CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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tra-1
(
Caenorhabditis elegans
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
WBGene00006604
T131576_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Involved in several processes, including female somatic sex determination; negative regulation of transcription by RNA polymerase II; and positive regulation of neuron apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including germ line; gonad; intestine; nervous system; and somatic gonad precursor. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; Pallister-Hall syndrome; anodontia; holoprosencephaly 9; and synostosis (multiple). Orthologous to human GLI1 (GLI family zinc finger 1); GLI2 (GLI family zinc finger 2); and GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
tra-1
M10386_2.00
Caenorhabditis elegans
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
N$TRA1_01
(Direct)
(Direct)
tra-1
M10387_2.00
Caenorhabditis elegans
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
N$TRA1_02
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
Y47D3A.6a
C2H2 ZF
243
269
WRCEWEGCDRNETFKALYMLIVHVRRH
Y47D3A.6a
C2H2 ZF
276
299
KCEYPGCGKEYSRLENLKTHRRTH
Y47D3A.6a
C2H2 ZF
305
330
YKCEFADCEKAFSNASDRAKHQNRTH
Y47D3A.6a
C2H2 ZF
336
361
YSCQIPQCTKSYTDPSSLRKHIKAVH
Y47D3A.6b
C2H2 ZF
207
232
LTCRWKSCNSSFQTLKALVDHVQESH
Y47D3A.6b
C2H2 ZF
243
269
WRCEWEGCDRNETFKALYMLIVHVRRH
Links
Other
C2H2 ZF
family TFs
Other
Caenorhabditis elegans
TFs
4 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy