CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
Home
Tools
View cart
Bulk downloads
Database stats
Contact us
Help
Update Log
FAQ
Links
How to cite
E(spl)mbeta-HLH
(
Drosophila melanogaster
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
FBgn0002733
T038398_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuroblast proliferation. Located in nucleus. Is expressed in several structures, including extended germ band embryo; germ layer; gut section; presumptive embryonic/larval system; and thoracic segment. Orthologous to several human genes including HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
E(spl)mbeta-HLH
M03597_2.00
Drosophila melanogaster
HGGCACGTGCCR
YGGCACGTGCCD
SELEX
Nitta et al.(2015)
HLHmbeta_1
(Direct)
(Direct)
E(spl)mbeta-HLH
M05945_2.00
Drosophila melanogaster
CRCGTGCC
GGCACGYG
B1H
Zhu et al.(2011)
HLHmbeta_SANGER_10_FBgn0002733
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
E(spl)m3-HLH
M03596_2.00
Drosophila melanogaster
DTGGCACGTGCCAH
DTGGCACGTGCCAH
SELEX
Nitta et al.(2015)
HLHm3_1
0.890
0.873
E(spl)m3-HLH
M05939_2.00
Drosophila melanogaster
CACGTGVCA
TGBCACGTG
B1H
Zhu et al.(2011)
HLHm3_SANGER_5_FBgn0002609
0.890
0.873
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0084355
bHLH
14
71
RKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLR
Links
Other
bHLH
family TFs
Other
Drosophila melanogaster
TFs
30 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
GI22910
Drosophila mojavensis
FBgn0145637
I
0.914
GH18148
Drosophila grimshawi
FBgn0125616
I
0.914
GL22021
Drosophila persimilis
FBgn0159614
I
0.914
GM10206
Drosophila sechellia
FBgn0165157
I
0.914
GJ23323
Drosophila virilis
FBgn0210424
I
0.914
GK12809
Drosophila willistoni
FBgn0214818
I
0.914
LCUP008810
Lucilia cuprina
LCUP008810
I
0.914
GG12207
Drosophila erecta
FBgn0104499
I
0.914
HLHmbeta
Drosophila simulans
FBgn0082739
I
0.914
GF18225
Drosophila ananassae
FBgn0095243
I
0.914
HLHmbeta
Drosophila yakuba
FBgn0082707
I
0.914
MDOA014216
Musca domestica
MDOA014216
I
0.914
GA13073
Drosophila pseudoobscura
FBgn0073111
I
0.914
MDOA002768
Musca domestica
MDOA002768
I
0.890
GE23647
Drosophila yakuba
FBgn0240814
I
0.890
GJ23906
Drosophila virilis
FBgn0210999
I
0.890
LCUP008813
Lucilia cuprina
LCUP008813
I
0.890
MESCA005144
Megaselia scalaris
MESCA005144
I
0.890
GK14458
Drosophila willistoni
FBgn0216464
I
0.890
GL21819
Drosophila persimilis
FBgn0159412
I
0.890
GH19456
Drosophila grimshawi
FBgn0126921
I
0.890
GG11454
Drosophila erecta
FBgn0103753
I
0.890
GF16799
Drosophila ananassae
FBgn0093820
I
0.890
GM10297
Drosophila sechellia
FBgn0165248
I
0.890
GA21008
Drosophila pseudoobscura
FBgn0080997
I
0.890
E(spl)m3-HLH
Drosophila melanogaster
FBgn0002609
D
0.890
GI24690
Drosophila mojavensis
FBgn0147412
I
0.890
HLHm3
Drosophila simulans
FBgn0082736
I
0.890
L798_10928
Zootermopsis nevadensis
L798_10928
I
0.844
L798_10924
Zootermopsis nevadensis
L798_10924
I
0.844