NCBI Gene Info:Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Is expressed in several structures, including body wall musculature; dopaminergic neurons; intestine; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; breast cancer (multiple); carcinoma (multiple); osteochondrodysplasia (multiple); and pancreatic cancer. Orthologous to several human genes including RUNX2 (RUNX family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022] |