CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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mdl-1
(
Caenorhabditis elegans
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
WBGene00003163
T046295_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan and regulation of cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including intestine; neurons; pharynx; somatic gonad precursor; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to several human genes including MXD3 (MAX dimerization protein 3) and MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
mdl-1
M08183_2.00
Caenorhabditis elegans
CACGTGAY
RTCACGTG
ChIP-seq
Contrino et al.(2012)
Mw156
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
R03E9.1
bHLH
96
148
SRTAHNELEKTRRANLRGCLETLKMLVPCVSDATRNTTLALLTRARDHIIELQ
Links
Other
bHLH
family TFs
Other
Caenorhabditis elegans
TFs
8 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy