TCF3 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000071564 T034250_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TCF3
M02775_2.00		 Homo sapiens
NVCACCTGBN
NVCAGGTGBN		 SELEX
Jolma et al.(2013)
TCF3_1		 (Direct) (Direct)
TCF3
M08710_2.00		 Homo sapiens
VVCASCTGCHN
NDGCAGSTGBB		 Misc
Kulakovskiy et al.(2013)
TFE2_HUMAN.H11MO.0.A		 (Direct) (Direct)
TCF3
M09791_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E12_Q6		 (Direct) (Direct)
TCF3
M09792_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E2A_Q6_01		 (Direct) (Direct)
TCF3
M09793_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E2A_Q6_02		 (Direct) (Direct)
TCF3
M09794_2.00		 Homo sapiens
VVVVMCACCTGCNBB
VVNGCAGGTGKBBBB		 Transfac
Matys et al.(2006)
V$E47_01		 (Direct) (Direct)
TCF3
M09795_2.00		 Homo sapiens
NNKWRCACCTGYDNNN
NNNHRCAGGTGYWMNN		 Transfac
Matys et al.(2006)
V$E47_02		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tcf3
M00753_2.00 		Mus musculus
VCACCTGBN
NVCAGGTGB		 PBM
Weirauch et al.(2013)
pTH3866 		0.884 0.981
Tcf3
M01723_2.00 		Mus musculus
NNVCACSTGB
VCASGTGBNN		 PBM
Weirauch et al.(2014)
pTH4580 		0.884 0.981
Tcf3
M00118_2.00 		Mus musculus
VCAYCTGB
VCAGRTGB		 PBM
Badis et al.(2009)
Tcfe2a_3865 		0.884 0.981
Tcf12
M01740_2.00 		Mus musculus
NVCAYCTGB
VCAGRTGBN		 PBM
Weirauch et al.(2014)
pTH5071 		0.884 0.865
TCF12
M04137_2.00 		Homo sapiens
VCACSTGB
VCASGTGB		 SELEX
Yin et al.(2017)
TCF12_eDBD_HT-SELEX 		0.884 0.865
Tcf12
M08062_2.00 		Mus musculus
RRCAGCTGNNN
NNNCAGCTGYY		 ChIP-seq
Mathelier et al.(2014)
MA0521.1 		0.884 0.865
TCF12
M07805_2.00 		Homo sapiens
NVDSCAGSTGB
VCASCTGSHBN		 ChIP-seq
Gerstein et al.(2012)
GM12878_TCF12_HudsonAlpha 		0.884 0.865
TCF12
M07806_2.00 		Homo sapiens
VCASCTGB
VCAGSTGB		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_TCF12_HudsonAlpha 		0.884 0.865
Tcf3
M09465_2.00 		Mus musculus
ABWTCAAAGS
SCTTTGAWVT		 Misc
Heinz et al.(2010)
mES-Tcf3_GSE11724 		0.886 0.942
TCF12
M08731_2.00 		Homo sapiens
CMCASCTGSH
DSCAGSTGKG		 Misc
Kulakovskiy et al.(2013)
HTF4_HUMAN.H11MO.0.A 		0.884 0.865
Tcf3
M09466_2.00 		Mus musculus
VCAGCTGBNN
NNVCAGCTGB		 Misc
Heinz et al.(2010)
proBcell-E2A_GSE21978 		0.886 0.942
Tcf12
M08762_2.00 		Mus musculus
VMCASCTGSH
DSCAGSTGKB		 Misc
Kulakovskiy et al.(2013)
HTF4_MOUSE.H11MO.0.A 		0.884 0.865
Tcf3
M09886_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E47_05 		0.886 0.942
TCF12
M09458_2.00 		Homo sapiens
NNVCAGCTGB
VCAGCTGBNN		 Misc
Heinz et al.(2010)
GM12878-Tcf12_GSE32465 		0.884 0.865
TCF12
M09858_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HEB_Q6 		0.884 0.865
TCF12
M09859_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HTF4_Q2 		0.884 0.865
TCF12
M09860_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TCF12_01 		0.884 0.865
TCF12
M09861_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TCF12_03 		0.884 0.865
TCF12
M09862_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TCF12_05 		0.884 0.865
TCF12
M04138_2.00 		Homo sapiens
NCAYCTGN
NCAGRTGN		 SELEX
Yin et al.(2017)
TCF12_eDBD_Methyl-HT-SELEX 		0.884 0.865
Tcf4
M01750_2.00 		Mus musculus
VCAGVTGBN
NVCABCTGB		 PBM
Weirauch et al.(2014)
pTH5101 		0.882 0.865
TCF4
M02807_2.00 		Homo sapiens
HRCACCTGBN
NVCAGGTGYD		 SELEX
Jolma et al.(2013)
TCF4_1 		0.882 0.865
TCF4
M02808_2.00 		Homo sapiens
NVCACCTBBN
NVVAGGTGBN		 SELEX
Jolma et al.(2013)
TCF4_2 		0.882 0.865
TCF4
M02728_2.00 		Homo sapiens
RCACCTG
CAGGTGY		 SELEX
Jolma et al.(2010)
TCF4_dimer 		0.882 0.865
TCF4
M04214_2.00 		Homo sapiens
VCACCTGB
VCAGGTGB		 SELEX
Yin et al.(2017)
TCF4_eDBD_HT-SELEX 		0.882 0.865
Tcf4
M08775_2.00 		Mus musculus
HRCACCTGB
VCAGGTGYD		 Misc
Kulakovskiy et al.(2013)
ITF2_MOUSE.H11MO.0.B 		0.882 0.865
TCF4
M09461_2.00 		Homo sapiens
ASWTCAAAGRVN
NBYCTTTGAWST		 Misc
Heinz et al.(2010)
Hct116-Tcf4_SRA012054 		0.882 0.865
TCF4
M04215_2.00 		Homo sapiens
VCACCTGN
NCAGGTGB		 SELEX
Yin et al.(2017)
TCF4_eDBD_Methyl-HT-SELEX 		0.882 0.865
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000262965 bHLH 550 603
ENSP00000344375 bHLH 496 549
ENSP00000378813 bHLH 554 607
ENSP00000396363 bHLH 575 628
ENSP00000465510 bHLH 55 108
ENSP00000465549 bHLH 75 128
ENSP00000466565 bHLH 116 169
ENSP00000466952 bHLH 210 263
ENSP00000467508 bHLH 61 114
ENSP00000468481 bHLH 100 153
ENSP00000468487 bHLH 547 600
ENSP00000480564 bHLH 550 603

Links

Other bHLH family TFs
Other Homo sapiens TFs

217 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
POPTR_0012s03750 Populus trichocarpa POPTR_0012s03750 N
POPTR_0015s05200 Populus trichocarpa POPTR_0015s05200 N
SapurV1A.0074s0330 Salix purpurea SapurV1A.0074s0330 N
SapurV1A.0074s0340 Salix purpurea SapurV1A.0074s0340 N
SapurV1A.1169s0060 Salix purpurea SapurV1A.1169s0060 N