CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Figla
(
Mus musculus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSMUSG00000030001
T035701_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in follicle cell of primary follicle; oocyte of primary follicle; oocyte of secondary follicle; and ovary. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 6. Orthologous to human FIGLA (folliculogenesis specific bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Figla
M01737_2.00
Mus musculus
NNCASSTGN
NCASSTGNN
PBM
Weirauch et al.(2014)
pTH5105
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
FIGLA
M02805_2.00
Homo sapiens
HMCACCTGKN
NMCAGGTGKD
SELEX
Jolma et al.(2013)
FIGLA_1
0.890
0.923
FIGLA
M04205_2.00
Homo sapiens
HMCACCTGB
VCAGGTGKD
SELEX
Yin et al.(2017)
FIGLA_eDBD_HT-SELEX
0.890
0.923
FIGLA
M04206_2.00
Homo sapiens
HMCACCTGK
MCAGGTGKD
SELEX
Yin et al.(2017)
FIGLA_eDBD_Methyl-HT-SELEX
0.890
0.923
For this family, TFs with SR scores >
0.838
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M01737_2.00
bHLH
15
67
RRRVANAKERERIKNLNRGFAKLKALVPFLPQSKKPSKVDILKGATEYIQILG
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000032070
bHLH
60
112
RRRVANAKERERIKNLNRGFAKLKALVPFLPQSKKPSKVDILKGATEYIQILG
Links
Other
bHLH
family TFs
Other
Mus musculus
TFs
26 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy