NKX2-6 (Equus caballus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSECAG00000013714 T209138_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.819 0.895
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.819 0.895
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.819 0.895
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.819 0.895
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.819 0.895
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.819 0.895
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.819 0.895
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.819 0.860
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.819 0.860
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.819 0.860
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.819 0.860
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.819 0.860
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.819 0.860
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.819 0.860
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.819 0.860
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.819 0.860
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.819 0.860
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.819 0.860
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.819 0.860
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.819 0.860
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.819 0.860
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.819 0.842
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.819 0.842
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.814 0.842
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.794 0.737
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.788 0.895
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.786 0.842
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.774 0.807
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.769 0.754
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.759 0.684
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.759 0.684
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.759 0.684
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.759 0.684
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.759 0.684
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.759 0.684
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.753 0.789
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.753 0.789
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.753 0.789
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.753 0.789
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.753 0.789
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.753 0.789
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.753 0.789
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.753 0.789
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.753 0.789
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.716 0.772
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.716 0.772
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.716 0.772
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.708 0.754
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.708 0.754
NKX2-2
M10681_2.00 		Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01 		0.708 0.754
NKX2-2
M10682_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01 		0.708 0.754
NKX2-2
M10683_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3 		0.708 0.754
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.708 0.737
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.708 0.737
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.708 0.737
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.708 0.737
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.708 0.737
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.684 0.754
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.684 0.754
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.684 0.754
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.684 0.754
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.684 0.754
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.684 0.754
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.684 0.737
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.677 0.667
ENSCING00000007395
M02076_2.00 		Ciona intestinalis
NNNDWNWR
YWNWHNNN		 PBM
Weirauch et al.(2014)
pTH5922 		0.617 0.667
Nkx3-1
M00170_2.00 		Mus musculus
NDAAGTRBNN
NNVYACTTHN		 PBM
Badis et al.(2009)
Nkx3-1_2923 		0.610 0.684
Nkx3-1
M00420_2.00 		Mus musculus
NNAAGTRBNN
NNVYACTTNN		 PBM
Berger et al.(2008)
Nkx3-1_2923 		0.610 0.684
NKX3-1
M05255_2.00 		Homo sapiens
NNTAAGTGSN
NSCACTTANN		 SELEX
Yin et al.(2017)
NKX3-1_eDBD_HT-SELEX 		0.610 0.684
NKX3-1
M09154_2.00 		Homo sapiens
NYDAAGTGBYWD
HWRVCACTTHRN		 Misc
Kulakovskiy et al.(2013)
NKX31_HUMAN.H11MO.0.C 		0.610 0.684
Nkx3-1
M09184_2.00 		Mus musculus
NYDAAGTGBYWD
HWRVCACTTHRN		 Misc
Kulakovskiy et al.(2013)
NKX31_MOUSE.H11MO.0.C 		0.610 0.684
NKX3-1
M09559_2.00 		Homo sapiens
BTRAGTRBYY
RRVYACTYAV		 Misc
Heinz et al.(2010)
LNCaP-Nkx3.1_GSE28264 		0.610 0.684
NKX3-1
M10729_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
P$GT1_Q6_01 		0.610 0.684
NKX3-1
M10730_2.00 		Homo sapiens
NWWTAAGTATWH
DWATACTTAWWN		 Transfac
Matys et al.(2006)
V$NKX3A_01 		0.610 0.684
NKX3-1
M10731_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX3A_Q3 		0.610 0.684
NKX3-1
M05256_2.00 		Homo sapiens
NNTAAGTGBN
NVCACTTANN		 SELEX
Yin et al.(2017)
NKX3-1_eDBD_Methyl-HT-SELEX_1 		0.610 0.684
NKX3-1
M05257_2.00 		Homo sapiens
NTAAYSWB
VWSRTTAN		 SELEX
Yin et al.(2017)
NKX3-1_eDBD_Methyl-HT-SELEX_2 		0.610 0.684
Nkx3-2
M00506_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Bapx1_2343 		0.605 0.702
NKX3-2
M05012_2.00 		Homo sapiens
NNTAAGTGSN
NSCACTTANN		 SELEX
Yin et al.(2017)
NKX3-2_eDBD_HT-SELEX 		0.605 0.702
NKX3-2
M09138_2.00 		Homo sapiens
TTAAGTGBNH
DNVCACTTAA		 Misc
Kulakovskiy et al.(2013)
NKX32_HUMAN.H11MO.0.C 		0.605 0.702
Nkx3-2
M09212_2.00 		Mus musculus
TTAAGTGBNH
DNVCACTTAA		 Misc
Kulakovskiy et al.(2013)
NKX32_MOUSE.H11MO.0.B 		0.605 0.702
NKX3-2
M10663_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX32_01 		0.605 0.702
NKX3-2
M05013_2.00 		Homo sapiens
NNTAAGTGBN
NVCACTTANN		 SELEX
Yin et al.(2017)
NKX3-2_eDBD_Methyl-HT-SELEX_1 		0.605 0.702
NKX3-2
M05014_2.00 		Homo sapiens
NTAACGHB
VDCGTTAN		 SELEX
Yin et al.(2017)
NKX3-2_eDBD_Methyl-HT-SELEX_2 		0.605 0.702
bap
M00560_2.00 		Drosophila melanogaster
NDAAGTRBNN
NNVYACTTHN		 PBM
Busser et al.(2012a)
Bap 		0.605 0.702
bap
M02119_2.00 		Drosophila melanogaster
NYTAAGTRSNN
NNSYACTTARN		 PBM
Weirauch et al.(2014)
pTH5945 		0.605 0.702
bap
M03812_2.00 		Drosophila melanogaster
NNTAAGTGBN
NVCACTTANN		 SELEX
Nitta et al.(2015)
bap_1 		0.605 0.702
bap
M06504_2.00 		Drosophila melanogaster
TTAAGTR
YACTTAA		 B1H
Mathelier et al.(2014)
MA0211.1 		0.605 0.702
bap
M06287_2.00 		Drosophila melanogaster
NBTTAAGTRN
NYACTTAAVN		 B1H
Zhu et al.(2011)
Bap_Cell_FBgn0004862 		0.605 0.702
bap
M06288_2.00 		Drosophila melanogaster
NYTAAKTR
YAMTTARN		 B1H
Zhu et al.(2011)
Bap_SOLEXA_FBgn0004862 		0.605 0.702
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSECAP00000011392 Homeodomain 131 187

Links

Other Homeodomain family TFs
Other Equus caballus TFs

979 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ACRE_069230 Acremonium chrysogenum ACRE_069230 N 0.000
MCYG_08710 Arthroderma otae MCYG_08710 N 0.000
ACLA_088930 Aspergillus clavatus CADACLAG00008857 N 0.000
COCC4DRAFT_64454 Bipolaris maydis COCC4DRAFT_64454 N 0.000
BDDG_07110 Blastomyces dermatitidis BDDG_07110 N 0.000
CHGG_00926 Chaetomium globosum CHGG_00926 N 0.000
CH063_13215 Colletotrichum higginsianum CH063_13215 N 0.000
HCBG_05651 Histoplasma capsulatum HCBG_05651 N 0.000
MPH_11049 Macrophomina phaseolina MPH_11049 N 0.000
MCYG_08710 Microsporum canis MCYG_08710 N 0.000
PEX1_051210 Penicillium expansum PEX1_051210 N 0.000
PITC_016440 Penicillium italicum PITC_016440 N 0.000
SAPIO_CDS3191 Scedosporium apiospermum SAPIO_CDS3191 N 0.000
SBOR_2893 Sclerotinia borealis SBOR_2893 N 0.000
S40285_04043 Stachybotrys chlorohalonata S40285_04043 N 0.000
TSTA_058560 Talaromyces stipitatus TSTA_058560 N 0.000