CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
Home
Tools
View cart
Bulk downloads
Database stats
Contact us
Help
Update Log
FAQ
Links
How to cite
HEY2
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000135547
T034289_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HEY2
M02790_2.00
Homo sapiens
GRCACGTGNV
BNCACGTGYC
SELEX
Jolma et al.(2013)
HEY2_1
(Direct)
(Direct)
HEY2
M02791_2.00
Homo sapiens
GVCACGTGYN
NRCACGTGBC
SELEX
Jolma et al.(2013)
HEY2_2
(Direct)
(Direct)
HEY2
M04131_2.00
Homo sapiens
NVCRCGYGVN
NBCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX
(Direct)
(Direct)
HEY2
M04132_2.00
Homo sapiens
NVCRCGYRVN
NBYRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
HEY2
M04133_2.00
Homo sapiens
NVCACGTGVN
NBCACGTGBN
SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX
(Direct)
(Direct)
HEY2
M04134_2.00
Homo sapiens
NVCRCGYGSN
NSCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hey2
M01722_2.00
Mus musculus
RCACGTGNN
NNCACGTGY
PBM
Weirauch et al.(2014)
pTH5102
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000357348
bHLH
49
104
RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQ
ENSP00000357349
bHLH
3
58
RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQ
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
164 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSLOCG00000017268
Lepisosteus oculatus
ENSLOCG00000017268
I
0.914
Afo_R005555
Aptenodytes forsteri
Afo_R005555
I
0.914
HEY2
Loxodonta africana
ENSLAFG00000014208
I
0.914
HEY2
Meleagris gallopavo
ENSMGAG00000013281
I
0.914
HEY2
Myotis lucifugus
ENSMLUG00000002617
I
0.914
Aan_R009606
Calypte anna
Aan_R009606
I
0.914
HEY2
Macaca mulatta
ENSMMUG00000009491
I
0.914
Alligator_sinensis_CCG009102.1
Alligator sinensis
Alligator_sinensis_CCG009102.1
I
0.914
Brh_R011837
Buceros rhinoceros
Brh_R011837
I
0.914
HEY2
Felis catus
ENSFCAG00000026914
I
0.914
Gfo_R016187
Geospiza fortis
Gfo_R016187
I
0.914
ENSFALG00000011461
Ficedula albicollis
ENSFALG00000011461
I
0.914
ENSP00000357348
Macaca fascicularis
ENSP00000357348
I
0.914
Cmyd_10006677
Chelonia mydas
Cmyd_10006677
I
0.914
ENSP00000357348-D1
Bos grunniens
ENSP00000357348-D1
I
0.914
HEY2
Monodelphis domestica
ENSMODG00000017701
I
0.914
ENSMPUG00000014531
Mustela putorius furo
ENSMPUG00000014531
I
0.914
HEY2
Pan troglodytes
ENSPTRG00000018574
I
0.914
ENSPSIG00000012495
Pelodiscus sinensis
ENSPSIG00000012495
I
0.914
ENSPPYG00000016987
Pongo abelii
ENSPPYG00000016987
I
0.914
HEY2
Sus scrofa
ENSSSCG00000004223
I
0.914
Hey2
Rattus norvegicus
ENSRNOG00000013364
I
0.914
ENSSHAG00000016487
Sarcophilus harrisii
ENSSHAG00000016487
I
0.914
HEY2
Sorex araneus
ENSSARG00000011755
I
0.914
ENSSTOG00000022371
Ictidomys tridecemlineatus
ENSSTOG00000022371
I
0.914
HEY2
Tupaia belangeri
ENSTBEG00000008836
I
0.914
ENSOANG00000022119
Ornithorhynchus anatinus
ENSOANG00000022119
I
0.914
ENSNLEG00000013972
Nomascus leucogenys
ENSNLEG00000013972
I
0.914
Hey2
Mus musculus
ENSMUSG00000019789
D
0.914
ENSOARG00000007915
Ovis aries
ENSOARG00000007915
I
0.914
HEY2
Vicugna pacos
ENSVPAG00000010498
I
0.914
HEY2
Taeniopygia guttata
ENSTGUG00000011792
I
0.914
HEY2
Otolemur garnettii
ENSOGAG00000027812
I
0.914
HEY2
Echinops telfairi
ENSETEG00000007340
I
0.914
ENSLACG00000006098
Latimeria chalumnae
ENSLACG00000006098
I
0.914
HEY2
Cavia porcellus
ENSCPOG00000021417
I
0.914
ENSCAFG00000032212
Canis familiaris
ENSCAFG00000032212
I
0.914
Pvit_01735
Pogona vitticeps
Pvit_01735
I
0.914
ENSCSAG00000016312
Chlorocebus sabaeus
ENSCSAG00000016312
I
0.914
hey2
Danio rerio
ENSDARG00000013441
I
0.914
HEY2
Bos taurus
ENSBTAG00000000919
I
0.914
ENSAPLG00000003195
Anas platyrhynchos
ENSAPLG00000003195
I
0.914
HEY2
Anolis carolinensis
ENSACAG00000001813
I
0.914
ENSAMEG00000009592
Ailuropoda melanoleuca
ENSAMEG00000009592
I
0.914
hey2
Xenopus tropicalis
XB-GENE-485923
I
0.914
ENSAMXG00000018013
Astyanax mexicanus
ENSAMXG00000018013
I
0.914
Ogr15033
Ophisaurus gracilis
Ogr15033
I
0.914
HEY2
Callithrix jacchus
ENSCJAG00000003761
I
0.914
HEY2
Dasypus novemcinctus
ENSDNOG00000044967
I
0.914
ENSDORG00000009001
Dipodomys ordii
ENSDORG00000009001
I
0.914
HEY2
Equus caballus
ENSECAG00000014094
I
0.914
Myotis_brandtii_hey2_10035635
Myotis brandtii
Myotis_brandtii_hey2_10035635
I
0.914
HEY2
Erinaceus europaeus
ENSEEUG00000014040
I
0.914
Ocbimv22039104m.g
Octopus bimaculoides
Ocbimv22039104m.g
I
0.890
ISCW011251
Ixodes scapularis
ISCW011251
I
0.890
CGI_10018323
Crassostrea gigas
CGI_10018323
I
0.890
ENSLACG00000012215
Latimeria chalumnae
ENSLACG00000012215
I
0.890
estExt_GenewiseH_1.C_4620016
Branchiostoma floridae
estExt_GenewiseH_1.C_4620016
I
0.887
ENSONIG00000018772
Oreochromis niloticus
ENSONIG00000018772
I
0.886
ENSOCUG00000029649
Oryctolagus cuniculus
ENSOCUG00000029649
I
0.871
HEYL
Bos taurus
ENSBTAG00000008688
I
0.870
HEYL
Gorilla gorilla
ENSGGOG00000008268
I
0.870
HEYL
Oryctolagus cuniculus
ENSOCUG00000000560
I
0.870
PABPC4
Canis familiaris
ENSCAFG00000003081
I
0.870
ENSOARG00000020088
Ovis aries
ENSOARG00000020088
I
0.870
HEYL
Equus caballus
ENSECAG00000007220
I
0.870
ENSPANG00000006227
Papio anubis
ENSPANG00000006227
I
0.870
ENSAMEG00000011612
Ailuropoda melanoleuca
ENSAMEG00000011612
I
0.870
HEYL
Pan troglodytes
ENSPTRG00000000574
I
0.870
Heyl
