| NCBI Gene Info:Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including dauer entry; oviposition; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in excretory cell; hermaphrodite distal tip cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; cervical cancer; ovarian cancer; and pancreatic cancer. Orthologous to human SMAD2 (SMAD family member 2) and SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Apr 2022] |