HES2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000069812 T034248_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HES2
M04060_2.00		 Homo sapiens
VRCACGTGCC
GGCACGTGYB		 SELEX
Yin et al.(2017)
HES2_eDBD_HT-SELEX		 (Direct) (Direct)
HES2
M04061_2.00		 Homo sapiens
VNHVYVYNVN
NBNRBRBDNB		 SELEX
Yin et al.(2017)
HES2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000367065 bHLH 14 71
ENSP00000367067 bHLH 14 73
ENSP00000367068 bHLH 14 73
ENSP00000465248 bHLH 14 58
ENSP00000465270 bHLH 14 71

Links

Other bHLH family TFs
Other Homo sapiens TFs

12 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000004187 Papio anubis ENSPANG00000004187 I 0.914
ENSPPYG00000001944 Pongo abelii ENSPPYG00000001944 I 0.914
HES2 Pan troglodytes ENSPTRG00000000085 N 0.914
HES2 Callithrix jacchus ENSCJAG00000000166 I 0.914
HES2 Macaca mulatta ENSMMUG00000022882 I 0.914
HES2 Gorilla gorilla ENSGGOG00000001846 I 0.914
ENSCSAG00000000740 Chlorocebus sabaeus ENSCSAG00000000740 I 0.914
ENSSTOG00000013642 Ictidomys tridecemlineatus ENSSTOG00000013642 I 0.866
ENSCPOG00000024138 Cavia porcellus ENSCPOG00000024138 I 0.866
HES2 Otolemur garnettii ENSOGAG00000024214 I 0.866
ENSTBEG00000011892 Tupaia belangeri ENSTBEG00000011892 I 0.842