CpipJ_CPIJ006847 (Culex pipiens)
AT hook

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02178 (AT_hook) IPR017956 CpipJ_CPIJ006847 T017187_2.00 Broad (2016-May-1)

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
BRADI5G22430
M01674_2.00 		Brachypodium distachyon
VNRDDDHDD
HHDHHHYNB		 PBM
Weirauch et al.(2014)
pTH9242 		0.991 0.615
Ahctf1
M00750_2.00 		Mus musculus
AAAWAWAW
ATWTWTTT		 PBM
Weirauch et al.(2013)
pTH2361 		0.991 0.615
Xrp1
M01686_2.00 		Drosophila melanogaster
NNNNDWAWW
WWTWHNNNN		 PBM
Weirauch et al.(2014)
pTH9260 		0.991 0.615
estExt_fgeneshNG_pg.C_820014
M01692_2.00 		Naegleria gruberi
NNNNNDRH
DYHNNNNN		 PBM
Weirauch et al.(2014)
pTH9380 		0.991 0.615
PK26376.1
M01108_2.00 		Cannabis sativa
DDWWWAWW
WWTWWWHH		 PBM
Lambert et al.(2019)
pTH11261 		0.991 0.615
Xrp1
M05900_2.00 		Drosophila melanogaster
RTKRYGYAAT
ATTRCRYMAY		 B1H
Zhu et al.(2011)
Xrp1_CG6272_SANGER_5_FBgn0261113 		0.991 0.615
ATEG_07399
M01676_2.00 		Aspergillus terreus
DHNNHNDWWW
WWWHNDNNDH		 PBM
Weirauch et al.(2014)
pTH9237 		0.991 0.538
ENSACAG00000014978
M01677_2.00 		Anolis carolinensis
NNNNNDRH
DYHNNNNN		 PBM
Weirauch et al.(2014)
pTH9222 		0.991 0.538
phf21ab
M01678_2.00 		Danio rerio
NNNDNADW
WHTNHNNN		 PBM
Weirauch et al.(2014)
pTH9254 		0.991 0.538
kmt2cb
M01679_2.00 		Danio rerio
WWAWAWAT
ATWTWTWW		 PBM
Weirauch et al.(2014)
pTH7876 		0.991 0.538
phf21ab
M01680_2.00 		Gasterosteus aculeatus
AAAAWAAA
TTTWTTTT		 PBM
Weirauch et al.(2014)
pTH9180 		0.991 0.538
PHF21A
M01681_2.00 		Meleagris gallopavo
HDNHNNDNHD
HDNHNNDNHD		 PBM
Weirauch et al.(2014)
pTH7875 		0.991 0.538
PHF21A
M01103_2.00 		Monodelphis domestica
NNNAWATWAATN
NATTWATWTNNN		 PBM
Lambert et al.(2019)
pTH9309 		0.991 0.538
PHF21A
M01682_2.00 		Monodelphis domestica
NNNNNHRH
DYDNNNNN		 PBM
Weirauch et al.(2014)
pTH9335 		0.991 0.538
Phf21a
M01684_2.00 		Mus musculus
NNNATATWAATN
NATTWATATNNN		 PBM
Weirauch et al.(2014)
pTH8550 		0.991 0.538
MTR_4g101990
M01687_2.00 		Medicago truncatula
AAAWTAAT
ATTAWTTT		 PBM
Weirauch et al.(2014)
pTH9209 		0.991 0.538
PK00377.1
M01107_2.00 		Cannabis sativa
DAWWWAWW
WWTWWWTH		 PBM
Lambert et al.(2019)
pTH11338 		0.991 0.538
SUM1
M01517_2.00 		Saccharomyces cerevisiae
NNNDWAWW
WWTWHNNN		 PBM
Zhu et al.(2009)
Sum1 		0.991 0.500
Setbp1
M01683_2.00 		Mus musculus
NDNNNNNNHN
NDNNNNNNHN		 PBM
Weirauch et al.(2014)
pTH1294 		0.991 0.462
TVAG_474020
M01106_2.00 		Trichomonas vaginalis
DNWWWAWW
WWTWWWNH		 PBM
Lambert et al.(2019)
pTH11493 		0.991 0.346
SUM1
M00008_2.00 		Saccharomyces cerevisiae
NNDWWWH
DWWWHNN		 PBM
Badis et al.(2008)
SUM1_2124 		0.991 0.292
FGRRES_17512
M01105_2.00 		Fusarium graminearum
NNNDNWWWW
WWWWNHNNN		 PBM
Lambert et al.(2019)
pTH11412 		0.991 0.280
VIT_08s0007g04020
M01689_2.00 		Vitis vinifera
DBNDDDDDDN
NHHHHHHNVH		 PBM
Weirauch et al.(2014)
pTH9295 		0.991 0.280
AHL13
M01672_2.00 		Arabidopsis thaliana
NAWWTAWWWN
NWWWTAWWTN		 PBM
Weirauch et al.(2014)
pTH8202 		0.991 0.269
BRADI3G55950
M01673_2.00 		Brachypodium distachyon
NNNNRHDDN
NHHDYNNNN		 PBM
Weirauch et al.(2014)
pTH9369 		0.991 0.269
OS02G0824300
M01688_2.00 		Oryza sativa
NNDWAWWN
NWWTWHNN		 PBM
Weirauch et al.(2014)
pTH8406 		0.991 0.269
SUM1
M07439_2.00 		Saccharomyces cerevisiae
DWAAATWWN
NWWATTTWH		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0398.1 		0.991 0.269
SUM1
M08478_2.00 		Saccharomyces cerevisiae
RYGWCASWAAW
WTTWSTGWCRY		 Misc
DeBoer et al.(2011)
YDR310C_383 		0.991 0.269
SUM1
M08479_2.00 		Saccharomyces cerevisiae
DWAAATWWN
NWWATTTWH		 Misc
DeBoer et al.(2011)
YDR310C_478 		0.991 0.269
Q7DLU9_PEA
M09772_2.00 		Pisum sativum Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
P$HMGIY_01 		0.991 0.231
ANIA_01690
M01675_2.00 		Aspergillus nidulans
NNNNRHDDN
NHHDYNNNN		 PBM
Weirauch et al.(2014)
pTH8216 		0.991 0.216
ENSPPYG00000004736
M01685_2.00 		Pongo abelii
NNNNDWWW
WWWHNNNN		 PBM
Weirauch et al.(2014)
pTH9279 		0.991 0.184
NCU05635
M01694_2.00 		Neurospora crassa
NNNWWWWNNN
NNNWWWWNNN		 PBM
Weirauch et al.(2014)
pTH8863 		0.991 0.184
Hmga2
M00751_2.00 		Mus musculus
NNNNRHWWNN
NNWWDYNNNN		 PBM
Weirauch et al.(2013)
pTH3046 		0.991 0.179
HMGA2
M09771_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HMGA2_01 		0.991 0.179
HMGA1
M09769_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HMGIY_01 		0.991 0.179
HMGA1
M09770_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HMGIY_Q4 		0.991 0.179
FGRRES_05233
M01104_2.00 		Fusarium graminearum
NNNDWWAWWH
DWWTWWHNNN		 PBM
Lambert et al.(2019)
pTH11377 		0.991 0.154
NCU01145
M01693_2.00 		Neurospora crassa
RWATAWWTNN
NNAWWTATWY		 PBM
Weirauch et al.(2014)
pTH8916 		0.991 0.129
HMGA
M01671_2.00 		Arabidopsis thaliana
NNNNDWAWH
DWTWHNNNN		 PBM
Weirauch et al.(2014)
pTH7395 		0.991 0.115
HMG-I Y
M02652_2.00 		Pisum sativum
NDWVAAANRVMRWMAY
RTKWYKBYNTTTBWHN		 SELEX
Mathelier et al.(2014)
MA0045.1 		0.991 0.115
athp-3
M01691_2.00 		Caenorhabditis elegans
NNDDWDH
DHWHHNN		 PBM
Weirauch et al.(2014)
pTH9097 		0.991 0.113
hmg-12
M01690_2.00 		Caenorhabditis elegans
NNAWWTAWWTNN
NNAWWTAWWTNN		 PBM
Weirauch et al.(2014)
pTH8997 		0.991 0.074
For this family, TFs with SR scores > 0.990 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
CpipJ_CPIJ006847-RA AT hook 484 496

Links

Other AT hook family TFs
Other Culex pipiens TFs

1072 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ACYPI001448 Acyrthosiphon pisum ACYPI001448 I
AAEL002902 Aedes aegypti AAEL002902 I
ENSAMEG00000008556 Ailuropoda melanoleuca ENSAMEG00000008556 I
ENSAMEG00000020165 Ailuropoda melanoleuca ENSAMEG00000020165 I
Alligator_sinensis_CCG002585.1 Alligator sinensis Alligator_sinensis_CCG002585.1 I
Alligator_sinensis_CCG008488.1 Alligator sinensis Alligator_sinensis_CCG008488.1 I
ENSAPLG00000000878 Anas platyrhynchos ENSAPLG00000000878 I
ENSAPLG00000007177 Anas platyrhynchos ENSAPLG00000007177 I
ENSACAG00000009715 Anolis carolinensis ENSACAG00000009715 I
twist1 Anolis carolinensis ENSACAG00000011825 I
ENSACAG00000015086 Anolis carolinensis ENSACAG00000015086 I
AATE005140 Anopheles atroparvus AATE005140 I
ACOM023427 Anopheles coluzzii ACOM023427 I
AFAF020800 Anopheles farauti AFAF020800 I
AGAP011985 Anopheles gambiae AGAP011985 I
AMEC000330 Anopheles melas AMEC000330 I
ASTEI05879 Anopheles stephensi ASTEI05879 I
GB40416 Apis mellifera GB40416 I
Afo_R010658 Aptenodytes forsteri Afo_R010658 I
Afo_R013292 Aptenodytes forsteri Afo_R013292 I
ENSAMXG00000024993 Astyanax mexicanus ENSAMXG00000024993 I
ENSAMXG00000025039 Astyanax mexicanus ENSAMXG00000025039 I
ENSAMXG00000025095 Astyanax mexicanus ENSAMXG00000025095 I
ENSAMXG00000025610 Astyanax mexicanus ENSAMXG00000025610 I
ENSAMXG00000025657 Astyanax mexicanus ENSAMXG00000025657 I
ACEP23430 Atta cephalotes ACEP23430 I
BGLB003400 Biomphalaria glabrata BGLB003400 I
BGIBMGA008990 Bombyx mori BGIBMGA008990 I
ENSP00000405176-D1 Bos grunniens ENSP00000405176-D1 I
TWIST2 Bos taurus ENSBTAG00000021444 I
TWIST1 Bos taurus ENSBTAG00000046922 I
estExt_gwp.C_4170045 Branchiostoma floridae estExt_gwp.C_4170045 I
fgenesh2_pm.scaffold_217000008 Branchiostoma floridae fgenesh2_pm.scaffold_217000008 I
Brh_R012765 Buceros rhinoceros Brh_R012765 I
TWIST2 Callithrix jacchus ENSCJAG00000023006 I
Aan_R001044 Calypte anna Aan_R001044 I
Aan_R002857 Calypte anna Aan_R002857 I
Cflo_04586--NP_001011637.1_APIME Camponotus floridanus Cflo_04586--NP_001011637.1_APIME I
TWIST2 Canis familiaris ENSCAFG00000012469 I
CapteG111042 Capitella teleta CapteG111042 I
CapteG154829 Capitella teleta CapteG154829 I
TWIST2 Cavia porcellus ENSCPOG00000025980 I
Cmyd_10002489 Chelonia mydas Cmyd_10002489 I
Cmyd_10006750 Chelonia mydas Cmyd_10006750 I
ENSCSAG00000018801 Chlorocebus sabaeus ENSCSAG00000018801 I
ENSCSAG00000019610 Chlorocebus sabaeus ENSCSAG00000019610 I
CLEC011700 Cimex lectularius CLEC011700 I
csin110283 Clonorchis sinensis csin110283 I
CGI_10006631 Crassostrea gigas CGI_10006631 I
CGI_10013641 Crassostrea gigas CGI_10013641 I
KGM_08280 Danaus plexippus KGM_08280 I
twist3 Danio rerio ENSDARG00000019646 I
twist1a Danio rerio ENSDARG00000030402 I
twist1b Danio rerio ENSDARG00000076010 I
twist2 Danio rerio ENSDARG00000078266 I
DAPPUDRAFT_320202 Daphnia pulex DAPPUDRAFT_320202 I
TWIST2 Dasypus novemcinctus ENSDNOG00000002434 I
TWIST1 Dasypus novemcinctus ENSDNOG00000037354 I
YQE_04855 Dendroctonus ponderosae YQE_04855 I
DILT_0001206901 Diphyllobothrium latum DILT_0001206901 I
Twist2 Dipodomys ordii ENSDORG00000005906 I
ENSDORG00000012866 Dipodomys ordii ENSDORG00000012866 I
GF13559 Drosophila ananassae FBgn0090588 I
twi Drosophila erecta FBgn0064598 I
GH20971 Drosophila grimshawi FBgn0128433 I
twi Drosophila melanogaster FBgn0003900 D
GI21307 Drosophila mojavensis FBgn0144037 I
GL11229 Drosophila persimilis FBgn0148838 I
twi Drosophila pseudoobscura FBgn0243556 I
GM15978 Drosophila sechellia FBgn0170894 I
twi Drosophila simulans FBgn0016355 I
twi Drosophila virilis FBgn0020065 I
GK19547 Drosophila willistoni FBgn0221545 I
twi Drosophila yakuba FBgn0084444 I
ECANG7_02703 Echinococcus canadensis ECANG7_02703 I
EmuJ_000663800 Echinococcus multilocularis EmuJ_000663800 I
TWIST2 Echinops telfairi ENSETEG00000009809 I
ENSETEG00000013115 Echinops telfairi ENSETEG00000013115 I
ECPE_0000551801 Echinostoma caproni ECPE_0000551801 I
TWIST1 Erinaceus europaeus ENSEEUG00000015333 I
ENSFALG00000009781 Ficedula albicollis ENSFALG00000009781 I
ENSFALG00000014990 Ficedula albicollis ENSFALG00000014990 I
ENSFALG00000015081 Ficedula albicollis ENSFALG00000015081 I
ENSGMOG00000002790 Gadus morhua ENSGMOG00000002790 I
ENSGMOG00000003155 Gadus morhua ENSGMOG00000003155 I
ENSGALG00000004274 Gallus gallus ENSGALG00000004274 I
ENSGALG00000006321 Gallus gallus ENSGALG00000006321 I
ENSGALG00000026059 Gallus gallus ENSGALG00000026059 I
twist2 Gasterosteus aculeatus ENSGACG00000002227 I
twist3b Gasterosteus aculeatus ENSGACG00000004773 I
TWIST1 Gasterosteus aculeatus ENSGACG00000006420 I
twist3 Gasterosteus aculeatus ENSGACG00000007963 I
twist1b Gasterosteus aculeatus ENSGACG00000008070 I
Gfo_R012065 Geospiza fortis Gfo_R012065 I
Gfo_R014393 Geospiza fortis Gfo_R014393 I
Hsal_01530--NP_001011637.1_APIME Harpegnathos saltator Hsal_01530--NP_001011637.1_APIME I
HMEL011603 Heliconius melpomene HMEL011603 I
HelroG155122 Helobdella robusta HelroG155122 I
TWIST1 Homo sapiens ENSG00000122691 D
TWIST2 Homo sapiens ENSG00000233608 I
HDID_0001003601 Hymenolepis diminuta HDID_0001003601 I
HmN_000912800 Hymenolepis microstoma HmN_000912800 I
HNAJ_0000179601 Hymenolepis nana HNAJ_0000179601 I
ENSSTOG00000004633 Ictidomys tridecemlineatus ENSSTOG00000004633 I
ISCW009433 Ixodes scapularis ISCW009433 I
ENSLACG00000012096 Latimeria chalumnae ENSLACG00000012096 I
ENSLACG00000013366 Latimeria chalumnae ENSLACG00000013366 I
ENSLACG00000019113 Latimeria chalumnae ENSLACG00000019113 I
ENSLOCG00000017835 Lepisosteus oculatus ENSLOCG00000017835 I
ENSLOCG00000018198 Lepisosteus oculatus ENSLOCG00000018198 I
ENSLOCG00000018350 Lepisosteus oculatus ENSLOCG00000018350 I
LDEC006528 Leptinotarsa decemlineata LDEC006528 I
LotgiG126724 Lottia gigantea LotgiG126724 N
LotgiG179182 Lottia gigantea LotgiG179182 I
TWIST2 Loxodonta africana ENSLAFG00000032174 I
LCUP006189 Lucilia cuprina LCUP006189 I
TWIST1 Macaca mulatta ENSMMUG00000011173 I
TWIST2 Macaca mulatta ENSMMUG00000021909 I
ENSMEUG00000013853 Macropus eugenii ENSMEUG00000013853 I
ENSMGAG00000002218 Meleagris gallopavo ENSMGAG00000002218 I
TWIST1 Meleagris gallopavo ENSMGAG00000009311 I
MCOS_0000111401 Mesocestoides corti MCOS_0000111401 I
ENSMODG00000001412 Monodelphis domestica ENSMODG00000001412 I
TWIST1 Monodelphis domestica ENSMODG00000023924 I
MDOA005417 Musca domestica MDOA005417 I
ENSMPUG00000019429 Mustela putorius furo ENSMPUG00000019429 I
Twist2 Mus musculus ENSMUSG00000007805 D
Twist1 Mus musculus ENSMUSG00000035799 D
Myotis_brandtii_Twist1_10031742 Myotis brandtii Myotis_brandtii_Twist1_10031742 I
TWIST1 Myotis lucifugus ENSMLUG00000007047 I
TWIST2 Myotis lucifugus ENSMLUG00000023316 I
NV10141 Nasonia vitripennis NV10141 I
ENSNLEG00000011342 Nomascus leucogenys ENSNLEG00000011342 I
ENSNLEG00000019264 Nomascus leucogenys ENSNLEG00000019264 I
TWIST2 Ochotona princeps ENSOPRG00000017069 I
Ocbimv22015922m.g Octopus bimaculoides Ocbimv22015922m.g I
Ogr01719 Ophisaurus gracilis Ogr01719 I
Ogr06591 Ophisaurus gracilis Ogr06591 I
Ogr11552 Ophisaurus gracilis Ogr11552 I
Ogr11553 Ophisaurus gracilis Ogr11553 I
ENSONIG00000020502 Oreochromis niloticus ENSONIG00000020502 I
ENSONIG00000020610 Oreochromis niloticus ENSONIG00000020610 I
ENSONIG00000021177 Oreochromis niloticus ENSONIG00000021177 I
ENSONIG00000021342 Oreochromis niloticus ENSONIG00000021342 I
ENSONIG00000021420 Oreochromis niloticus ENSONIG00000021420 I
TWIST1 Ornithorhynchus anatinus ENSOANG00000009614 I
ENSOANG00000012950 Ornithorhynchus anatinus ENSOANG00000012950 I
TWIST2 Oryctolagus cuniculus ENSOCUG00000004073 I
TWIST1 Oryzias latipes ENSORLG00000004012 I
twist1 Oryzias latipes ENSORLG00000007251 I
twist3 Oryzias latipes ENSORLG00000016373 I
twist2 Oryzias latipes ENSORLG00000018096 I
TWIST2 Otolemur garnettii ENSOGAG00000029007 I
ENSOARG00000000265 Ovis aries ENSOARG00000000265 I
ENSOARG00000009754 Ovis aries ENSOARG00000009754 I
ENSPTRG00000018960 Pan troglodytes ENSPTRG00000018960 I
TWIST2 Pan troglodytes ENSPTRG00000033910 I
ENSPANG00000001578 Papio anubis ENSPANG00000001578 I
PHUM396880 Pediculus humanus PHUM396880 I
ENSPSIG00000001961 Pelodiscus sinensis ENSPSIG00000001961 I
ENSPSIG00000012843 Pelodiscus sinensis ENSPSIG00000012843 I
ENSPMAG00000003993 Petromyzon marinus ENSPMAG00000003993 I
ENSPMAG00000010126 Petromyzon marinus ENSPMAG00000010126 I
ENSPFOG00000019887 Poecilia formosa ENSPFOG00000019887 I
ENSPFOG00000020053 Poecilia formosa ENSPFOG00000020053 I
ENSPFOG00000020314 Poecilia formosa ENSPFOG00000020314 I
ENSPFOG00000020501 Poecilia formosa ENSPFOG00000020501 I
Pvit_02271 Pogona vitticeps Pvit_02271 I
Pvit_05844 Pogona vitticeps Pvit_05844 I
ENSPPYG00000017754 Pongo abelii ENSPPYG00000017754 I
TWIST1 Pteropus vampyrus ENSPVAG00000001710 I
Twist1 Rattus norvegicus ENSRNOG00000011101 I
Twist2 Rattus norvegicus ENSRNOG00000020355 I
RPRC000323 Rhodnius prolixus RPRC000323 I
nRc.2.0.1.g46228 Romanomermis culicivorax nRc.2.0.1.g46228 I
Sakowv30001350m.g Saccoglossus kowalevskii Sakowv30001350m.g I
ENSSHAG00000003328 Sarcophilus harrisii ENSSHAG00000003328 I
SSLN_0000059301 Schistocephalus solidus SSLN_0000059301 I
A_07561 Schistosoma haematobium A_07561 I
Sjc_0042560 Schistosoma japonicum Sjc_0042560 I
Smp_203270 Schistosoma mansoni Smp_203270 I
SMU15037660 Schmidtea mediterranea SMU15037660 I
SINV20920 Solenopsis invicta SINV20920 I
SPU_030059 Strongylocentrotus purpuratus SPU_030059 I
TWIST1 Sus scrofa ENSSSCG00000015370 I
TWIST2 Sus scrofa ENSSSCG00000016343 I
TASK_0000180901 Taenia asiatica TASK_0000180901 I
TsM_000716700 Taenia solium TsM_000716700 I
TWIST1 Taeniopygia guttata ENSTGUG00000002643 I
ENSTGUG00000003194 Taeniopygia guttata ENSTGUG00000003194 I
ENSTGUG00000003756 Taeniopygia guttata ENSTGUG00000003756 I
twist2 Takifugu rubripes ENSTRUG00000006090 I
twist3 Takifugu rubripes ENSTRUG00000011374 I
twist3 Takifugu rubripes ENSTRUG00000012607 I
twist1 Takifugu rubripes ENSTRUG00000015797 I
twist3 Tetraodon nigroviridis ENSTNIG00000000441 I
twist2 Tetraodon nigroviridis ENSTNIG00000001562 I
TWIST1 Tetraodon nigroviridis ENSTNIG00000001678 I
twist1b Tetraodon nigroviridis ENSTNIG00000018440 I
TC014598 Tribolium castaneum TC014598 I
D917_00468 Trichinella nativa D917_00468 I
EFV58362 Trichinella spiralis EFV58362 I
TMUE_s0004013100 Trichuris muris TMUE_s0004013100 I
D918_07072 Trichuris suis D918_07072 I
TTRE_0000397101 Trichuris trichiura TTRE_0000397101 I
twist1.L Xenopus laevis XB-GENE-6255840 I
twist1.S Xenopus laevis XB-GENE-865309 I
twist1 Xenopus tropicalis XB-GENE-479802 I
twist2 Xenopus tropicalis XB-GENE-5878700 I
ENSXMAG00000019787 Xiphophorus maculatus ENSXMAG00000019787 I
ENSXMAG00000019956 Xiphophorus maculatus ENSXMAG00000019956 I
ENSXMAG00000019999 Xiphophorus maculatus ENSXMAG00000019999 I
ENSXMAG00000020062 Xiphophorus maculatus ENSXMAG00000020062 I
ENSXMAG00000020142 Xiphophorus maculatus ENSXMAG00000020142 I
L798_05856 Zootermopsis nevadensis L798_05856 I