TFEB (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000112561 T034264_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TFEB
M02727_2.00		 Homo sapiens
RTCACGTGAY
RTCACGTGAY		 SELEX
Jolma et al.(2010)
TFEB_dimer		 (Direct) (Direct)
TFEB
M02781_2.00		 Homo sapiens
RNCACGTGAY
RTCACGTGNY		 SELEX
Jolma et al.(2013)
TFEB_1		 (Direct) (Direct)
TFEB
M04088_2.00		 Homo sapiens
YVCACGTGAYN
NRTCACGTGBR		 SELEX
Yin et al.(2017)
TFEB_eDBD_HT-SELEX		 (Direct) (Direct)
TFEB
M04089_2.00		 Homo sapiens
VNCATGTGAYN
NRTCACATGNB		 SELEX
Yin et al.(2017)
TFEB_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
TFEB
M08718_2.00		 Homo sapiens
CACGTGAYY
RRTCACGTG		 Misc
Kulakovskiy et al.(2013)
TFEB_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tfeb
M01728_2.00 		Mus musculus
CWCGTGAY
RTCACGWG		 PBM
Weirauch et al.(2014)
pTH5072 		0.914 1.000
Tfeb
M08753_2.00 		Mus musculus
CACGTGAYY
RRTCACGTG		 Misc
Kulakovskiy et al.(2013)
TFEB_MOUSE.H11MO.0.C 		0.914 1.000
Mitf
M01741_2.00 		Mus musculus
NCDCGTGAYN
NRTCACGHGN		 PBM
Weirauch et al.(2014)
pTH5465 		0.855 0.889
MITF
M08058_2.00 		Homo sapiens
NNNDRTCACGTGAYHNNN
NNNDRTCACGTGAYHNNN		 ChIP-seq
Mathelier et al.(2014)
MA0620.2 		0.855 0.889
MITF
M08740_2.00 		Homo sapiens
YCAYGTGACH
DGTCACRTGR		 Misc
Kulakovskiy et al.(2013)
MITF_HUMAN.H11MO.0.A 		0.855 0.889
Mitf
M08765_2.00 		Mus musculus
BCHYGTGACY
RGTCACRDGV		 Misc
Kulakovskiy et al.(2013)
MITF_MOUSE.H11MO.0.A 		0.855 0.889
Mitf
M09475_2.00 		Mus musculus
GTCACRWGVB
VBCWYGTGAC		 Misc
Heinz et al.(2010)
MastCells-MITF_GSE48085 		0.855 0.889
MITF
M09880_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MITF_Q4 		0.855 0.889
MITF
M09881_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MITF_Q6 		0.855 0.889
Tfe3
M01715_2.00 		Mus musculus
NCDCRTGAYN
NRTCAYGHGN		 PBM
Weirauch et al.(2014)
pTH5057 		0.855 0.870
Tfe3
M05833_2.00 		Mus musculus
CACGTGAY
RTCACGTG		 SMiLE-seq
Isakova et al.(2017)
TFE3 		0.855 0.870
Tfe3
M08743_2.00 		Mus musculus
TCACGTGACH
DGTCACGTGA		 Misc
Kulakovskiy et al.(2013)
TFE3_MOUSE.H11MO.0.A 		0.855 0.870
Tfe3
M09884_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TFEA_01 		0.855 0.870
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000230323 bHLH 236 289
ENSP00000343948 bHLH 322 375
ENSP00000351742 bHLH 250 303
ENSP00000362124 bHLH 236 289
ENSP00000377824 bHLH 236 267
ENSP00000383998 bHLH 94 147
ENSP00000384203 bHLH 236 289
ENSP00000410391 bHLH 236 267
ENSP00000412551 bHLH 151 204

Links

Other bHLH family TFs
Other Homo sapiens TFs

153 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMEG00000013103 Ailuropoda melanoleuca ENSAMEG00000013103 I 0.914
ENSAPLG00000010269 Anas platyrhynchos ENSAPLG00000010269 I 0.914
TFEB Bos taurus ENSBTAG00000012384 I 0.914
TFEB Canis familiaris ENSCAFG00000001599 I 0.914
MITF Choloepus hoffmanni ENSCHOG00000011031 N 0.914
TFEB Callithrix jacchus ENSCJAG00000004199 I 0.914
TFEB Cavia porcellus ENSCPOG00000008027 I 0.914
ENSCSAG00000011274 Chlorocebus sabaeus ENSCSAG00000011274 I 0.914
TFEB Equus caballus ENSECAG00000019762 I 0.914
TFEB Echinops telfairi ENSETEG00000018481 N 0.914
ENSFALG00000003097 Ficedula albicollis ENSFALG00000003097 I 0.914
TFEB Felis catus ENSFCAG00000011521 I 0.914
ENSGALG00000003404 Gallus gallus ENSGALG00000003404 I 0.914
TFEB Gorilla gorilla ENSGGOG00000002683 I 0.914
TFEB Loxodonta africana ENSLAFG00000003059 I 0.914
TFEB Meleagris gallopavo ENSMGAG00000006159 I 0.914
TFEB Microcebus murinus ENSMICG00000015674 I 0.914
TFEB Myotis lucifugus ENSMLUG00000000232 I 0.914
TFEB Macaca mulatta ENSMMUG00000004690 I 0.914
ENSMPUG00000013594 Mustela putorius furo ENSMPUG00000013594 I 0.914
Tfeb Mus musculus ENSMUSG00000023990 D 0.914
ENSNLEG00000004906 Nomascus leucogenys ENSNLEG00000004906 I 0.914
TFEB Ornithorhynchus anatinus ENSOANG00000015438 I 0.914
ENSOARG00000002322 Ovis aries ENSOARG00000002322 I 0.914
TFEB Oryctolagus cuniculus ENSOCUG00000027474 I 0.914
TFEB Otolemur garnettii ENSOGAG00000010116 I 0.914
ENSPANG00000009713 Papio anubis ENSPANG00000009713 I 0.914
ENSPPYG00000016599 Pongo abelii ENSPPYG00000016599 I 0.914
ENSPSIG00000010995 Pelodiscus sinensis ENSPSIG00000010995 I 0.914
TFEB Pan troglodytes ENSPTRG00000018157 I 0.914
TFEB Pteropus vampyrus ENSPVAG00000007581 I 0.914
Tfeb Rattus norvegicus ENSRNOG00000014666 I 0.914
ENSSHAG00000009705 Sarcophilus harrisii ENSSHAG00000009705 I 0.914
TFEB Sus scrofa ENSSSCG00000001621 I 0.914
ENSSTOG00000015338 Ictidomys tridecemlineatus ENSSTOG00000015338 I 0.914
ENSTGUG00000017182 Taeniopygia guttata ENSTGUG00000017182 N 0.914
ENSTGUG00000017433 Taeniopygia guttata ENSTGUG00000017433 I 0.914
ENSTTRG00000016385 Tursiops truncatus ENSTTRG00000016385 I 0.914
Aan_R003797 Calypte anna Aan_R003797 I 0.914
Afo_R002063 Aptenodytes forsteri Afo_R002063 I 0.914
Alligator_sinensis_CCG020422.1 Alligator sinensis Alligator_sinensis_CCG020422.1 I 0.914
Brh_R005039 Buceros rhinoceros Brh_R005039 I 0.914
Cmyd_10010632 Chelonia mydas Cmyd_10010632 I 0.914
ENSP00000343948-D1 Bos grunniens ENSP00000343948-D1 I 0.914
ENSP00000343948 Macaca fascicularis ENSP00000343948 I 0.914
Gfo_R002984 Geospiza fortis Gfo_R002984 I 0.914
Myotis_brandtii_TFEB_10015405 Myotis brandtii Myotis_brandtii_TFEB_10015405 I 0.914
Tal_R006591 Tyto alba Tal_R006591 I 0.914
ENSEEUG00000004984 Erinaceus europaeus ENSEEUG00000004984 N 0.886
e_gw.61.133.1 Branchiostoma floridae e_gw.61.133.1 N 0.884
TFEB Monodelphis domestica ENSMODG00000012916 I 0.882
TFEB Anolis carolinensis ENSACAG00000002664 I 0.871
ENSAMXG00000007343 Astyanax mexicanus ENSAMXG00000007343 I 0.871
tfeb Danio rerio ENSDARG00000010794 I 0.871
ENSLACG00000013218 Latimeria chalumnae ENSLACG00000013218 I 0.871
ENSLOCG00000012145 Lepisosteus oculatus ENSLOCG00000012145 I 0.871
ENSONIG00000019306 Oreochromis niloticus ENSONIG00000019306 I 0.871
ENSPFOG00000017022 Poecilia formosa ENSPFOG00000017022 I 0.871
tfeb Tetraodon nigroviridis ENSTNIG00000007281 I 0.871
tfeb Takifugu rubripes ENSTRUG00000000653 I 0.871
ENSXMAG00000003856 Xiphophorus maculatus ENSXMAG00000003856 I 0.871
Ogr06907 Ophisaurus gracilis Ogr06907 I 0.871
Pvit_06044 Pogona vitticeps Pvit_06044 I 0.871
TFEC Erinaceus europaeus ENSEEUG00000001121 N 0.870
MITF Anolis carolinensis ENSACAG00000013586 I 0.855
TFE3 Anolis carolinensis ENSACAG00000022140 I 0.855
ENSAMEG00000017117 Ailuropoda melanoleuca ENSAMEG00000017117 I 0.855
ENSAPLG00000011965 Anas platyrhynchos ENSAPLG00000011965 I 0.855
MITF Bos taurus ENSBTAG00000006679 I 0.855
MITF Canis familiaris ENSCAFG00000006496 I 0.855
MITF Callithrix jacchus ENSCJAG00000013260 I 0.855
TFE3 Cavia porcellus ENSCPOG00000012410 I 0.855
MITF Cavia porcellus ENSCPOG00000014963 I 0.855
ENSCSAG00000011595 Chlorocebus sabaeus ENSCSAG00000011595 I 0.855
mitfa Danio rerio ENSDARG00000003732 I 0.855
mitfb Danio rerio ENSDARG00000037833 I 0.855
MITF Dasypus novemcinctus ENSDNOG00000037006 I 0.855
Mitf Dipodomys ordii ENSDORG00000003336 I 0.855
ENSDORG00000013258 Dipodomys ordii ENSDORG00000013258 I 0.855
MITF Equus caballus ENSECAG00000005360 I 0.855
MITF Erinaceus europaeus ENSEEUG00000005163 I 0.855
ENSFALG00000013383 Ficedula albicollis ENSFALG00000013383 I 0.855
MITF Felis catus ENSFCAG00000024419 I 0.855
MITF Homo sapiens ENSG00000187098 D 0.855
mitfb Gasterosteus aculeatus ENSGACG00000003425 I 0.855
tfe3b Gasterosteus aculeatus ENSGACG00000010355 I 0.855
mitfa Gasterosteus aculeatus ENSGACG00000011875 I 0.855
ENSGALG00000007679 Gallus gallus ENSGALG00000007679 I 0.855
MITF Gorilla gorilla ENSGGOG00000024338 I 0.855
ENSGMOG00000007421 Gadus morhua ENSGMOG00000007421 I 0.855
ENSGMOG00000010175 Gadus morhua ENSGMOG00000010175 I 0.855
ENSLACG00000011547 Latimeria chalumnae ENSLACG00000011547 I 0.855
MITF Loxodonta africana ENSLAFG00000023153 I 0.855
ENSLOCG00000010058 Lepisosteus oculatus ENSLOCG00000010058 I 0.855
MITF Meleagris gallopavo ENSMGAG00000009507 I 0.855
ENSMICG00000002894 Microcebus murinus ENSMICG00000002894 I 0.855
MITF Myotis lucifugus ENSMLUG00000002587 I 0.855
MITF Macaca mulatta ENSMMUG00000002100 I 0.855
MITF Monodelphis domestica ENSMODG00000003754 I 0.855
ENSMPUG00000016972 Mustela putorius furo ENSMPUG00000016972 I 0.855
Tfe3 Mus musculus ENSMUSG00000000134 D 0.855
Mitf Mus musculus ENSMUSG00000035158 D 0.855
ENSNLEG00000002357 Nomascus leucogenys ENSNLEG00000002357 I 0.855
ENSOANG00000012406 Ornithorhynchus anatinus ENSOANG00000012406 I 0.855
TFE3 Ornithorhynchus anatinus ENSOANG00000013574 I 0.855
ENSOARG00000009833 Ovis aries ENSOARG00000009833 I 0.855
MITF Oryctolagus cuniculus ENSOCUG00000002190 I 0.855
MITF Otolemur garnettii ENSOGAG00000000043 I 0.855
ENSONIG00000016952 Oreochromis niloticus ENSONIG00000016952 I 0.855
ENSONIG00000020270 Oreochromis niloticus ENSONIG00000020270 I 0.855
mitfa Oryzias latipes ENSORLG00000003123 I 0.855
mitfb Oryzias latipes ENSORLG00000013461 I 0.855
ENSPANG00000011565 Papio anubis ENSPANG00000011565 I 0.855
ENSPFOG00000006677 Poecilia formosa ENSPFOG00000006677 I 0.855
ENSPFOG00000007171 Poecilia formosa ENSPFOG00000007171 I 0.855
ENSPMAG00000004927 Petromyzon marinus ENSPMAG00000004927 I 0.855
ENSPPYG00000013725 Pongo abelii ENSPPYG00000013725 I 0.855
ENSPSIG00000012120 Pelodiscus sinensis ENSPSIG00000012120 I 0.855
MITF Pan troglodytes ENSPTRG00000015100 I 0.855
Mitf Rattus norvegicus ENSRNOG00000008658 I 0.855
Tfe3 Rattus norvegicus ENSRNOG00000009605 I 0.855
MITF Sorex araneus ENSSARG00000002538 I 0.855
ENSSHAG00000017522 Sarcophilus harrisii ENSSHAG00000017522 I 0.855
ENSSTOG00000014237 Ictidomys tridecemlineatus ENSSTOG00000014237 I 0.855
MITF Tupaia belangeri ENSTBEG00000017713 I 0.855
MITF Taeniopygia guttata ENSTGUG00000009847 I 0.855
mitfa Tetraodon nigroviridis ENSTNIG00000007360 I 0.855
mitfb Tetraodon nigroviridis ENSTNIG00000012564 I 0.855
mitfa Takifugu rubripes ENSTRUG00000001600 I 0.855
mitfb Takifugu rubripes ENSTRUG00000012080 I 0.855
ENSTSYG00000011324 Tarsius syrichta ENSTSYG00000011324 I 0.855
MITF Tursiops truncatus ENSTTRG00000007072 I 0.855
ENSXMAG00000002200 Xiphophorus maculatus ENSXMAG00000002200 I 0.855
ENSXMAG00000016472 Xiphophorus maculatus ENSXMAG00000016472 I 0.855
Aan_R007225 Calypte anna Aan_R007225 I 0.855
Afo_R011673 Aptenodytes forsteri Afo_R011673 I 0.855
Alligator_sinensis_CCG002397.1 Alligator sinensis Alligator_sinensis_CCG002397.1 I 0.855
Alligator_sinensis_CCG004214.1 Alligator sinensis Alligator_sinensis_CCG004214.1 I 0.855
Brh_R009446 Buceros rhinoceros Brh_R009446 I 0.855
ENSBTAP00000053693-D1 Bos grunniens ENSBTAP00000053693-D1 I 0.855
ENSP00000391803 Macaca fascicularis ENSP00000391803 I 0.855
Gfo_R014572 Geospiza fortis Gfo_R014572 I 0.855
Myotis_brandtii_Mitf_10022588 Myotis brandtii Myotis_brandtii_Mitf_10022588 I 0.855
Pvit_00330 Pogona vitticeps Pvit_00330 I 0.855
Pvit_01233 Pogona vitticeps Pvit_01233 I 0.855
Tal_R001329 Tyto alba Tal_R001329 I 0.855
mitf Xenopus tropicalis XB-GENE-484962 I 0.855
mitf.L Xenopus laevis XB-GENE-6252679 I 0.855
mitf.S Xenopus laevis XB-GENE-6464338 I 0.855
tfeb Oryzias latipes ENSORLG00000015866 I 0.846
ENSPMAG00000001002 Petromyzon marinus ENSPMAG00000001002 I 0.843
TFE3 Monodelphis domestica ENSMODG00000009925 I 0.842