CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Arntl
(
Rattus norvegicus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSRNOG00000014448
T037207_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Arntl
M09889_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BMAL1_01
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Arntl
M01751_2.00
Mus musculus
NCACGTGAYN
NRTCACGTGN
PBM
Weirauch et al.(2014)
pTH5064
0.914
1.000
ARNTL
M02787_2.00
Homo sapiens
GTCACGTGAC
GTCACGTGAC
SELEX
Jolma et al.(2013)
ARNTL_1
0.914
1.000
ARNTL
M04124_2.00
Homo sapiens
RDCACGTGHN
NDCACGTGHY
SELEX
Yin et al.(2017)
ARNTL_eDBD_HT-SELEX
0.914
1.000
ARNTL
M08725_2.00
Homo sapiens
NVDCACGTGBN
NVCACGTGHBN
Misc
Kulakovskiy et al.(2013)
BMAL1_HUMAN.H11MO.0.A
0.914
1.000
Arntl
M08776_2.00
Mus musculus
VCACGTGMN
NKCACGTGB
Misc
Kulakovskiy et al.(2013)
BMAL1_MOUSE.H11MO.0.A
0.914
1.000
Arntl
M09478_2.00
Mus musculus
CACGTGNN
NNCACGTG
Misc
Heinz et al.(2010)
Liver-Bmal1_GSE39860
0.914
1.000
ARNTL
M09841_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BMAL1_Q6
0.914
1.000
ARNTL
M04125_2.00
Homo sapiens
NDCACRTGHY
RDCAYGTGHN
SELEX
Yin et al.(2017)
ARNTL_eDBD_Methyl-HT-SELEX
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000042830
bHLH
73
126
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
Links
Other
bHLH
family TFs
Other
Rattus norvegicus
TFs
88 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy