| NCBI Gene Info:Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Acts upstream of or within heart development; negative regulation of BMP signaling pathway; and negative regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in heart primordium; heart rudiment; heart tube; and margin. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6). [provided by Alliance of Genome Resources, Apr 2022] |