CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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TWIST1
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000122691
T034273_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TWIST1
M08052_2.00
Homo sapiens
NNNCCAGATGTNN
NNACATCTGGNNN
ChIP-seq
Mathelier et al.(2014)
MA1123.1
(Direct)
(Direct)
TWIST1
M08722_2.00
Homo sapiens
WAATBRRWWMCAGATGB
VCATCTGKWWYYVATTW
Misc
Kulakovskiy et al.(2013)
TWST1_HUMAN.H11MO.0.A
(Direct)
(Direct)
TWIST1
M09831_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TWIST_Q6_01
(Direct)
(Direct)
TWIST1
M09832_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TWIST_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Twist1
M08766_2.00
Mus musculus
WAATNRRWWMCAKMTGB
VCAKMTGKWWYYNATTW
Misc
Kulakovskiy et al.(2013)
TWST1_MOUSE.H11MO.0.B
0.914
1.000
Twist2
M01718_2.00
Mus musculus
NACATATGKN
NMCATATGTN
PBM
Weirauch et al.(2014)
pTH5033
0.914
0.962
twi
M03605_2.00
Drosophila melanogaster
MACACRTGKB
VMCAYGTGTK
SELEX
Nitta et al.(2015)
twi_1
0.859
0.865
twi
M03606_2.00
Drosophila melanogaster
MNDCMYRHCGVD
HBCGDYRKGHNK
SELEX
Nitta et al.(2015)
twi_2
0.859
0.865
twi
M05955_2.00
Drosophila melanogaster
VCCAGATGTB
VACATCTGGB
B1H
Zhu et al.(2011)
twi_da_SANGER_5_FBgn0003900
0.859
0.865
twi
M05956_2.00
Drosophila melanogaster
NAACAYRTGSNV
BNSCAYRTGTTN
B1H
Zhu et al.(2011)
twi_FlyReg_FBgn0003900
0.859
0.865
twi
M07538_2.00
Drosophila melanogaster
NAACAYRTGSNV
BNSCAYRTGTTN
DNaseI footprinting
Mathelier et al.(2014)
MA0249.1
0.859
0.865
twi
M09657_2.00
Drosophila melanogaster
AACAKVTGBBVD
HBVVCABMTGTT
Misc
Kulakovskiy et al.(2009)
twi
0.859
0.865
twi
M09892_2.00
Drosophila melanogaster
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
I$TWI_Q6
0.859
0.865
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000242261
bHLH
109
160
QRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLY
ENSP00000346582
bHLH
42
93
QRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLY
ENSP00000416986
bHLH
1
28
XIIPTLPSDKLSKIQTLKLAARYIDFLY
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
236 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSOARG00000009754
Ovis aries
ENSOARG00000009754
I
0.914
TWIST2
Oryctolagus cuniculus
ENSOCUG00000004073
I
0.914
ENSOARG00000000265
Ovis aries
ENSOARG00000000265
I
0.914
ENSOANG00000012950
Ornithorhynchus anatinus
ENSOANG00000012950
I
0.914
ENSNLEG00000019264
Nomascus leucogenys
ENSNLEG00000019264
I
0.914
TWIST1
Ornithorhynchus anatinus
ENSOANG00000009614
I
0.914
TWIST2
Otolemur garnettii
ENSOGAG00000029007
I
0.914
TWIST2
Ochotona princeps
ENSOPRG00000017069
I
0.914
ENSPTRG00000018960
Pan troglodytes
ENSPTRG00000018960
I
0.914
TWIST2
Pan troglodytes
ENSPTRG00000033910
I
0.914
ENSPSIG00000012843
Pelodiscus sinensis
ENSPSIG00000012843
I
0.914
ENSPPYG00000017754
Pongo abelii
ENSPPYG00000017754
I
0.914
TWIST1
Oryzias latipes
ENSORLG00000004012
I
0.914
ENSPANG00000001578
Papio anubis
ENSPANG00000001578
I
0.914
ENSNLEG00000011342
Nomascus leucogenys
ENSNLEG00000011342
I
0.914
Twist1
Mus musculus
ENSMUSG00000035799
D
0.914
ENSMGAG00000002218
Meleagris gallopavo
ENSMGAG00000002218
I
0.914
TWIST1
Myotis lucifugus
ENSMLUG00000007047
I
0.914
ENSMEUG00000013853
Macropus eugenii
ENSMEUG00000013853
I
0.914
ENSLOCG00000018350
Lepisosteus oculatus
ENSLOCG00000018350
I
0.914
TWIST2
Loxodonta africana
ENSLAFG00000032174
I
0.914
ENSLOCG00000017835
Lepisosteus oculatus
ENSLOCG00000017835
I
0.914
TWIST2
Myotis lucifugus
ENSMLUG00000023316
I
0.914
TWIST1
Macaca mulatta
ENSMMUG00000011173
I
0.914
ENSMPUG00000019429
Mustela putorius furo
ENSMPUG00000019429
I
0.914
Twist2
Mus musculus
ENSMUSG00000007805
D
0.914
TWIST1
Monodelphis domestica
ENSMODG00000023924
I
0.914
ENSMODG00000001412
Monodelphis domestica
ENSMODG00000001412
I
0.914
TWIST2
Macaca mulatta
ENSMMUG00000021909
I
0.914
TWIST1
Pteropus vampyrus
ENSPVAG00000001710
I
0.914
Twist1
Rattus norvegicus
ENSRNOG00000011101
I
0.914
Myotis_brandtii_Twist1_10031742
Myotis brandtii
Myotis_brandtii_Twist1_10031742
I
0.914
Ogr06591
Ophisaurus gracilis
Ogr06591
I
0.914
Gfo_R012065
Geospiza fortis
Gfo_R012065
I
0.914
ENSP00000405176-D1
Bos grunniens
ENSP00000405176-D1
I
0.914
Brh_R012765
Buceros rhinoceros
Brh_R012765
I
0.914
Cmyd_10006750
Chelonia mydas
Cmyd_10006750
I
0.914
Ogr11552
Ophisaurus gracilis
Ogr11552
I
0.914
Ogr11553
Ophisaurus gracilis
Ogr11553
I
0.914
CLEC011700
Cimex lectularius
CLEC011700
I
0.914
LDEC006528
Leptinotarsa decemlineata
LDEC006528
I
0.914
Ocbimv22015922m.g
Octopus bimaculoides
Ocbimv22015922m.g
I
0.914
fgenesh2_pm.scaffold_217000008
Branchiostoma floridae
fgenesh2_pm.scaffold_217000008
I
0.914
Pvit_02271
Pogona vitticeps
Pvit_02271
I
0.914
estExt_gwp.C_4170045
Branchiostoma floridae
estExt_gwp.C_4170045
I
0.914
Alligator_sinensis_CCG008488.1
Alligator sinensis
Alligator_sinensis_CCG008488.1
I
0.914
Alligator_sinensis_CCG002585.1
Alligator sinensis
Alligator_sinensis_CCG002585.1
I
0.914
ENSSTOG00000004633
Ictidomys tridecemlineatus
ENSSTOG00000004633
I
0.914
TWIST1
Taeniopygia guttata
ENSTGUG00000002643
I
0.914
TWIST2
Sus scrofa
ENSSSCG00000016343
I
0.914
TWIST1
Sus scrofa
ENSSSCG00000015370
