFK
M5612_1.02
Homo sapiens
DTGCTGANTCAGCRN

NYGCTGANTCAGCAH
SELEX
Jolma et al.(2013)
MAFK_4
(Direct)
MAFK
M6334_1.02
Homo sapiens
TGACTCAGCR

YGCTGAGTCA
HocoMoco
Kulakovskiy et al.(2013)
MAFK_si
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
Mafk
M0290_1.02
Mus musculus
NNHNYKHNNN

NNNDMRNDNN
PBM
Badis et al.(2009)
Mafk_3106
0.972
MAFG
M6333_1.02
Homo sapiens
NATGACD

HGTCATN
HocoMoco
Kulakovskiy et al.(2013)
MAFG_si
0.855
MAFG
M5608_1.02
Homo sapiens
DWWNTGCTGASTCAGCRNDW

DWHNYGCTGASTCAGCANWW
SELEX
Jolma et al.(2013)
MAFG_1
0.855
MAFG
M3533_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MAFG_Q3
0.855
Mafg
M0308_1.02
Mus musculus
NWHDKCDNNN

NNNHGMHDWN
PBM
Weirauch et al.(2014)
pTH5098
0.841
MAFF
M2295_1.02
Homo sapiens
BHHDWVTCAGCANWWWNN

NNWWWNTGCTGABWHDDV
ChIP-seq
Mathelier et al.(2014)
MA0495.1
0.768
MAFF
M5607_1.02
Homo sapiens
NTGCTGASTCAGCAW

WTGCTGASTCAGCAN
SELEX
Jolma et al.(2013)
MAFF_1
0.768
MAFF
M4572_1.02
Homo sapiens
TGCTGASTCAGCANW

WNTGCTGASTCAGCA
ChIP-seq
Gerstein et al.(2012)
HepG2_MAFF_Stanford
0.768
MAFF
M3532_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MAFF_04
0.768
MAFF
M3530_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MAFF_02
0.768
For this family, TFs with SR scores > 0.550 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000344903 bZIP 49 117
ENSP00000385437 bZIP 49 117
ENSP00000386009 bZIP 49 117

Links

Other bZIP family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found