NKX2-2 (Cavia porcellus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSCPOG00000000408 T208067_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.867 1.000
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.867 1.000
NKX2-2
M10681_2.00 		Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01 		0.867 1.000
NKX2-2
M10682_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01 		0.867 1.000
NKX2-2
M10683_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3 		0.867 1.000
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.850 0.965
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.850 0.965
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.850 0.965
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.850 0.965
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.850 0.965
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.843 0.912
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.843 0.912
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.843 0.912
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.811 0.912
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.811 0.912
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.811 0.912
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.811 0.912
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.811 0.912
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.811 0.912
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.811 0.895
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.807 0.860
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.799 0.895
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.798 0.895
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.798 0.895
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.798 0.895
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.798 0.895
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.798 0.895
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.798 0.895
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.798 0.895
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.798 0.895
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.798 0.895
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.784 0.825
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.742 0.789
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.742 0.789
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.742 0.789
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.742 0.789
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.742 0.789
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.742 0.789
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.742 0.789
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.742 0.789
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.742 0.789
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.742 0.789
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.742 0.789
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.742 0.789
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.742 0.789
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.742 0.789
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.742 0.772
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.742 0.772
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.741 0.807
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.741 0.807
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.741 0.807
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.737 0.772
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.736 0.649
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.718 0.754
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.718 0.632
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.718 0.632
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.718 0.632
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.718 0.632
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.718 0.632
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.718 0.632
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.709 0.772
Q24782_9CNID
M02206_2.00 		Eleutheria dichotoma
TTAATTAA
TTAATTAA		 PBM
Weirauch et al.(2014)
pTH5486 		0.613 0.491
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSCPOP00000000359 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Cavia porcellus TFs

821 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Alligator_sinensis_CCG015253.1 Alligator sinensis Alligator_sinensis_CCG015253.1 I
Brh_R004046 Buceros rhinoceros Brh_R004046 I
Cmyd_10010656 Chelonia mydas Cmyd_10010656 I
ENSACAG00000017046 Anolis carolinensis ENSACAG00000017046 I
ENSAMEG00000012594 Ailuropoda melanoleuca ENSAMEG00000012594 I
ENSAMEG00000019057 Ailuropoda melanoleuca ENSAMEG00000019057 I
ENSAMXG00000011388 Astyanax mexicanus ENSAMXG00000011388 I
ENSBTAP00000025739-D1 Bos grunniens ENSBTAP00000025739-D1 I
ENSCPOG00000008197 Cavia porcellus ENSCPOG00000008197 I
ENSCPOG00000024157 Cavia porcellus ENSCPOG00000024157 I
ENSCSAG00000000466 Chlorocebus sabaeus ENSCSAG00000000466 I
ENSCSAG00000006504 Chlorocebus sabaeus ENSCSAG00000006504 I
ENSDNOG00000043562 Dasypus novemcinctus ENSDNOG00000043562 I
ENSFALG00000015243 Ficedula albicollis ENSFALG00000015243 I
ENSLOCG00000007669 Lepisosteus oculatus ENSLOCG00000007669 I
ENSLOCG00000017967 Lepisosteus oculatus ENSLOCG00000017967 I
ENSMICG00000001720 Microcebus murinus ENSMICG00000001720 I
ENSMPUG00000004316 Mustela putorius furo ENSMPUG00000004316 I
ENSNLEG00000013010 Nomascus leucogenys ENSNLEG00000013010 I
ENSNLEG00000018969 Nomascus leucogenys ENSNLEG00000018969 I
ENSOARG00000003039 Ovis aries ENSOARG00000003039 I
ENSOARG00000009454 Ovis aries ENSOARG00000009454 I
ENSONIG00000018071 Oreochromis niloticus ENSONIG00000018071 I
ENSP00000334547 Macaca fascicularis ENSP00000334547 I
ENSP00000334547-D1 Bos grunniens ENSP00000334547-D1 I
ENSPANG00000014670 Papio anubis ENSPANG00000014670 I
ENSPANG00000017357 Papio anubis ENSPANG00000017357 I
ENSPFOG00000013394 Poecilia formosa ENSPFOG00000013394 I
ENSPMAG00000002259 Petromyzon marinus ENSPMAG00000002259 I
ENSPPYG00000009621 Pongo abelii ENSPPYG00000009621 I
ENSPSIG00000000318 Pelodiscus sinensis ENSPSIG00000000318 I
ENSSSCG00000013743 Sus scrofa ENSSSCG00000013743 I
ENSSTOG00000026950 Ictidomys tridecemlineatus ENSSTOG00000026950 I
ENSSTOG00000028401 Ictidomys tridecemlineatus ENSSTOG00000028401 I
ENSTGUG00000006333 Taeniopygia guttata ENSTGUG00000006333 I
ENSTGUG00000018537 Taeniopygia guttata ENSTGUG00000018537 I
ENSTRUG00000004487 Takifugu rubripes ENSTRUG00000004487 I
ENSTSYG00000009754 Tarsius syrichta ENSTSYG00000009754 I
ENSXMAG00000007215 Xiphophorus maculatus ENSXMAG00000007215 I
Gfo_R006237 Geospiza fortis Gfo_R006237 I
LYL1 Pteropus vampyrus ENSPVAG00000015075 I
Lyl1 Rattus norvegicus ENSRNOG00000002950 I
LYL1 Procavia capensis ENSPCAG00000003676 I
LYL1 Tursiops truncatus ENSTTRG00000006376 I
LYL1 Otolemur garnettii ENSOGAG00000033339 I
LYL1 Homo sapiens ENSG00000104903 D
LYL1 Ornithorhynchus anatinus ENSOANG00000006846 I
lyl1 Xenopus tropicalis XB-GENE-940268 I
LYL1 Gorilla gorilla ENSGGOG00000023512 I
LYL1 Loxodonta africana ENSLAFG00000005235 I
Lyl1 Mus musculus ENSMUSG00000034041 D
LYL1 Myotis lucifugus ENSMLUG00000012805 I
LYL1 Bos taurus ENSBTAG00000019329 I
LYL1 Macaca mulatta ENSMMUG00000001166 I
Myotis_brandtii_LYL1_10009227 Myotis brandtii Myotis_brandtii_LYL1_10009227 I
Ogr06402 Ophisaurus gracilis Ogr06402 I
Ogr15798 Ophisaurus gracilis Ogr15798 I
Pvit_09175 Pogona vitticeps Pvit_09175 I
Pvit_14582 Pogona vitticeps Pvit_14582 I
tal1 Tetraodon nigroviridis ENSTNIG00000006133 I
tal1 Oryzias latipes ENSORLG00000003776 I
tal1 Gasterosteus aculeatus ENSGACG00000019476 I
TAL2 Bos taurus ENSBTAG00000045852 I
tal2 Xenopus tropicalis XB-GENE-965184 I
TAL2 Canis familiaris ENSCAFG00000032112 I
TAL2 Callithrix jacchus ENSCJAG00000022534 I
TAL2 Tursiops truncatus ENSTTRG00000003494 I
TAL2 Monodelphis domestica ENSMODG00000022957 I
TAL2 Homo sapiens ENSG00000186051 I
TAL2 Gallus gallus ENSGALG00000023114 I
TAL2 Gorilla gorilla ENSGGOG00000006780 I
TAL2 Loxodonta africana ENSLAFG00000008309 I
TAL2 Felis catus ENSFCAG00000008052 I
TAL2 Echinops telfairi ENSETEG00000007386 I
TAL2 Erinaceus europaeus ENSEEUG00000003187 I
TAL2 Myotis lucifugus ENSMLUG00000008792 I
TAL2 Macaca mulatta ENSMMUG00000002671 I
TAL2 Pteropus vampyrus ENSPVAG00000005744 I
TAL2 Equus caballus ENSECAG00000004995 I
Tal2 Mus musculus ENSMUSG00000028417 I
Tal2 Dipodomys ordii ENSDORG00000012882 I
TAL2 Dasypus novemcinctus ENSDNOG00000006670 I
TAL2 Ornithorhynchus anatinus ENSOANG00000004194 I
TAL2 Anolis carolinensis ENSACAG00000004545 I
TAL2 Otolemur garnettii ENSOGAG00000009225 I
TAL2 Ochotona princeps ENSOPRG00000013838 I
TAL2 Procavia capensis ENSPCAG00000004449 I
TAL2 Pan troglodytes ENSPTRG00000021225 I
Tal_R009538 Tyto alba Tal_R009538 I