ETV1 (Homo sapiens)
Ets

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00178 (Ets) IPR000418 ENSG00000006468 T077979_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
ETV1
M5420_1.02
Homo sapiens
RCCGGAWRYN

NRYWTCCGGY
SELEX
Jolma et al.(2013)
ETV1_1
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
Gm5454
M0710_1.02
Mus musculus
NDCCGGAWRY

RYWTCCGGHN
PBM
Wei et al.(2010)
Gm5454
1.000
Etv1
M0690_1.02
Mus musculus
NNSCGGAWVH

DBWTCCGSNN
PBM
Wei et al.(2010)
Etv1
1.000
ETV5
M6223_1.02
Homo sapiens
VHSMGGADGDWAY

RTWHCHTCCKSDB
HocoMoco
Kulakovskiy et al.(2013)
ETV5_f1
0.964
ETV5
M5424_1.02
Homo sapiens
DVCGGAWRYN

NRYWTCCGBH
SELEX
Jolma et al.(2013)
ETV5_1
0.964
Etv5
M0698_1.02
Mus musculus
DSCGGAWRY

RYWTCCGSH
PBM
Wei et al.(2010)
Etv5
0.964
ETV4
M5423_1.02
Homo sapiens
DCCGGAWRYN

NRYWTCCGGH
SELEX
Jolma et al.(2013)
ETV4_1
0.940
ETV4
M3743_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PEA3_Q6
0.940
ETV4
M3742_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PEA3_Q6_02
0.940
Etv4
M0700_1.02
Mus musculus
NDSCGGAWRY

RYWTCCGSHN
PBM
Wei et al.(2010)
Etv4
0.940
ETV4
M6222_1.02
Homo sapiens
VMGGAARB

VYTTCCKB
HocoMoco
Kulakovskiy et al.(2013)
ETV4_f1
0.940
Ets96B
M4952_1.02
Drosophila melanogaster
RCCGGAAGYVV

BBRCTTCCGGY
B1H
Zhu et al.(2011)
Ets96B_SANGER_5_FBgn0039225
0.860
ETS1
M4461_1.02
Homo sapiens
GSMYBCTGGGAVWTGTAGTY

RRACTACAWBTCCCAGVRKS
ChIP-seq
Gerstein et al.(2012)
GM12878_ETS1_HudsonAlpha
0.632
ETS1B_CHICK
M3048_1.02
Gallus gallus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CETS168_Q6
0.632
Ets1
M1922_1.02
Mus musculus
NNVRCAGGAAGYDRN

NYHRCTTCCTGYBNN
ChIP-seq
Mathelier et al.(2014)
MA0098.2
0.632
Ets1
M0707_1.02
Mus musculus
NNVMGGAWRH

DYWTCCKBNN
PBM
Wei et al.(2010)
Ets1
0.632
pnt
M5157_1.02
Drosophila melanogaster
ACCGGAART

AYTTCCGGT
B1H
Zhu et al.(2011)
pnt_SANGER_5_FBgn0003118
0.632
ETS1
M4618_1.02
Homo sapiens
CMYBCTGGGAVWTGTAGTYY

NRRACTACAWBTCCCAGVRK
ChIP-seq
Gerstein et al.(2012)
K562_ETS1_HudsonAlpha
0.632
ETS2
M6221_1.02
Homo sapiens
VMVGGAARNDS

SHNYTTCCBKB
HocoMoco
Kulakovskiy et al.(2013)
ETS2_f1
0.621
ETS2
M3224_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ETS2_Q6
0.621
Ets65A
M4951_1.02
Drosophila melanogaster
CCGGAARY

RYTTCCGG
B1H
Zhu et al.(2011)
Ets65A_SANGER_10_FBgn0005658
0.581
Elk4
M0703_1.02
Mus musculus
NNVCGGAWRH

DYWTCCGBNN
PBM
Wei et al.(2010)
Elk4
0.570
ERG
M5402_1.02
Homo sapiens
ACCGGAWATCCGGH

DCCGGATWTCCGGT
SELEX
Jolma et al.(2013)
ERG_4
0.570
ERG
M5401_1.02
Homo sapiens
ACCGGAARYN

NRYTTCCGGT
SELEX
Jolma et al.(2013)
ERG_3
0.570
ERG
M5400_1.02
Homo sapiens
RCCGGAWATCCGSH

DSCGGATWTCCGGY
SELEX
Jolma et al.(2013)
ERG_2
0.570
ERG
M5399_1.02
Homo sapiens
ACCGGAARYN

NRYTTCCGGT
SELEX
Jolma et al.(2013)
ERG_1
0.570
Ets21C
M4950_1.02
Drosophila melanogaster
WCCGGAARY

RYTTCCGGW
B1H
Zhu et al.(2011)
Ets21c_SANGER_5_FBgn0005660
0.570
ERG
M3205_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ERG_01
0.570
Erg
M2276_1.02
Mus musculus
RSAGGAAGYRV

BYRCTTCCTSY
ChIP-seq
Mathelier et al.(2014)
MA0474.1
0.570
FEV
M6226_1.02
Homo sapiens
CMGGAARTDN

NHAYTTCCKG
HocoMoco
Kulakovskiy et al.(2013)
FEV_f1
0.570
Ets21C
M0713_1.02
Drosophila melanogaster
CCGGAARY

RYTTCCGG
PBM
Weirauch et al.(2014)
pTH6450
0.570
ERG
M6213_1.02
Homo sapiens
ACCGGAARTSV

BSAYTTCCGGT
HocoMoco
Kulakovskiy et al.(2013)
ERG_f1
0.570
Erg
M0709_1.02
Mus musculus
NNVMGGAWRN

NYWTCCKBNN
PBM
Wei et al.(2010)
Erg
0.570
FEV
M5429_1.02
Homo sapiens
ACCGGAARTN

NAYTTCCGGT
SELEX
Jolma et al.(2013)
FEV_1
0.570
ELK4
M3859_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SAP1A_Q6
0.558
FLI1
M6227_1.02
Homo sapiens
NVNNVMGGAWGBVVSDH

DHSBBVCWTCCKBNNBN
HocoMoco
Kulakovskiy et al.(2013)
FLI1_f1
0.558
ELK4
M3858_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SAP1A_01
0.558
ELK4
M6209_1.02
Homo sapiens
VACCGGAWGYV

BRCWTCCGGTB
HocoMoco
Kulakovskiy et al.(2013)
ELK4_f1
0.558
FLI1
M3237_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$FLI1_Q6
0.558
FLI1
M5434_1.02
Homo sapiens
RCCGGAWATCCGGH

DCCGGATWTCCGGY
SELEX
Jolma et al.(2013)
FLI1_4
0.558
FLI1
M2277_1.02
Homo sapiens
RCMGGAAGYRR

YYRCTTCCKGY
ChIP-seq
Mathelier et al.(2014)
MA0475.1
0.558
FLI1
M5433_1.02
Homo sapiens
ACCGGAARYN

NRYTTCCGGT
SELEX
Jolma et al.(2013)
FLI1_3
0.558
ELK4
M1903_1.02
Homo sapiens
VCCGGAAGYVV

BBRCTTCCGGB
ChIP-seq
Mathelier et al.(2014)
MA0076.2
0.558
FLI1
M5432_1.02
Homo sapiens
ACCGGAWATCCGSN

NSCGGATWTCCGGT
SELEX
Jolma et al.(2013)
FLI1_2
0.558
Fli1
M0699_1.02
Mus musculus
NNVMGGAWRN

NYWTCCKBNN
PBM
Wei et al.(2010)
Fli1
0.558
FLI1
M5431_1.02
Homo sapiens
RCCGGAWRYN

NRYWTCCGGY
SELEX
Jolma et al.(2013)
FLI1_1
0.558
ELK4
M5385_1.02
Homo sapiens
ACCGGAARYN

NRYTTCCGGT
SELEX
Jolma et al.(2013)
ELK4_1
0.558
ELK4
M4539_1.02
Homo sapiens
NVCCGGAAGYN

NRCTTCCGGBN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_ELK4_UCD
0.558
ELK4
M4522_1.02
Homo sapiens
CCGGAAGYNV

BNRCTTCCGG
ChIP-seq
Gerstein et al.(2012)
HEK293b_ELK4_UCD
0.558
Gabpa
M1891_1.02
Mus musculus
CCGGAAGYVVN

NBBRCTTCCGG
ChIP-seq
Mathelier et al.(2014)
MA0062.2
0.553
GABPA
M4540_1.02
Homo sapiens
VVVCCGGAAGYNVN

NBNRCTTCCGGBBB
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_GABP_HudsonAlpha
0.553
Gabpa
M0694_1.02
Mus musculus
RSCGGAARY

RYTTCCGSY
PBM
Wei et al.(2010)
Gabpa
0.553
GABPA
M4505_1.02
Homo sapiens
NVCCGGAAGYV

BRCTTCCGGBN
ChIP-seq
Gerstein et al.(2012)
H1-hESC_GABP_HudsonAlpha
0.553
Gabpa
M0693_1.02
Mus musculus
NRCCGGAARY

RYTTCCGGYN
PBM
Badis et al.(2009)
Gabpa_2829
0.553
GABPA
M4462_1.02
Homo sapiens
VVCCGGAAGYV

BRCTTCCGGBB
ChIP-seq
Gerstein et al.(2012)
GM12878_GABP_HudsonAlpha
0.553
GABPA
M3310_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GADP_01
0.553
GABPA
M3309_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GABP_B
0.553
GABPA
M3307_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GABPA_Q4
0.553
GABPA
M6252_1.02
Homo sapiens
VVVCCGGAAGTVV

BBACTTCCGGBBB
HocoMoco
Kulakovskiy et al.(2013)
GABPA_f1
0.553
GABPA
M3306_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GABPA_09
0.553
GABPA
M5475_1.02
Homo sapiens
RCCGGAAGTD

HACTTCCGGY
SELEX
Jolma et al.(2013)
GABPA_1
0.553
GABPA
M3305_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GABPA_08
0.553
GABPA
M4620_1.02
Homo sapiens
VVVVCCGGAAGTN

NACTTCCGGBBBB
ChIP-seq
Gerstein et al.(2012)
K562_GABP_HudsonAlpha
0.553
GABPA
M3304_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GABPA_07
0.553
GABPA
M4568_1.02
Homo sapiens
NBVVVSCGGAAGYVV

BBRCTTCCGSBBBVN
ChIP-seq
Gerstein et al.(2012)
HepG2_GABP_HudsonAlpha
0.553
ELK1
M3188_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ELK1_04
0.552
ELK1
M3187_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ELK1_03
0.552
ELK1
M3186_1.02
Homo sapiens
NNNDMCGGAARBNN

NNVYTTCCGKHNNN
Transfac
Matys et al.(2006)
V$ELK1_02
0.552
ELK1
M6207_1.02
Homo sapiens
VCMGGAARY

RYTTCCKGB
HocoMoco
Kulakovskiy et al.(2013)
ELK1_f1
0.552
ELK1
M1860_1.02
Homo sapiens
NNNMCGGAAR

YTTCCGKNNN
SELEX
Mathelier et al.(2014)
MA0028.1
0.552
ELK1
M5383_1.02
Homo sapiens
RCCGGAAGTN

NACTTCCGGY
SELEX
Jolma et al.(2013)
ELK1_4
0.552
Elk1
M0695_1.02
Mus musculus
NNCCGGAARY

RYTTCCGGNN
PBM
Wei et al.(2010)
Elk1
0.552
ELK1
M5382_1.02
Homo sapiens
NRYTTCCGSCGGAAGTN

NACTTCCGSCGGAARYN
SELEX
Jolma et al.(2013)
ELK1_3
0.552
ELK1
M5381_1.02
Homo sapiens
ACCGGAAGTD

HACTTCCGGT
SELEX
Jolma et al.(2013)
ELK1_2
0.552
ELK1
M5380_1.02
Homo sapiens
DCCGGAAGTN

NACTTCCGGH
SELEX
Jolma et al.(2013)
ELK1_1
0.552
ELK1
M3190_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ELK1_Q6
0.552
ELK1
M3189_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ELK1_Q4
0.552
ELK4
M0711_1.02
Tetraodon nigroviridis
CCGGAAGT

ACTTCCGG
PBM
Weirauch et al.(2014)
pTH6345
0.547
Elk3
M0692_1.02
Mus musculus
NNSCGGAAVY

RBTTCCGSNN
PBM
Wei et al.(2010)
Elk3
0.535
ELK3
M6208_1.02
Homo sapiens
VMCHGGAARTSC

GSAYTTCCDGKB
HocoMoco
Kulakovskiy et al.(2013)
ELK3_f1
0.535
Elk3
M6005_1.02
Mus musculus
ACCGGAAGTD

HACTTCCGGT
SELEX
Jolma et al.(2013)
Elk3_1
0.535
ELK3
M5384_1.02
Homo sapiens
RCCGGAAGTN

NACTTCCGGY
SELEX
Jolma et al.(2013)
ELK3_1
0.535
ELK3
M3604_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NET_Q6
0.535
Ets97D
M4953_1.02
Drosophila melanogaster
ACCGGAARY

RYTTCCGGT
B1H
Zhu et al.(2011)
Ets97D_SANGER_10_FBgn0004510
0.529
ETV2
M5421_1.02
Homo sapiens
DACCGGAARYD

HRYTTCCGGTH
SELEX
Jolma et al.(2013)
ETV2_1
0.512
For this family, TFs with SR scores > 0.500 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000242066 Ets 334 417
ENSP00000340853 Ets 316 399
ENSP00000382293 Ets 324 407
ENSP00000382294 Ets 311 394
ENSP00000384085 Ets 348 431
ENSP00000384138 Ets 294 377
ENSP00000385381 Ets 311 394
ENSP00000385551 Ets 334 417
ENSP00000385686 Ets 316 399
ENSP00000405327 Ets 334 417
ENSP00000411626 Ets 334 417

Links

Other Ets family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found