| NCBI Gene Info:Enables Notch binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including dauer exit; germ cell development; and regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in Z1.ppp; Z4.aaa; and ventral uterine precursor. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to several human genes including RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022] |