I
0.914
Twist2
Rattus norvegicus
ENSRNOG00000020355
I
0.914
ENSSHAG00000003328
Sarcophilus harrisii
ENSSHAG00000003328
I
0.914
L798_05856
Zootermopsis nevadensis
L798_05856
I
0.914
SINV20920
Solenopsis invicta
SINV20920
I
0.914
Aan_R002857
Calypte anna
Aan_R002857
I
0.914
Afo_R010658
Aptenodytes forsteri
Afo_R010658
I
0.914
Aan_R001044
Calypte anna
Aan_R001044
I
0.914
YQE_04855
Dendroctonus ponderosae
YQE_04855
I
0.914
TC014598
Tribolium castaneum
TC014598
I
0.914
ENSLACG00000013366
Latimeria chalumnae
ENSLACG00000013366
I
0.914
ENSTGUG00000003194
Taeniopygia guttata
ENSTGUG00000003194
I
0.914
ENSCSAG00000019610
Chlorocebus sabaeus
ENSCSAG00000019610
I
0.914
TWIST1
Dasypus novemcinctus
ENSDNOG00000037354
I
0.914
TWIST2
Dasypus novemcinctus
ENSDNOG00000002434
I
0.914
TWIST1
Erinaceus europaeus
ENSEEUG00000015333
I
0.914
TWIST2
Echinops telfairi
ENSETEG00000009809
I
0.914
ENSFALG00000009781
Ficedula albicollis
ENSFALG00000009781
I
0.914
ENSETEG00000013115
Echinops telfairi
ENSETEG00000013115
I
0.914
ENSAPLG00000000878
Anas platyrhynchos
ENSAPLG00000000878
I
0.914
ENSAPLG00000007177
Anas platyrhynchos
ENSAPLG00000007177
I
0.914
TWIST2
Cavia porcellus
ENSCPOG00000025980
I
0.914
ENSCSAG00000018801
Chlorocebus sabaeus
ENSCSAG00000018801
I
0.914
TWIST2
Callithrix jacchus
ENSCJAG00000023006
I
0.914
TWIST2
Canis familiaris
ENSCAFG00000012469
I
0.914
TWIST2
Bos taurus
ENSBTAG00000021444
I
0.914
TWIST1
Bos taurus
ENSBTAG00000046922
I
0.914
ENSFALG00000014990
Ficedula albicollis
ENSFALG00000014990
I
0.914
ENSDORG00000012866
Dipodomys ordii
ENSDORG00000012866
I
0.914
twist1
Anolis carolinensis
ENSACAG00000011825
I
0.914
ENSGALG00000004274
Gallus gallus
ENSGALG00000004274
I
0.914
ENSGALG00000026059
Gallus gallus
ENSGALG00000026059
I
0.914
DAPPUDRAFT_320202
Daphnia pulex
DAPPUDRAFT_320202
I
0.914
ENSLACG00000012096
Latimeria chalumnae
ENSLACG00000012096
I
0.914
ENSAMEG00000008556
Ailuropoda melanoleuca
ENSAMEG00000008556
I
0.914
twist1b
Gasterosteus aculeatus
ENSGACG00000008070
I
0.914
ENSAMEG00000020165
Ailuropoda melanoleuca
ENSAMEG00000020165
I
0.914
TWIST2
Homo sapiens
ENSG00000233608
I
0.914
AGAP011985
Anopheles gambiae
AGAP011985
I
0.903
ENSAMXG00000025657
Astyanax mexicanus
ENSAMXG00000025657
I
0.903
ENSACAG00000009715
Anolis carolinensis
ENSACAG00000009715
I
0.903
ENSAMXG00000025095
Astyanax mexicanus
ENSAMXG00000025095
I
0.903
CapteG154829
Capitella teleta
CapteG154829
I
0.903
twist3
Takifugu rubripes
ENSTRUG00000012607
I
0.903
CGI_10006631
Crassostrea gigas
CGI_10006631
I
0.903
ENSXMAG00000019999
Xiphophorus maculatus
ENSXMAG00000019999
I
0.903
ACOM023427
Anopheles coluzzii
ACOM023427
I
0.903
AATE005140
Anopheles atroparvus
AATE005140
I
0.903
AAEL002902
Aedes aegypti
AAEL002902
I
0.903
Sakowv30001350m.g
Saccoglossus kowalevskii
Sakowv30001350m.g
I
0.903
AFAF020800
Anopheles farauti
AFAF020800
I
0.903
PHUM396880
Pediculus humanus
PHUM396880
I
0.903
BGLB003400
Biomphalaria glabrata
BGLB003400
I
0.903
ASTEI05879
Anopheles stephensi
ASTEI05879
I
0.903
AMEC000330
Anopheles melas
AMEC000330
I
0.903
ACYPI001448
Acyrthosiphon pisum
ACYPI001448
I
0.903
twist3
Tetraodon nigroviridis
ENSTNIG00000000441
I
0.903
ENSPMAG00000010126
Petromyzon marinus
ENSPMAG00000010126
I
0.903
ENSPMAG00000003993
Petromyzon marinus
ENSPMAG00000003993
I
0.903
ENSGMOG00000002790
Gadus morhua
ENSGMOG00000002790
I
0.903
RPRC000323
Rhodnius prolixus
RPRC000323
I
0.901
CapteG111042
Capitella teleta
CapteG111042
I
0.900
ENSGALG00000006321
Gallus gallus
ENSGALG00000006321
I
0.894
Afo_R013292
Aptenodytes forsteri
Afo_R013292
I
0.894
Alligator_sinensis_CCG005115.1
Alligator sinensis
Alligator_sinensis_CCG005115.1
I
0.894
Cmyd_10002489
Chelonia mydas
Cmyd_10002489
I
0.894
Ogr01719
Ophisaurus gracilis
Ogr01719
I
0.894
ENSLACG00000019113
Latimeria chalumnae
ENSLACG00000019113
I
0.894
ENSPSIG00000001961
Pelodiscus sinensis
ENSPSIG00000001961
I
0.894
Pvit_05844
Pogona vitticeps
Pvit_05844
I
0.894
TWIST1
Meleagris gallopavo
ENSMGAG00000009311
I
0.894
D917_00468
Trichinella nativa
D917_00468
I
0.890
ENSONIG00000020502
Oreochromis niloticus
ENSONIG00000020502
I
0.890
ENSXMAG00000020142
Xiphophorus maculatus
ENSXMAG00000020142
I
0.890
ENSAMXG00000025610
Astyanax mexicanus
ENSAMXG00000025610
I
0.890
twist1
Oryzias latipes
ENSORLG00000007251
I
0.890
Cflo_04586--NP_001011637.1_APIME
Camponotus floridanus
Cflo_04586--NP_001011637.1_APIME
I
0.890
ACEP23430
Atta cephalotes
ACEP23430
I
0.890
ENSONIG00000020610
Oreochromis niloticus
ENSONIG00000020610
I
0.890
EFV58362
Trichinella spiralis
EFV58362
I
0.890
ENSXMAG00000019787
Xiphophorus maculatus
ENSXMAG00000019787
I
0.890
TMUE_s0004013100
Trichuris muris
TMUE_s0004013100
I
0.890
D918_07072
Trichuris suis
D918_07072
I
0.890
ENSPFOG00000019887
Poecilia formosa
ENSPFOG00000019887
I
0.890
ENSPFOG00000020053
Poecilia formosa
ENSPFOG00000020053
I
0.890
twist1a
Danio rerio
ENSDARG00000030402
I
0.890
TTRE_0000397101
Trichuris trichiura
TTRE_0000397101
I
0.890
TWIST1
Tetraodon nigroviridis
ENSTNIG00000001678
I
0.890
twist1
Takifugu rubripes
ENSTRUG00000015797
I
0.890
twist1b
Danio rerio
ENSDARG00000076010
I
0.890
TWIST1
Gasterosteus aculeatus
ENSGACG00000006420
I
0.890
twist1b
Tetraodon nigroviridis
ENSTNIG00000018440
I
0.890
twist3
Gasterosteus aculeatus
ENSGACG00000007963
I
0.883
ENSAMXG00000025039
Astyanax mexicanus
ENSAMXG00000025039
I
0.883
twist3b
Gasterosteus aculeatus
ENSGACG00000004773
I
0.883
ENSACAG00000015086
Anolis carolinensis
ENSACAG00000015086
I
0.883
twist3
Oryzias latipes
ENSORLG00000016373
I
0.883
ENSLOCG00000018198
Lepisosteus oculatus
ENSLOCG00000018198
I
0.883
ENSGMOG00000003155
Gadus morhua
ENSGMOG00000003155
I
0.883
ENSPFOG00000020501
Poecilia formosa
ENSPFOG00000020501
I
0.883
twist3
Takifugu rubripes
ENSTRUG00000011374
I
0.883
ENSXMAG00000019956
Xiphophorus maculatus
ENSXMAG00000019956
I
0.883
twist3
Danio rerio
ENSDARG00000019646
I
0.883
twist2
Xenopus tropicalis
XB-GENE-5878700
I
0.883
ENSONIG00000021177
Oreochromis niloticus
ENSONIG00000021177
I
0.883
HelroG155122
Helobdella robusta
HelroG155122
I
0.880
ENSAMXG00000024993
Astyanax mexicanus
ENSAMXG00000024993
I
0.879
CGI_10013641
Crassostrea gigas
CGI_10013641
I
0.879
twist1
Xenopus tropicalis
XB-GENE-479802
I
0.879
twist2
Oryzias latipes
ENSORLG00000018096
I
0.879
ENSXMAG00000020062
Xiphophorus maculatus
ENSXMAG00000020062
I
0.879
twist2
Danio rerio
ENSDARG00000078266
I
0.879
twist2
Takifugu rubripes
ENSTRUG00000006090
I
0.879
twist2
Tetraodon nigroviridis
ENSTNIG00000001562
I
0.879
ENSPFOG00000020314
Poecilia formosa
ENSPFOG00000020314
I
0.879
Hsal_01530--NP_001011637.1_APIME
Harpegnathos saltator
Hsal_01530--NP_001011637.1_APIME
I
0.879
ENSONIG00000021420
Oreochromis niloticus
ENSONIG00000021420
I
0.879
ENSONIG00000021342
Oreochromis niloticus
ENSONIG00000021342
I
0.879
NV10141
Nasonia vitripennis
NV10141
I
0.879
twist2
Gasterosteus aculeatus
ENSGACG00000002227
I
0.879
ISCW009433
Ixodes scapularis
ISCW009433
I
0.879
GB40416
Apis mellifera
GB40416
I
0.879
twist1.S
Xenopus laevis
XB-GENE-865309
I
0.879
twist1.L
Xenopus laevis
XB-GENE-6255840
I
0.879
Twist2
Dipodomys ordii
ENSDORG00000005906
I
0.874
BGIBMGA008990
Bombyx mori
BGIBMGA008990
I
0.873
KGM_08280
Danaus plexippus
KGM_08280
I
0.873
HMEL011603
Heliconius melpomene
HMEL011603
I
0.873
nRc.2.0.1.g46228
Romanomermis culicivorax
nRc.2.0.1.g46228
I
0.870
Gfo_R014393
Geospiza fortis
Gfo_R014393
I
0.870
ENSTGUG00000003756
Taeniopygia guttata
ENSTGUG00000003756
I
0.870
ENSFALG00000015081
Ficedula albicollis
ENSFALG00000015081
I
0.870
SMU15037660
Schmidtea mediterranea
SMU15037660
I
0.870
twi
Drosophila melanogaster
FBgn0003900
D
0.859
csin110283
Clonorchis sinensis
csin110283
I
0.859
MDOA005417
Musca domestica
MDOA005417
I
0.859
twi
Drosophila erecta
FBgn0064598
I
0.859
twi
Drosophila virilis
FBgn0020065
I
0.859
twi
Drosophila simulans
FBgn0016355
I
0.859
DILT_0001206901
Diphyllobothrium latum
DILT_0001206901
I
0.859
A_07561
Schistosoma haematobium
A_07561
I
0.859
EmuJ_000663800
Echinococcus multilocularis
EmuJ_000663800
I
0.859
SSLN_0000059301
Schistocephalus solidus
SSLN_0000059301
I
0.859
TASK_0000180901
Taenia asiatica
TASK_0000180901
I
0.859
TsM_000716700
Taenia solium
TsM_000716700
I
0.859
MCOS_0000111401
Mesocestoides corti
MCOS_0000111401
I
0.859
HNAJ_0000179601
Hymenolepis nana
HNAJ_0000179601
I
0.859
ECPE_0000551801
Echinostoma caproni
ECPE_0000551801
I
0.859
HDID_0001003601
Hymenolepis diminuta
HDID_0001003601
I
0.859
HmN_000912800
Hymenolepis microstoma
HmN_000912800
I
0.859
ECANG7_02703
Echinococcus canadensis
ECANG7_02703
I
0.859
twi
Drosophila yakuba
FBgn0084444
I
0.859
GK19547
Drosophila willistoni
FBgn0221545
I
0.859
GM15978
Drosophila sechellia
FBgn0170894
I
0.859
GI21307
Drosophila mojavensis
FBgn0144037
I
0.859
Sjc_0042560
Schistosoma japonicum
Sjc_0042560
I
0.859
LCUP006189
Lucilia cuprina
LCUP006189
I
0.859
SPU_030059
Strongylocentrotus purpuratus
SPU_030059
I
0.859
Smp_203270
Schistosoma mansoni
Smp_203270
I
0.859
twi
Drosophila pseudoobscura
FBgn0243556
I
0.859
GH20971
Drosophila grimshawi
FBgn0128433
I
0.859
GL11229
Drosophila persimilis
FBgn0148838
I
0.859
GF13559
Drosophila ananassae
FBgn0090588
I
0.859
LotgiG179182
Lottia gigantea
LotgiG179182
I
0.858
BGLB010605
Biomphalaria glabrata
BGLB010605
I
0.855
LLOJ002131
Lutzomyia longipalpis
LLOJ002131
I
0.855
tetur03g03150
Tetranychus urticae
tetur03g03150
I
0.849
ADIR004364
Anopheles dirus
ADIR004364
I
0.847
AEPI000695
Anopheles epiroticus
AEPI000695
I
0.847
CPIJ012828
Culex quinquefasciatus
CPIJ012828
I
0.847
CPIJ012827
Culex quinquefasciatus
CPIJ012827
I
0.847
CpipJ_CPIJ012827
Culex pipiens
CpipJ_CPIJ012827
I
0.847
AARA000771
Anopheles arabiensis
AARA000771
I
0.847
AFUN009694
Anopheles funestus
AFUN009694
I
0.847
CpipJ_CPIJ012828
Culex pipiens
CpipJ_CPIJ012828
I
0.847
AQUA008654
Anopheles quadriannulatus
AQUA008654
I
0.847
AALB010655
Anopheles albimanus
AALB010655
I
0.847
AMIN004405
Anopheles minimus
AMIN004405
I
0.847
ACUA022223
Anopheles culicifacies
ACUA022223
I
0.847
AMEM016167
Anopheles merus
AMEM016167
I
0.847
ACHR006076
Anopheles christyi
ACHR006076
I
0.847
PPAI002101
Phlebotomus papatasi
PPAI002101
I
0.844
NEMVEDRAFT_v1g234699
Nematostella vectensis
NEMVEDRAFT_v1g234699
I
0.844
Gfo_R002785
Geospiza fortis
Gfo_R002785
I
0.777
ENSMMUP00000014629
Macaca fascicularis
ENSMMUP00000014629
I
0.468