Rattus norvegicus
ENSRNOG00000015318
I
0.870
ENSSSCG00000024651
Sus scrofa
ENSSSCG00000024651
I
0.870
ENSPPYG00000001505
Pongo abelii
ENSPPYG00000001505
I
0.870
HEYL
Tursiops truncatus
ENSTTRG00000014353
I
0.870
ENSAPLG00000007121
Anas platyrhynchos
ENSAPLG00000007121
I
0.870
HEYL
Otolemur garnettii
ENSOGAG00000030877
I
0.870
HEYL
Ornithorhynchus anatinus
ENSOANG00000010000
I
0.870
HEYL
Loxodonta africana
ENSLAFG00000027563
I
0.870
ENSMEUG00000007444
Macropus eugenii
ENSMEUG00000007444
I
0.870
L798_14068
Zootermopsis nevadensis
L798_14068
I
0.870
ENSCSAG00000001134
Chlorocebus sabaeus
ENSCSAG00000001134
I
0.870
ENSGALG00000021593
Gallus gallus
ENSGALG00000021593
I
0.870
Alligator_sinensis_CCG011017.1
Alligator sinensis
Alligator_sinensis_CCG011017.1
I
0.870
Cmyd_10005434
Chelonia mydas
Cmyd_10005434
I
0.870
HEYL
Dasypus novemcinctus
ENSDNOG00000010392
I
0.870
ENSSHAG00000018213
Sarcophilus harrisii
ENSSHAG00000018213
I
0.870
ENSP00000361943
Macaca fascicularis
ENSP00000361943
I
0.870
ENSP00000361943-D1
Bos grunniens
ENSP00000361943-D1
I
0.870
HEYL
Homo sapiens
ENSG00000163909
I
0.870
Heyl
Mus musculus
ENSMUSG00000032744
I
0.870
PHUM454530
Pediculus humanus
PHUM454530
I
0.870
ENSMPUG00000014412
Mustela putorius furo
ENSMPUG00000014412
I
0.870
ENSFALG00000000542
Ficedula albicollis
ENSFALG00000000542
I
0.870
HEYL
Macaca mulatta
ENSMMUG00000018861
I
0.870
ENSCPOG00000000704
Cavia porcellus
ENSCPOG00000000704
I
0.870
Myotis_brandtii_HEY1_10021379
Myotis brandtii
Myotis_brandtii_HEY1_10021379
I
0.860
HEY1
Takifugu rubripes
ENSTRUG00000013573
I
0.860
hey1
Xenopus tropicalis
XB-GENE-486694
I
0.860
hey1.S
Xenopus laevis
XB-GENE-865637
I
0.860
Brh_R005579
Buceros rhinoceros
Brh_R005579
I
0.860
Ogr14041
Ophisaurus gracilis
Ogr14041
I
0.860
HEY1
Sus scrofa
ENSSSCG00000006159
I
0.860
Gfo_R007552
Geospiza fortis
Gfo_R007552
I
0.860
ENSSTOG00000023191
Ictidomys tridecemlineatus
ENSSTOG00000023191
I
0.860
Pvit_00065
Pogona vitticeps
Pvit_00065
I
0.860
Afo_R005157
Aptenodytes forsteri
Afo_R005157
I
0.860
SPU_009465
Strongylocentrotus purpuratus
SPU_009465
I
0.860
HEY1
Tetraodon nigroviridis
ENSTNIG00000018401
I
0.860
Sakowv30023592m.g
Saccoglossus kowalevskii
Sakowv30023592m.g
I
0.860
ENSOARG00000008063
Ovis aries
ENSOARG00000008063
I
0.860
ENSGMOG00000013488
Gadus morhua
ENSGMOG00000013488
I
0.860
HEY1
Gorilla gorilla
ENSGGOG00000009960
I
0.860
HEY1
Gasterosteus aculeatus
ENSGACG00000008712
I
0.860
hey1
Gasterosteus aculeatus
ENSGACG00000003436
I
0.860
ENSGMOG00000017811
Gadus morhua
ENSGMOG00000017811
I
0.860
ENSLACG00000015540
Latimeria chalumnae
ENSLACG00000015540
I
0.860
ENSMPUG00000001859
