CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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E(spl)mbeta-HLH
(
Drosophila melanogaster
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
FBgn0002733
T038398_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuroblast proliferation. Located in nucleus. Is expressed in several structures, including extended germ band embryo; germ layer; gut section; presumptive embryonic/larval system; and thoracic segment. Orthologous to several human genes including HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
E(spl)mbeta-HLH
M03597_2.00
Drosophila melanogaster
HGGCACGTGCCR
YGGCACGTGCCD
SELEX
Nitta et al.(2015)
HLHmbeta_1
(Direct)
(Direct)
E(spl)mbeta-HLH
M05945_2.00
Drosophila melanogaster
CRCGTGCC
GGCACGYG
B1H
Zhu et al.(2011)
HLHmbeta_SANGER_10_FBgn0002733
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
E(spl)m3-HLH
M03596_2.00
Drosophila melanogaster
DTGGCACGTGCCAH
DTGGCACGTGCCAH
SELEX
Nitta et al.(2015)
HLHm3_1
0.890
0.873
E(spl)m3-HLH
M05939_2.00
Drosophila melanogaster
CACGTGVCA
TGBCACGTG
B1H
Zhu et al.(2011)
HLHm3_SANGER_5_FBgn0002609
0.890
0.873
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0084355
bHLH
14
71
RKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLR
Links
Other
bHLH
family TFs
Other
Drosophila melanogaster
TFs
30 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy