TF Information

HHAL007363-PA *(Halyomorpha halys)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00046 (Homeobox)	IPR001356	HHAL007363-PA	T229851_2.00	Misc (2018-Jan-19)
NCBI Gene Info: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
MEIS3 M03093_2.00	Homo sapiens	DTGACANN	NNTGTCAH	SELEX Jolma et al.(2013) MEIS3_1	0.815	0.667
MEIS3 M03094_2.00	Homo sapiens	TGACAGSTGTCA	TGACASCTGTCA	SELEX Jolma et al.(2013) MEIS3_2	0.815	0.667
MEIS3 M04951_2.00	Homo sapiens	TGWCABVTGWCA	TGWCABVTGWCA	SELEX Yin et al.(2017) MEIS3_eDBD_HT-SELEX	0.815	0.667
MEIS3 M04952_2.00	Homo sapiens	YGWCABVTGWCR	YGWCABVTGWCR	SELEX Yin et al.(2017) MEIS3_eDBD_Methyl-HT-SELEX	0.815	0.667
Q5EVH4_OIKDI M02227_2.00	Oikopleura dioica	NTGACAKN	NMTGTCAN	PBM Weirauch et al.(2014) pTH6041	0.792	0.769
KNAT7 M01064_2.00	Arabidopsis thaliana	TGACRKST	ASMYGTCA	PBM Sullivan et al.(2014) pTH9798	0.673	0.487
KNAT4 M01238_2.00	Arabidopsis thaliana	NNGACNNNN	NNNNGTCNN	PBM Lambert et al.(2019) pTH9968	0.669	0.487
KNAT3 M02051_2.00	Arabidopsis thaliana	NNNGACVBNN	NNVBGTCNNN	PBM Weirauch et al.(2014) pTH7600	0.669	0.462
HOS66 M02156_2.00	Oryza sativa	NNNNDHNN	NNDHNNNN	PBM Weirauch et al.(2014) pTH8332	0.634	0.487
For this family, TFs with SR scores > 0.599* will likely have a similar motif*