CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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NFKB2
(
Homo sapiens
)
Rel
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00554 (RHD_DNA_bind)
IPR011539
ENSG00000077150
T317167_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
NFKB2
M03446_2.00
Homo sapiens
NGGGGAWTCCCCB
VGGGGAWTCCCCN
SELEX
Jolma et al.(2013)
NFKB2_1
(Direct)
(Direct)
NFKB2
M05699_2.00
Homo sapiens
HGGKRNWTCCCCN
NGGGGAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX
(Direct)
(Direct)
NFKB2
M05700_2.00
Homo sapiens
HGGKRNWTYCCCN
NGGGRAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
NFKB2
M09344_2.00
Homo sapiens
GGGRHTTYCCC
GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Nfkb2
M09356_2.00
Mus musculus
GGGRHTTYCCC
GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C
1.000
1.000
NFKB1
M03448_2.00
Homo sapiens
MGGGGAWTCCCCT
AGGGGAWTCCCCK
SELEX
Jolma et al.(2013)
NFKB1_1
0.897
0.897
NFKB1
M05887_2.00
Homo sapiens
NGGKRNTYYCCCN
NGGGRRANYMCCN
SMiLE-seq
Isakova et al.(2017)
NFKB1
0.897
0.897
NFKB1
M09348_2.00
Homo sapiens
HYTTCCCY
RGGGAARD
Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A
0.897
0.897
Nfkb1
M09358_2.00
Mus musculus
GGGRNTTYCCC
GGGRAANYCCC
Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A
0.897
0.897
NFKB1
M11228_2.00
Homo sapiens
GGGGATYCCC
GGGRATCCCC
Transfac
Matys et al.(2006)
V$NFKAPPAB50_01
0.897
0.897
NFKB1
M11229_2.00
Homo sapiens
NGGGAHTYYCCM
KGGRRADTCCCN
Transfac
Matys et al.(2006)
V$NFKB_C
0.897
0.897
NFKB1
M11230_2.00
Homo sapiens
DKGGGAMTTYCCNN
NNGGRAAKTCCCMH
Transfac
Matys et al.(2006)
V$NFKB_Q6
0.897
0.897
NFKB1
M11231_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P50_Q6
0.897
0.897
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000189444
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
ENSP00000358983
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
ENSP00000410256
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
ENSP00000471586
Rel
40
68
LVIVEQPKQRGFRFRYGCEGPSHGGLPGA
ENSP00000480211
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
Links
Other
Rel
family TFs
Other
Homo sapiens
TFs
101 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
NFKB2
Felis catus
ENSFCAG00000001242
I
1.000
NFKB2
Macaca mulatta
ENSMMUG00000002990
I
1.000
ENSMPUG00000016882
Mustela putorius furo
ENSMPUG00000016882
I
1.000
NFKB2
Equus caballus
ENSECAG00000019593
I
1.000
Nfkb2
Dipodomys ordii
ENSDORG00000013409
I
1.000
NFKB2
Microcebus murinus
ENSMICG00000011856
I
1.000
NFKB2
Gorilla gorilla
ENSGGOG00000006971
I
1.000
ENSOARG00000000483
Ovis aries
ENSOARG00000000483
I
1.000
NFKB2
Myotis lucifugus
ENSMLUG00000006287
I
1.000
Nfkb2
Mus musculus
ENSMUSG00000025225
D
1.000
ENSSTOG00000002191
Ictidomys tridecemlineatus
ENSSTOG00000002191
I
1.000
ENSNLEG00000015079
Nomascus leucogenys
ENSNLEG00000015079
I
1.000
ENSPPYG00000002599
Pongo abelii
ENSPPYG00000002599
I
1.000
NFKB2
Sus scrofa
ENSSSCG00000010580
I
1.000
NFKB2
Dasypus novemcinctus
ENSDNOG00000032784
I
1.000
NFKB2
Otolemur garnettii
ENSOGAG00000016379
I
1.000
NFKB2
Canis familiaris
ENSCAFG00000010155
I
1.000
Myotis_brandtii_NFKB2_10025917
Myotis brandtii
Myotis_brandtii_NFKB2_10025917
I
1.000
ENSPANG00000021013
Papio anubis
ENSPANG00000021013
I
1.000
NFKB2
Bos taurus
ENSBTAG00000006017
I
1.000
NFKB2
Pan troglodytes
ENSPTRG00000002888
I
1.000
ENSAMEG00000017735
Ailuropoda melanoleuca
ENSAMEG00000017735
I
1.000
NFKB2
Sorex araneus
ENSSARG00000006180
I
1.000
Nfkb2
Rattus norvegicus
ENSRNOG00000019311
I
1.000
ENSCSAG00000005442
Chlorocebus sabaeus
ENSCSAG00000005442
I
1.000
NFKB2
Ochotona princeps
ENSOPRG00000006569
I
1.000
ENSBTAP00000007904-D1
Bos grunniens
ENSBTAP00000007904-D1
I
1.000
NFKB2
Callithrix jacchus
ENSCJAG00000017928
I
1.000
NFKB2
Cavia porcellus
ENSCPOG00000004847
I
1.000
NFKB2
Oryctolagus cuniculus
ENSOCUG00000005735
I
0.976
NFKB1
Gasterosteus aculeatus
ENSGACG00000016876
I
0.966
Aan_R011824
Calypte anna
Aan_R011824
I
0.966
NFKB2
Taeniopygia guttata
ENSTGUG00000007491
I
0.966
ENSLACG00000016308
Latimeria chalumnae
ENSLACG00000016308
N
0.966
Brh_R009664
Buceros rhinoceros
Brh_R009664
I
0.966
Gfo_R002459
Geospiza fortis
Gfo_R002459
I
0.966
ENSP00000189444
Macaca fascicularis
ENSP00000189444
I
0.953
NFKB2
Procavia capensis
ENSPCAG00000011503
I
0.953
NFKB2
Loxodonta africana
ENSLAFG00000006805
I
0.953
ENSSHAG00000018852
Sarcophilus harrisii
ENSSHAG00000018852
I
0.947
ENSMEUG00000011176
Macropus eugenii
ENSMEUG00000011176
I
0.941
NFKB2
Anolis carolinensis
ENSACAG00000014215
I
0.931
ENSGMOG00000007506
Gadus morhua
ENSGMOG00000007506
N
0.931
ENSXMAG00000015369
Xiphophorus maculatus
ENSXMAG00000015369
I
0.931
Ogr18048
Ophisaurus gracilis
Ogr18048
I
0.931
Pvit_13855
Pogona vitticeps
Pvit_13855
I
0.931
ENSLACG00000002751
Latimeria chalumnae
ENSLACG00000002751
I
0.931
nfkb1
Danio rerio
ENSDARG00000105261
I
0.931
Cmyd_10006544
Chelonia mydas
Cmyd_10006544
I
0.931
NFKB2
Echinops telfairi
ENSETEG00000002347
I
0.905
Gfo_R000994
Geospiza fortis
Gfo_R000994
I
0.897
NFKB1
Pteropus vampyrus
ENSPVAG00000002722
I
0.897
ENSPPYG00000014965
Pongo abelii
ENSPPYG00000014965
I
0.897
Tal_R004861
Tyto alba
Tal_R004861
I
0.897
ENSBTAP00000027016-D1
Bos grunniens
ENSBTAP00000027016-D1
