mdl-1 (Caenorhabditis elegans)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 WBGene00003163 T046295_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan and regulation of cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including intestine; neurons; pharynx; somatic gonad precursor; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to several human genes including MXD3 (MAX dimerization protein 3) and MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
mdl-1
M08183_2.00		 Caenorhabditis elegans
CACGTGAY
RTCACGTG		 ChIP-seq
Contrino et al.(2012)
Mw156		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
R03E9.1 bHLH 96 148

Links

Other bHLH family TFs
Other Caenorhabditis elegans TFs

8 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBG10881 Caenorhabditis briggsae CBG10881 I 0.914
CJA08920 Caenorhabditis japonica CJA08920 I 0.914
CBN24539 Caenorhabditis brenneri CBN24539 I 0.914
TELCIR_11825 Teladorsagia circumcincta TELCIR_11825 I 0.860
HPLM_0001847601 Haemonchus placei HPLM_0001847601 I 0.860
ACAC_0000575701 Angiostrongylus cantonensis ACAC_0000575701 I 0.860
DICVIV_06590 Dictyocaulus viviparus DICVIV_06590 I 0.860
HCOI00642400 Haemonchus contortus HCOI00642400 I 0.860