CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HES2
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000069812
T034248_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HES2
M04060_2.00
Homo sapiens
VRCACGTGCC
GGCACGTGYB
SELEX
Yin et al.(2017)
HES2_eDBD_HT-SELEX
(Direct)
(Direct)
HES2
M04061_2.00
Homo sapiens
VNHVYVYNVN
NBNRBRBDNB
SELEX
Yin et al.(2017)
HES2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000367065
bHLH
14
71
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELP
ENSP00000367067
bHLH
14
73
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGREDASGWHTWLPLHAQNCFLLYIQAPEQ
ENSP00000367068
bHLH
14
73
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGREDASGWHTWLPLHAQNCFLLYIQAPEQ
ENSP00000465248
bHLH
14
58
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRECLATATARATA
ENSP00000465270
bHLH
14
71
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELP
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
12 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy