CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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EPAS1
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000116016
T034267_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
EPAS1
M08719_2.00
Homo sapiens
VDACGTGMN
NKCACGTHB
Misc
Kulakovskiy et al.(2013)
EPAS1_HUMAN.H11MO.0.B
(Direct)
(Direct)
EPAS1
M09455_2.00
Homo sapiens
KCACGTMBNH
DNVKACGTGM
Misc
Heinz et al.(2010)
785_O-HIF2a_GSE34871
(Direct)
(Direct)
EPAS1
M09826_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF2A_01
(Direct)
(Direct)
EPAS1
M09827_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF2A_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000263734
bHLH
15
68
RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHK
ENSP00000406137
bHLH
15
68
RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHK
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
5 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Epas1
Dipodomys ordii
ENSDORG00000003635
I
0.914
Tal_R006997
Tyto alba
Tal_R006997
I
0.861
ENSTNIG00000019821
Tetraodon nigroviridis
ENSTNIG00000019821
I
0.858
epas1.L
Xenopus laevis
XB-GENE-981617
I
0.843