Mustela putorius furo
ENSMPUG00000001859
I
0.860
ENSSHAG00000017958
Sarcophilus harrisii
ENSSHAG00000017958
I
0.860
HEY1
Loxodonta africana
ENSLAFG00000011488
I
0.860
HEY1
Homo sapiens
ENSG00000164683
D
0.860
HEY1
Felis catus
ENSFCAG00000025542
I
0.860
HEY1
Cavia porcellus
ENSCPOG00000008527
I
0.860
HEY1
Canis familiaris
ENSCAFG00000008391
I
0.860
HEY1
Bos taurus
ENSBTAG00000015717
I
0.860
ENSCSAG00000013410
Chlorocebus sabaeus
ENSCSAG00000013410
I
0.860
hey1
Danio rerio
ENSDARG00000070538
I
0.860
ENSFALG00000008605
Ficedula albicollis
ENSFALG00000008605
I
0.860
HEY1
Equus caballus
ENSECAG00000017010
I
0.860
HEY1
Dasypus novemcinctus
ENSDNOG00000031981
I
0.860
Hey1
Mus musculus
ENSMUSG00000040289
I
0.860
HEY1
Monodelphis domestica
ENSMODG00000006648
I
0.860
ENSONIG00000003087
Oreochromis niloticus
ENSONIG00000003087
I
0.860
HEY1
Otolemur garnettii
ENSOGAG00000007210
I
0.860
ENSPPYG00000018693
Pongo abelii
ENSPPYG00000018693
I
0.860
ENSPFOG00000001913
Poecilia formosa
ENSPFOG00000001913
I
0.860
ENSPANG00000018687
Papio anubis
ENSPANG00000018687
I
0.860
HEY1
Oryzias latipes
ENSORLG00000008268
I
0.860
Hey1
Rattus norvegicus
ENSRNOG00000011593
I
0.860
ENSPSIG00000003791
Pelodiscus sinensis
ENSPSIG00000003791
I
0.860
ENSNLEG00000002239
Nomascus leucogenys
ENSNLEG00000002239
I
0.860
hey1
Tetraodon nigroviridis
ENSTNIG00000017785
I
0.857
Aqu1.218726
Amphimedon queenslandica
Aqu1.218726
I
0.857
hey1
Takifugu rubripes
ENSTRUG00000014561
I
0.857
HEYL
Myotis lucifugus
ENSMLUG00000029490
I
0.845
CapteG182542
Capitella teleta
CapteG182542
I
0.840
heyl
Oryzias latipes
ENSORLG00000013651
I
0.840
CapteG228069
Capitella teleta
CapteG228069
I
0.840
heyl
Danio rerio
ENSDARG00000055798
I
0.840
LDEC001043
Leptinotarsa decemlineata
LDEC001043
I
0.840
ENSPFOG00000015536
Poecilia formosa
ENSPFOG00000015536
I
0.840
ENSAMXG00000011237
Astyanax mexicanus
ENSAMXG00000011237
I
0.840
heyl
Takifugu rubripes
ENSTRUG00000003399
I
0.840
ENSLOCG00000001853
Lepisosteus oculatus
ENSLOCG00000001853
I
0.840
ENSXMAG00000014241
Xiphophorus maculatus
ENSXMAG00000014241
I
0.840
YQE_09192
Dendroctonus ponderosae
YQE_09192
I
0.840
tetur01g03020
Tetranychus urticae
tetur01g03020
I
0.840
TC001593
Tribolium castaneum
TC001593
I
0.840
ENSXMAG00000006950
Xiphophorus maculatus
ENSXMAG00000006950
I
0.840
ENSGMOG00000011084
Gadus morhua
ENSGMOG00000011084
I
0.840
HEYL
Felis catus
ENSFCAG00000010963
I
0.840
LotgiG171867
Lottia gigantea
LotgiG171867
I
0.840
heyl
Gasterosteus aculeatus
ENSGACG00000007492
I
0.840
ENSONIG00000004726
Oreochromis niloticus
ENSONIG00000004726
I
0.840
heyl
Tetraodon nigroviridis
ENSTNIG00000009228
I
0.840