CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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twist1b
(
Danio rerio
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSDARG00000076010
T033724_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; pharyngeal system development; and regulation of bone mineralization. Predicted to be located in nucleus. Is expressed in several structures, including brain; cardiovascular system; cranial vault; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TWIST1
M08052_2.00
Homo sapiens
NNNCCAGATGTNN
NNACATCTGGNNN
ChIP-seq
Mathelier et al.(2014)
MA1123.1
0.890
1.000
TWIST1
M08722_2.00
Homo sapiens
WAATBRRWWMCAGATGB
VCATCTGKWWYYVATTW
Misc
Kulakovskiy et al.(2013)
TWST1_HUMAN.H11MO.0.A
0.890
1.000
Twist1
M08766_2.00
Mus musculus
WAATNRRWWMCAKMTGB
VCAKMTGKWWYYNATTW
Misc
Kulakovskiy et al.(2013)
TWST1_MOUSE.H11MO.0.B
0.890
1.000
TWIST1
M09831_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TWIST_Q6_01
0.890
1.000
TWIST1
M09832_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TWIST_Q6
0.890
1.000
Twist2
M01718_2.00
Mus musculus
NACATATGKN
NMCATATGTN
PBM
Weirauch et al.(2014)
pTH5033
0.890
0.961
twi
M03605_2.00
Drosophila melanogaster
MACACRTGKB
VMCAYGTGTK
SELEX
Nitta et al.(2015)
twi_1
0.883
0.882
twi
M03606_2.00
Drosophila melanogaster
MNDCMYRHCGVD
HBCGDYRKGHNK
SELEX
Nitta et al.(2015)
twi_2
0.883
0.882
twi
M05955_2.00
Drosophila melanogaster
VCCAGATGTB
VACATCTGGB
B1H
Zhu et al.(2011)
twi_da_SANGER_5_FBgn0003900
0.883
0.882
twi
M05956_2.00
Drosophila melanogaster
NAACAYRTGSNV
BNSCAYRTGTTN
B1H
Zhu et al.(2011)
twi_FlyReg_FBgn0003900
0.883
0.882
twi
M07538_2.00
Drosophila melanogaster
NAACAYRTGSNV
BNSCAYRTGTTN
DNaseI footprinting
Mathelier et al.(2014)
MA0249.1
0.883
0.882
twi
M09657_2.00
Drosophila melanogaster
AACAKVTGBBVD
HBVVCABMTGTT
Misc
Kulakovskiy et al.(2009)
twi
0.883
0.882
twi
M09892_2.00
Drosophila melanogaster
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
I$TWI_Q6
0.883
0.882
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000052926
bHLH
76
126
QRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFL
ENSDARP00000124909
bHLH
76
126
QRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFL
Links
Other
bHLH
family TFs
Other
Danio rerio
TFs
238 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy