Pou3f2 (Mus musculus)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSMUSG00000095139 T238386_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of gene expression. Acts upstream of or within several processes, including epidermis development; nervous system development; and regulation of axonogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; eye; future brain; genitourinary system; and thymus. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pou3f2
M00552_2.00		 Mus musculus
NWWATBNN
NNVATWWN		 PBM
Berger et al.(2008)
Pou3f2_2824		 (Direct) (Direct)
Pou3f2
M09228_2.00		 Mus musculus
HWCATGMATATKYAWD
HWTRMATATKCATGWD		 Misc
Kulakovskiy et al.(2013)
PO3F2_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU3F2
M03313_2.00 		Homo sapiens
HWTGMATAWWTWA
TWAWWTATKCAWD		 SELEX
Jolma et al.(2013)
POU3F2_1 		1.000 1.000
POU3F2
M03314_2.00 		Homo sapiens
WTATGYWAATKW
WMATTWRCATAW		 SELEX
Jolma et al.(2013)
POU3F2_2 		1.000 1.000
POU3F2
M05473_2.00 		Homo sapiens
NTAATKAKATGCRN
NYGCATMTMATTAN		 SELEX
Yin et al.(2017)
POU3F2_eDBD_HT-SELEX_1 		1.000 1.000
POU3F2
M05474_2.00 		Homo sapiens
NYGCATWMATTAN
NTAATKWATGCRN		 SELEX
Yin et al.(2017)
POU3F2_eDBD_HT-SELEX_2 		1.000 1.000
POU3F2
M05475_2.00 		Homo sapiens
DHATGYGCATNH
DNATGCRCATDH		 SELEX
Yin et al.(2017)
POU3F2_eDBD_HT-SELEX_3 		1.000 1.000
POU3F2
M05476_2.00 		Homo sapiens
DTATGCWAATKAV
BTMATTWGCATAH		 SELEX
Yin et al.(2017)
POU3F2_eDBD_HT-SELEX_4 		1.000 1.000
POU3F2
M05477_2.00 		Homo sapiens
TAATKMNNNNNNTMATKA
TMATKANNNNNNKMATTA		 SELEX
Yin et al.(2017)
POU3F2_eDBD_HT-SELEX_5 		1.000 1.000
POU3F2
M09220_2.00 		Homo sapiens
YHCATKMMWWWBYMWNN
NNWKRVWWWKKMATGDR		 Misc
Kulakovskiy et al.(2013)
PO3F2_HUMAN.H11MO.0.A 		1.000 1.000
POU3F2
M10843_2.00 		Homo sapiens
NNCATBSDWAATVMRH
DYKBATTWHSVATGNN		 Transfac
Matys et al.(2006)
V$BRN2_01 		1.000 1.000
POU3F2
M10844_2.00 		Homo sapiens
ATGMATWWATTCAT
ATGAATWWATKCAT		 Transfac
Matys et al.(2006)
V$POU3F2_01 		1.000 1.000
POU3F2
M10845_2.00 		Homo sapiens
TTATGYTAAT
ATTARCATAA		 Transfac
Matys et al.(2006)
V$POU3F2_02 		1.000 1.000
POU3F2
M10846_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU3F2_Q2 		1.000 1.000
POU3F2
M05478_2.00 		Homo sapiens
NTAATGAKATGCGH
DCGCATMTCATTAN		 SELEX
Yin et al.(2017)
POU3F2_eDBD_Methyl-HT-SELEX_1 		1.000 1.000
POU3F2
M05479_2.00 		Homo sapiens
RCGCATAAATTAN
NTAATTTATGCGY		 SELEX
Yin et al.(2017)
POU3F2_eDBD_Methyl-HT-SELEX_2 		1.000 1.000
POU3F2
M05480_2.00 		Homo sapiens
DHATGCGCATDH
DHATGCGCATDH		 SELEX
Yin et al.(2017)
POU3F2_eDBD_Methyl-HT-SELEX_3 		1.000 1.000
POU3F2
M05481_2.00 		Homo sapiens
WTATGCWAATKAG
CTMATTWGCATAW		 SELEX
Yin et al.(2017)
POU3F2_eDBD_Methyl-HT-SELEX_4 		1.000 1.000
POU3F2
M05482_2.00 		Homo sapiens
TAATKANNNNNTAATKA
TMATTANNNNNTMATTA		 SELEX
Yin et al.(2017)
POU3F2_eDBD_Methyl-HT-SELEX_5 		1.000 1.000
For this family, TFs with SR scores > 0.993 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00552_2.00 POU 19 90
M00552_2.00 Homeodomain 109 165

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000136147 POU 267 338
ENSMUSP00000136147 Homeodomain 357 413

Links

Other Homeodomain,POU family TFs
Other Mus musculus TFs

29 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
POU3F2 Pan troglodytes ENSPTRG00000029496 I 1.000
Pou3f2 Rattus norvegicus ENSRNOG00000006908 I 1.000
ENSPPYG00000016860 Pongo abelii ENSPPYG00000016860 I 1.000
POU3F2 Procavia capensis ENSPCAG00000008737 I 1.000
POU3F2 Otolemur garnettii ENSOGAG00000024248 I 1.000
ENSPANG00000006100 Papio anubis ENSPANG00000006100 I 1.000
POU3F2 Sus scrofa ENSSSCG00000004346 I 1.000
Alligator_sinensis_CCG004860.1 Alligator sinensis Alligator_sinensis_CCG004860.1 I 1.000
Pvit_09307 Pogona vitticeps Pvit_09307 I 1.000
XP_002934918 Xenopus tropicalis XP_002934918 I 1.000
Ogr12763 Ophisaurus gracilis Ogr12763 I 1.000
Myotis_brandtii_Pou3f2_10025237 Myotis brandtii Myotis_brandtii_Pou3f2_10025237 I 1.000
Cmyd_10012071 Chelonia mydas Cmyd_10012071 I 1.000
ENSMPUG00000001529 Mustela putorius furo ENSMPUG00000001529 I 1.000
POU3F2 Monodelphis domestica ENSMODG00000018122 I 1.000
ENSCJAG00000001286 Callithrix jacchus ENSCJAG00000001286 I 1.000
ENSCPOG00000003168 Cavia porcellus ENSCPOG00000003168 I 1.000
POU3F2 Canis familiaris ENSCAFG00000029595 I 1.000
ENSBTAG00000024773 Bos taurus ENSBTAG00000024773 I 1.000
POU3F2 Anolis carolinensis ENSACAG00000023192 I 1.000
ENSAMEG00000011263 Ailuropoda melanoleuca ENSAMEG00000011263 I 1.000
ENSCSAG00000018978 Chlorocebus sabaeus ENSCSAG00000018978 I 1.000
POU3F2 Dasypus novemcinctus ENSDNOG00000007219 I 1.000
POU3F2 Gorilla gorilla ENSGGOG00000028066 I 1.000
POU3F2 Myotis lucifugus ENSMLUG00000016141 I 1.000
POU3F2 Homo sapiens ENSG00000184486 D 1.000
POU3F2 Echinops telfairi ENSETEG00000020341 I 1.000
ENSECAG00000015143 Equus caballus ENSECAG00000015143 I 1.000
ENSACAG00000008907 Anolis carolinensis ENSACAG00000008907 I 1.000