SIX6 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000184302 T209927_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SIX6
M00325_2.00		 Homo sapiens
NNNDATMB
VKATHNNN		 PBM
Barrera et al.(2016)
SIX6_H141N		 (Direct) (Direct)
SIX6
M00326_2.00		 Homo sapiens
NNDATMB
VKATHNN		 PBM
Barrera et al.(2016)
SIX6_REF		 (Direct) (Direct)
SIX6
M00327_2.00		 Homo sapiens
NHDAYMBNN
NNVKRTHDN		 PBM
Barrera et al.(2016)
SIX6_T165A		 (Direct) (Direct)
SIX6
M05357_2.00		 Homo sapiens
NNYGATASVB
VBSTATCRNN		 SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX		 (Direct) (Direct)
SIX6
M05358_2.00		 Homo sapiens
VBVYAYCRNN
NNYGRTRBVB		 SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Six6
M00169_2.00 		Mus musculus
NNAYMNN
NNKRTNN		 PBM
Badis et al.(2009)
Six6_2267 		0.867 1.000
Six6
M00412_2.00 		Mus musculus
NNNTGATAYCN
NGRTATCANNN		 PBM
Berger et al.(2008)
Six6_2267 		0.867 1.000
Six3
M00483_2.00 		Mus musculus
NNNAYMN
NKRTNNN		 PBM
Berger et al.(2008)
Six3_1732 		0.865 0.982
SIX3
M05159_2.00 		Homo sapiens
NNYGATABBN
NVVTATCRNN		 SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX 		0.865 0.982
SIX3
M10698_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX3_Q6 		0.865 0.982
SIX3
M05160_2.00 		Homo sapiens
NNYGATABVB
VBVTATCRNN		 SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX 		0.865 0.982
six3
M02102_2.00 		Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN		 PBM
Weirauch et al.(2014)
pTH5928 		0.865 0.947
Optix
M02124_2.00 		Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN		 PBM
Weirauch et al.(2014)
pTH5437 		0.865 0.930
Optix
M03850_2.00 		Drosophila melanogaster
TAATYTAATTA
TAATTARATTA		 SELEX
Nitta et al.(2015)
Optix_1 		0.865 0.930
Optix
M06526_2.00 		Drosophila melanogaster
TGATA
TATCA		 B1H
Mathelier et al.(2014)
MA0199.1 		0.865 0.930
Optix
M06327_2.00 		Drosophila melanogaster
HHVTGATA
TATCABDD		 B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360 		0.865 0.930
Optix
M06328_2.00 		Drosophila melanogaster
NNNTGATA
TATCANNN		 B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360 		0.865 0.930
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00325_2.00 Homeodomain 11 67
M00326_2.00 Homeodomain 11 67
M00327_2.00 Homeodomain 11 67

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000328596 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

296 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Bm3498 Brugia malayi Bm3498 I
TBX15 Bos taurus ENSBTAG00000007767 I
TBX10 Canis familiaris ENSCAFG00000011264 I
ENSCSAVG00000000786 Ciona savignyi ENSCSAVG00000000786 I
ENSDORG00000012736 Dipodomys ordii ENSDORG00000012736 I
Tbx22 Mus musculus ENSMUSG00000031241 I
ENSOANG00000020395 Ornithorhynchus anatinus ENSOANG00000020395 I
ENSOANG00000029773 Ornithorhynchus anatinus ENSOANG00000029773 I
TBX5 Vicugna pacos ENSVPAG00000009445 I
SINV17750 Solenopsis invicta SINV17750 I
Hsal_04126--XP_001122560.1_APIME Harpegnathos saltator Hsal_04126--XP_001122560.1_APIME I
ACEP16054 Atta cephalotes ACEP16054 N
ACEP16128 Atta cephalotes ACEP16128 N
ACEP18777 Atta cephalotes ACEP18777 N
ADAC010198 Anopheles darlingi ADAC010198 N
AGAP011712 Anopheles gambiae AGAP011712 N
BGIBMGA003174 Bombyx mori BGIBMGA003174 N
BGIBMGA006719 Bombyx mori BGIBMGA006719 N
BGIBMGA012898 Bombyx mori BGIBMGA012898 N
CBG08000 Caenorhabditis briggsae CBG08000 N
ENSCJAG00000000826 Callithrix jacchus ENSCJAG00000000826 N
ENSETEG00000007920 Echinops telfairi ENSETEG00000007920 N
ENSPCAG00000011680 Procavia capensis ENSPCAG00000011680 N
ENSXMAG00000002873 Xiphophorus maculatus ENSXMAG00000002873 N
ENSXMAG00000005990 Xiphophorus maculatus ENSXMAG00000005990 N
GF19461 Drosophila ananassae FBgn0096470 N
GG18707 Drosophila erecta FBgn0110916 N
GD16691 Drosophila simulans FBgn0188280 N
HMEL004264 Heliconius melpomene HMEL004264 N
ISCW019287 Ixodes scapularis ISCW019287 N
KGM_15500 Danaus plexippus KGM_15500 N
L798_01365 Zootermopsis nevadensis L798_01365 N
L798_14238 Zootermopsis nevadensis L798_14238 N
PPA14512 Pristionchus pacificus PPA14512 N
SINV16738 Solenopsis invicta SINV16738 N
SINV20004 Solenopsis invicta SINV20004 N
Smp_156650 Schistosoma mansoni Smp_156650 N
YQE_06268 Dendroctonus ponderosae YQE_06268 N
YQE_10906 Dendroctonus ponderosae YQE_10906 N
Afo_R005342 Aptenodytes forsteri Afo_R005342 N
Alligator_sinensis_CCG010046.1 Alligator sinensis Alligator_sinensis_CCG010046.1 N
Brh_R011566 Buceros rhinoceros Brh_R011566 N
Cflo_02417--XP_001121225.1_APIME Camponotus floridanus Cflo_02417--XP_001121225.1_APIME N
Hsal_09269--XP_394607.3_APIME Harpegnathos saltator Hsal_09269--XP_394607.3_APIME N
Ogr11253 Ophisaurus gracilis Ogr11253 N
Tal_R004166 Tyto alba Tal_R004166 N
Tal_R010698 Tyto alba Tal_R010698 N
Ocbimv22013221m.g Octopus bimaculoides Ocbimv22013221m.g N
CLEC007098 Cimex lectularius CLEC007098 N
HHAL010563-PA Halyomorpha halys HHAL010563-PA N
LCUP008640 Lucilia cuprina LCUP008640 N
LDEC010813 Leptinotarsa decemlineata LDEC010813 N
SNAPOd2T00025688001 Oikopleura dioica SNAPOd2T00025688001 N
AALB000417 Anopheles albimanus AALB000417 N
AALB008493 Anopheles albimanus AALB008493 N
AARA011013 Anopheles arabiensis AARA011013 N
AATE002453 Anopheles atroparvus AATE002453 N
ACHR009374 Anopheles christyi ACHR009374 N
ACUA008906 Anopheles culicifacies ACUA008906 N
ACUA018702 Anopheles culicifacies ACUA018702 N
ACUA028082 Anopheles culicifacies ACUA028082 N
ADIR010892 Anopheles dirus ADIR010892 N
AEPI001841 Anopheles epiroticus AEPI001841 N
AEPI001845 Anopheles epiroticus AEPI001845 N
AEPI004511 Anopheles epiroticus AEPI004511 N
AFUN001004 Anopheles funestus AFUN001004 N
AFUN010567 Anopheles funestus AFUN010567 N
AMEM005938 Anopheles merus AMEM005938 N
AMEM014364 Anopheles merus AMEM014364 N
AMIN000991 Anopheles minimus AMIN000991 N
AMIN008749 Anopheles minimus AMIN008749 N
AQUA000257 Anopheles quadriannulatus AQUA000257 N
AQUA010449 Anopheles quadriannulatus AQUA010449 N
ASTEI10438 Anopheles stephensi ASTEI10438 N
BGLB011455 Biomphalaria glabrata BGLB011455 N
PPAI002123 Phlebotomus papatasi PPAI002123 N
PPAI007567 Phlebotomus papatasi PPAI007567 N
A_04261 Schistosoma haematobium A_04261 N
ANCCEY_00583 Ancylostoma ceylanicum ANCCEY_00583 N
ANCDUO_17822 Ancylostoma duodenale ANCDUO_17822 N
ANCDUO_24135 Ancylostoma duodenale ANCDUO_24135 N
ANCDUO_27140 Ancylostoma duodenale ANCDUO_27140 N
CGOC_0001264301 Cylicostephanus goldi CGOC_0001264301 N
D915_02167 Fasciola hepatica D915_02167 N
D915_04736 Fasciola hepatica D915_04736 N
DICVIV_10715 Dictyocaulus viviparus DICVIV_10715 N
DME_0000818901 Dracunculus medinensis DME_0000818901 N
ECANG7_07880 Echinococcus canadensis ECANG7_07880 N
ECPE_0000395601 Echinostoma caproni ECPE_0000395601 N
EVEC_0000447801 Enterobius vermicularis EVEC_0000447801 N
GPUH_0002190501 Gongylonema pulchrum GPUH_0002190501 N
HCOI01136500 Haemonchus contortus HCOI01136500 N
L596_g4935 Steinernema carpocapsae L596_g4935 N
L892_g20532 Steinernema scapterisci L892_g20532 N
NBR_0000542501 Nippostrongylus brasiliensis NBR_0000542501 N
NBR_0001177301 Nippostrongylus brasiliensis NBR_0001177301 N
NBR_0002182001 Nippostrongylus brasiliensis NBR_0002182001 N
NECAME_11635 Necator americanus NECAME_11635 N
NECAME_19347 Necator americanus NECAME_19347 N
nOo.2.0.1.g12774 Onchocerca ochengi nOo.2.0.1.g12774 N
nOo.2.0.1.g12879 Onchocerca ochengi nOo.2.0.1.g12879 N
OESDEN_02780 Oesophagostomum dentatum OESDEN_02780 N
OESDEN_07954 Oesophagostomum dentatum OESDEN_07954 N
OFLC_0001184101 Onchocerca flexuosa OFLC_0001184101 N
PXEA_0000704401 Protopolystoma xenopodis PXEA_0000704401 N
PXEA_0001803801 Protopolystoma xenopodis PXEA_0001803801 N
SMTD_0001100101 Schistosoma mattheei SMTD_0001100101 N
SMTD_0001779301 Schistosoma mattheei SMTD_0001779301 N
SMUV_0000075501 Syphacia muris SMUV_0000075501 N
SPER_0002063901 Spirometra erinaceieuropaei SPER_0002063901 N
SPER_0003769001 Spirometra erinaceieuropaei SPER_0003769001 N
SPER_0003779701 Spirometra erinaceieuropaei SPER_0003779701 N
SVUK_0001851801 Strongylus vulgaris SVUK_0001851801 N
TELCIR_17829 Teladorsagia circumcincta TELCIR_17829 N
TRE_0001207201 Trichobilharzia regenti TRE_0001207201 N
TsM_001062700 Taenia solium TsM_001062700 N