Nfkb1 (Mus musculus)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSMUSG00000028163 T317316_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in JNK cascade; cellular response to virus; and negative regulation of cytokine production. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nfkb1
M09358_2.00		 Mus musculus
GGGRNTTYCCC
GGGRAANYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFKB1
M03448_2.00 		Homo sapiens
MGGGGAWTCCCCT
AGGGGAWTCCCCK		 SELEX
Jolma et al.(2013)
NFKB1_1 		0.857 0.857
NFKB1
M05887_2.00 		Homo sapiens
NGGKRNTYYCCCN
NGGGRRANYMCCN		 SMiLE-seq
Isakova et al.(2017)
NFKB1 		0.857 0.857
NFKB1
M09348_2.00 		Homo sapiens
HYTTCCCY
RGGGAARD		 Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A 		0.857 0.857
NFKB1
M11228_2.00 		Homo sapiens
GGGGATYCCC
GGGRATCCCC		 Transfac
Matys et al.(2006)
V$NFKAPPAB50_01 		0.982 0.982
NFKB1
M11229_2.00 		Homo sapiens
NGGGAHTYYCCM
KGGRRADTCCCN		 Transfac
Matys et al.(2006)
V$NFKB_C 		0.982 0.982
NFKB1
M11230_2.00 		Homo sapiens
DKGGGAMTTYCCNN
NNGGRAAKTCCCMH		 Transfac
Matys et al.(2006)
V$NFKB_Q6 		0.982 0.982
NFKB1
M11231_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P50_Q6 		0.982 0.982
NFKB2
M03446_2.00 		Homo sapiens
NGGGGAWTCCCCB
VGGGGAWTCCCCN		 SELEX
Jolma et al.(2013)
NFKB2_1 		0.714 0.714
NFKB2
M05699_2.00 		Homo sapiens
HGGKRNWTCCCCN
NGGGGAWNYMCCD		 SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX 		0.714 0.714
NFKB2
M09344_2.00 		Homo sapiens
GGGRHTTYCCC
GGGRAADYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B 		0.714 0.714
Nfkb2
M09356_2.00 		Mus musculus
GGGRHTTYCCC
GGGRAADYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C 		0.714 0.714
NFKB2
M05700_2.00 		Homo sapiens
HGGKRNWTYCCCN
NGGGRAWNYMCCD		 SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX 		0.714 0.714
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000029812 Rel 42 240
ENSMUSP00000128345 Rel 42 240
ENSMUSP00000143601 Rel 42 90

Links

Other Rel family TFs
Other Mus musculus TFs

91 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
NFKB1 Sus scrofa ENSSSCG00000030957 I 1.000
NFKB1 Bos taurus ENSBTAG00000020270 I 0.994
ENSBTAP00000027016-D1 Bos grunniens ENSBTAP00000027016-D1 I 0.994
ENSOARG00000012718 Ovis aries ENSOARG00000012718 I 0.994
NFKB1 Tursiops truncatus ENSTTRG00000010852 I 0.988
Nfkb1 Rattus norvegicus ENSRNOG00000023258 I 0.988
NFKB1 Pteropus vampyrus ENSPVAG00000002722 I 0.988
NFKB1 Canis familiaris ENSCAFG00000010730 I 0.988
ENSMPUG00000009413 Mustela putorius furo ENSMPUG00000009413 I 0.988
NFKB1 Tupaia belangeri ENSTBEG00000003520 I 0.988
NFKB1 Vicugna pacos ENSVPAG00000000280 I 0.988
ENSAMEG00000008882 Ailuropoda melanoleuca ENSAMEG00000008882 I 0.988
NFKB1 Loxodonta africana ENSLAFG00000009344 I 0.982
NFKB1 Felis catus ENSFCAG00000007557 I 0.982
NFKB1 Homo sapiens ENSG00000109320 D 0.982
NFKB1 Gorilla gorilla ENSGGOG00000009071 I 0.982
ENSP00000226574 Macaca fascicularis ENSP00000226574 I 0.982
ENSCSAG00000004049 Chlorocebus sabaeus ENSCSAG00000004049 I 0.982
NFKB1 Cavia porcellus ENSCPOG00000007789 I 0.982
NFKB1 Pan troglodytes ENSPTRG00000016320 I 0.982
ENSSTOG00000011445 Ictidomys tridecemlineatus ENSSTOG00000011445 I 0.982
NFKB1 Macaca mulatta ENSMMUG00000003736 I 0.982
ENSNLEG00000013325 Nomascus leucogenys ENSNLEG00000013325 I 0.982
NFKB1 Dasypus novemcinctus ENSDNOG00000006855 I 0.982
NFKB1 Monodelphis domestica ENSMODG00000020672 I 0.976
NFKB1 Callithrix jacchus ENSCJAG00000015382 I 0.976
ENSPPYG00000014965 Pongo abelii ENSPPYG00000014965 I 0.976
NFKB1 Otolemur garnettii ENSOGAG00000012840 I 0.976
Nfkb1 Dipodomys ordii ENSDORG00000007447 I 0.970
ENSSHAG00000007374 Sarcophilus harrisii ENSSHAG00000007374 I 0.970
NFKB1 Myotis lucifugus ENSMLUG00000005986 I 0.965
NFKB1 Oryctolagus cuniculus ENSOCUG00000021712 I 0.965
ENSMEUG00000001334 Macropus eugenii ENSMEUG00000001334 I 0.965
Myotis_brandtii_NFKB1_10013135 Myotis brandtii Myotis_brandtii_NFKB1_10013135 I 0.965
NFKB1 Ochotona princeps ENSOPRG00000005212 I 0.965
NFKB1 Procavia capensis ENSPCAG00000008172 I 0.953
ENSPANG00000023882 Papio anubis ENSPANG00000023882 I 0.941
Brh_R011794 Buceros rhinoceros Brh_R011794 I 0.929
NFKB1 Meleagris gallopavo ENSMGAG00000011299 I 0.929
ENSFALG00000008136 Ficedula albicollis ENSFALG00000008136 I 0.929
Tal_R004861 Tyto alba Tal_R004861 I 0.929
NFKB1 Gallus gallus ENSGALG00000012304 I 0.929
ENSAPLG00000013878 Anas platyrhynchos ENSAPLG00000013878 I 0.929
Gfo_R000994 Geospiza fortis Gfo_R000994 I 0.923
Afo_R015662 Aptenodytes forsteri Afo_R015662 I 0.923
Aan_R012729 Calypte anna Aan_R012729 I 0.923
NFKB1 Taeniopygia guttata ENSTGUG00000003595 I 0.917
Alligator_sinensis_CCG005309.1 Alligator sinensis Alligator_sinensis_CCG005309.1 I 0.911
ENSPSIG00000008515 Pelodiscus sinensis ENSPSIG00000008515 I 0.911
NFKB1 Equus caballus ENSECAG00000015042 I 0.911
NFKB2 Homo sapiens ENSG00000077150 D 0.897
Pvit_05196 Pogona vitticeps Pvit_05196 I 0.893
ENSOANG00000028755 Ornithorhynchus anatinus ENSOANG00000028755 I 0.872
Ogr10707 Ophisaurus gracilis Ogr10707 I 0.852
NFKB1 Choloepus hoffmanni ENSCHOG00000010814 N 0.837
nfkb1 Xenopus tropicalis XB-GENE-985746 I 0.805
ENSLACG00000002751 Latimeria chalumnae ENSLACG00000002751 I 0.796
nfkb1 Danio rerio ENSDARG00000105261 I 0.776
ENSXMAG00000015369 Xiphophorus maculatus ENSXMAG00000015369 I 0.776
nfkb1.L Xenopus laevis XB-GENE-985749 I 0.775
ENSLOCG00000012080 Lepisosteus oculatus ENSLOCG00000012080 I 0.751
Aan_R011824 Calypte anna Aan_R011824 I 0.735
ENSAMXG00000003341 Astyanax mexicanus ENSAMXG00000003341 I 0.728
Cmyd_10006544 Chelonia mydas Cmyd_10006544 I 0.714
Myotis_brandtii_NFKB2_10025917 Myotis brandtii Myotis_brandtii_NFKB2_10025917 I 0.714
ENSBTAP00000007904-D1 Bos grunniens ENSBTAP00000007904-D1 I 0.714
Brh_R009664 Buceros rhinoceros Brh_R009664 I 0.714
Ogr18048 Ophisaurus gracilis Ogr18048 I 0.714
ENSOARG00000000483 Ovis aries ENSOARG00000000483 I 0.714
NFKB2 Dasypus novemcinctus ENSDNOG00000032784 I 0.714
Nfkb2 Dipodomys ordii ENSDORG00000013409 I 0.714
NFKB2 Equus caballus ENSECAG00000019593 I 0.714
NFKB2 Felis catus ENSFCAG00000001242 I 0.714
NFKB2 Cavia porcellus ENSCPOG00000004847 I 0.714
NFKB2 Callithrix jacchus ENSCJAG00000017928 I 0.714
ENSAMEG00000017735 Ailuropoda melanoleuca ENSAMEG00000017735 I 0.714
NFKB2 Bos taurus ENSBTAG00000006017 I 0.714
NFKB2 Canis familiaris ENSCAFG00000010155 I 0.714
ENSLACG00000016308 Latimeria chalumnae ENSLACG00000016308 N 0.714
NFKB2 Myotis lucifugus ENSMLUG00000006287 I 0.714
NFKB2 Ochotona princeps ENSOPRG00000006569 I 0.714
Nfkb2 Rattus norvegicus ENSRNOG00000019311 I 0.714
NFKB2 Sus scrofa ENSSSCG00000010580 I 0.714
ENSSTOG00000002191 Ictidomys tridecemlineatus ENSSTOG00000002191 I 0.714
NFKB2 Otolemur garnettii ENSOGAG00000016379 I 0.714
ENSMPUG00000016882 Mustela putorius furo ENSMPUG00000016882 I 0.714
NFKB2 Anolis carolinensis ENSACAG00000014215 I 0.714
Nfkb2 Mus musculus ENSMUSG00000025225 D 0.714
ENSPFOG00000016918 Poecilia formosa ENSPFOG00000016918 I 0.710
ENSONIG00000004349 Oreochromis niloticus ENSONIG00000004349 I 0.704