I
0.897
ENSSHAG00000007374
Sarcophilus harrisii
ENSSHAG00000007374
I
0.897
NFKB1
Taeniopygia guttata
ENSTGUG00000003595
I
0.897
NFKB1
Tupaia belangeri
ENSTBEG00000003520
I
0.897
NFKB1
Tursiops truncatus
ENSTTRG00000010852
I
0.897
NFKB1
Vicugna pacos
ENSVPAG00000000280
I
0.897
ENSSTOG00000011445
Ictidomys tridecemlineatus
ENSSTOG00000011445
I
0.897
Afo_R015662
Aptenodytes forsteri
Afo_R015662
I
0.897
Nfkb1
Rattus norvegicus
ENSRNOG00000023258
I
0.897
ENSOARG00000012718
Ovis aries
ENSOARG00000012718
I
0.897
NFKB1
Loxodonta africana
ENSLAFG00000009344
I
0.897
NFKB1
Callithrix jacchus
ENSCJAG00000015382
I
0.897
ENSMPUG00000009413
Mustela putorius furo
ENSMPUG00000009413
I
0.897
NFKB1
Bos taurus
ENSBTAG00000020270
I
0.897
NFKB1
Canis familiaris
ENSCAFG00000010730
I
0.897
NFKB1
Equus caballus
ENSECAG00000015042
I
0.897
NFKB1
Felis catus
ENSFCAG00000007557
I
0.897
NFKB1
Choloepus hoffmanni
ENSCHOG00000010814
N
0.897
Nfkb1
Mus musculus
ENSMUSG00000028163
D
0.897
ENSAMEG00000008882
Ailuropoda melanoleuca
ENSAMEG00000008882
I
0.897
NFKB1
Procavia capensis
ENSPCAG00000008172
I
0.897
NFKB1
Otolemur garnettii
ENSOGAG00000012840
I
0.897
NFKB1
Oryctolagus cuniculus
ENSOCUG00000021712
I
0.897
NFKB1
Ochotona princeps
ENSOPRG00000005212
I
0.897
ENSOANG00000030023
Ornithorhynchus anatinus
ENSOANG00000030023
I
0.884
nfkb2
Oryzias latipes
ENSORLG00000002942
N
0.828
ENSPFOG00000012589
Poecilia formosa
ENSPFOG00000012589
N
0.828
nfkb2
Danio rerio
ENSDARG00000038687
N
0.828
nfkb2
Gasterosteus aculeatus
ENSGACG00000001323
N
0.828
ENSPMAG00000006461
Petromyzon marinus
ENSPMAG00000006461
N
0.828
ENSGMOG00000002675
Gadus morhua
ENSGMOG00000002675
N
0.828
ENSONIG00000007023
Oreochromis niloticus
ENSONIG00000007023
N
0.828
nfkb2
Takifugu rubripes
ENSTRUG00000004360
N
0.828
ENSMGAG00000007084
Meleagris gallopavo
ENSMGAG00000007084
I
0.805
Alligator_sinensis_CCG009270.1
Alligator sinensis
Alligator_sinensis_CCG009270.1
I
0.805
ENSFALG00000007271
Ficedula albicollis
ENSFALG00000007271
I
0.805
NFKB2
Gallus gallus
ENSGALG00000005653
I
0.799
ENSAPLG00000013409
Anas platyrhynchos
ENSAPLG00000013409
I
0.793
BGLB002091
Biomphalaria glabrata
BGLB002091
N
0.793
NEMVEDRAFT_v1g174238
Nematostella vectensis
NEMVEDRAFT_v1g174238
N
0.793
ENSLACG00000002526
Latimeria chalumnae
ENSLACG00000002526
N
0.793
Afo_R002575
Aptenodytes forsteri
Afo_R002575
I
0.793
nfkbp105
Ciona intestinalis
ENSCING00000006933
N
0.759
Ocbimv22024030m.g
Octopus bimaculoides
Ocbimv22024030m.g
N
0.759
ENSLOCG00000012593
Lepisosteus oculatus
ENSLOCG00000012593
N
0.759
ENSCSAVG00000003063
Ciona savignyi
ENSCSAVG00000003063
N
0.759