CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Nfkb1
(
Rattus norvegicus
)
Rel
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00554 (RHD_DNA_bind)
IPR011539
ENSRNOG00000023258
T317480_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
NFKB1
M03448_2.00
Homo sapiens
MGGGGAWTCCCCT
AGGGGAWTCCCCK
SELEX
Jolma et al.(2013)
NFKB1_1
0.994
0.994
NFKB1
M05887_2.00
Homo sapiens
NGGKRNTYYCCCN
NGGGRRANYMCCN
SMiLE-seq
Isakova et al.(2017)
NFKB1
0.994
0.994
NFKB1
M09348_2.00
Homo sapiens
HYTTCCCY
RGGGAARD
Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A
0.994
0.994
NFKB1
M11228_2.00
Homo sapiens
GGGGATYCCC
GGGRATCCCC
Transfac
Matys et al.(2006)
V$NFKAPPAB50_01
0.994
0.994
NFKB1
M11229_2.00
Homo sapiens
NGGGAHTYYCCM
KGGRRADTCCCN
Transfac
Matys et al.(2006)
V$NFKB_C
0.994
0.994
NFKB1
M11230_2.00
Homo sapiens
DKGGGAMTTYCCNN
NNGGRAAKTCCCMH
Transfac
Matys et al.(2006)
V$NFKB_Q6
0.994
0.994
NFKB1
M11231_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P50_Q6
0.994
0.994
Nfkb1
M09358_2.00
Mus musculus
GGGRNTTYCCC
GGGRAANYCCC
Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A
0.988
0.988
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000028944
Rel
43
241
LQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEGGGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDS
Links
Other
Rel
family TFs
Other
Rattus norvegicus
TFs
65 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy