SP2 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000167182 T044474_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
SP2
M2314_1.02
Homo sapiens
VNNVRGRGGCGGGRV

BYCCCGCCYCYBNNB
ChIP-seq
Mathelier et al.(2014)
MA0516.1
(Direct)
SP2
M3927_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_01
(Direct)
SP2
M3928_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_02
(Direct)
SP2
M3929_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_03
(Direct)
SP2
M3930_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_04
(Direct)
SP2
M3931_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_06
(Direct)
SP2
M3932_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_Q3_01
(Direct)
SP2
M3933_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_Q3
(Direct)
SP2
M4632_1.02
Homo sapiens
KSCTAGAGMGGCBVB

VBVGCCKCTCTAGSM
ChIP-seq
Gerstein et al.(2012)
K562_SP2_HudsonAlpha
(Direct)
SP2
M6481_1.02
Homo sapiens
NDDKRRGGSGGRRNBRN

NYVNYYCCSCCYYMHHN
HocoMoco
Kulakovskiy et al.(2013)
SP2_si
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
Sp4
M0402_1.02
Mus musculus
NRKGGGCGKD

HMCGCCCMYN
PBM
Badis et al.(2009)
Sp4_1011
0.781
Sp4
M0401_1.02
Mus musculus
RKGGGCGKN

NMCGCCCMY
PBM
Weirauch et al.(2014)
pTH4998
0.781
SP3
M6482_1.02
Homo sapiens
NNVVVKGGGMGGGGSBNVVN

NBBNVSCCCCKCCCMBBBNN
HocoMoco
Kulakovskiy et al.(2013)
SP3_f1
0.767
SP8
M5856_1.02
Homo sapiens
DGKGGGVGTGKB

VMCACBCCCMCH
SELEX
Jolma et al.(2013)
SP8_1
0.767
SP4
M5855_1.02
Homo sapiens
NRDGKGGGCGTGGCYWN

NWRGCCACGCCCMCHYN
SELEX
Jolma et al.(2013)
SP4_1
0.767
SP3
M5854_1.02
Homo sapiens
RKGGGYGKGGB

VCCMCRCCCMY
SELEX
Jolma et al.(2013)
SP3_1
0.767
Sp1
M5210_1.02
Drosophila melanogaster
NNRKGGGCGKDDMN

NKHHMCGCCCMYNN
B1H
Zhu et al.(2011)
Sp1_SOLEXA_2.5_FBgn0020378
0.767
Sp1
M5209_1.02
Drosophila melanogaster
RKGGGCGKRDH

DHYMCGCCCMY
B1H
Zhu et al.(2011)
Sp1_SANGER_5_FBgn0020378
0.767
SP4
M3935_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP4_Q5
0.767
SP3
M3934_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP3_Q3
0.767
SP4
M6483_1.02
Homo sapiens
VSDNSSRBGGGSGGSGSGSV

BSNSBSCSCSCCSCCCVYSS
HocoMoco
Kulakovskiy et al.(2013)
SP4_f1
0.767
Sp1
M0392_1.02
Mus musculus
RKGGGCGKN

NMCGCCCMY
PBM
Weirauch et al.(2013)
pTH0978
0.740
SP1
M6480_1.02
Homo sapiens
VNVVNRGGGGMGGGGVBNV

BNVBCCCCKCCCCYNBBNB
HocoMoco
Kulakovskiy et al.(2013)
SP1_f2
0.726
SP1
M3921_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP1_06
0.726
SP1
M6479_1.02
Homo sapiens
RGGGGMGGGGN

NCCCCKCCCCY
HocoMoco
Kulakovskiy et al.(2013)
SP1_f1
0.726
SP1
M3920_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP1_02
0.726
SP1
M5853_1.02
Homo sapiens
DKGGGHGKGGY

RCCMCDCCCMH
SELEX
Jolma et al.(2013)
SP1_1
0.726
SP1
M3919_1.02
Homo sapiens
DRGGCDKGSH

DSCMHGCCYH
Transfac
Matys et al.(2006)
V$SP1_01
0.726
CG5669
M4871_1.02
Drosophila melanogaster
NRKGGGCGKGGCHHV

BDDGCCMCGCCCMYN
B1H
Zhu et al.(2011)
CG5669_SOLEXA_5_FBgn0039169
0.726
SP1
M1906_1.02
Homo sapiens
RGGGGMGGGRV

BYCCCKCCCCY
ChIP-seq
Mathelier et al.(2014)
MA0079.3
0.726
CG5669
M4870_1.02
Drosophila melanogaster
DVKGGGCGKGGYHWM

KWDRCCMCGCCCMBH
B1H
Zhu et al.(2011)
CG5669_SANGER_10_FBgn0039169
0.726
SP1
M3926_1.02
Homo sapiens
NVKGGGCGGGGBB

VVCCCCGCCCMBN
Transfac
Matys et al.(2006)
V$SP1_Q6
0.726
SP1
M3925_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP1_Q6_02
0.726
SP1
M3924_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP1_Q3
0.726
SP1
M3923_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP1_08
0.726
SP1
M3922_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP1_07
0.726
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000365931 C2H2 ZF 525 549
ENSP00000365931 C2H2 ZF 555 579
ENSP00000365931 C2H2 ZF 585 607

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found